Simultaneous and instrument-free detection of quinine and crystal violet based on a dual-emissive Eu-functionalized metal-organic framework.

Simultaneous detection and quantification of multi-targets is a challenge using one single sensor in the complicated environment of real samples. Herein, we developed a dual-emissive sensor (EuUCHNA) that selectively and rapidly responds to crystal violet (CV) and quinine (QN), two commonly used anti-infective drugs for fungi, bacteria, and parasites, through distinct responsive modes. CV can effectively quench the blue and red fluorescent emission bands of EuUCHNA.

Region-guided focal adversarial learning for CT-to-MRI translation: A proof-of-concept and validation study in hepatocellular carcinoma.

Background: Generative adversarial networks (GANs) have recently demonstrated significant potential for producing virtual images with the same characteristics as real-life landscapes, thereby enhancing various medical tasks.

Purpose: To design a region-guided focal GAN (Focal-GAN) for translating images between CT and MRI and test its clinical applicability in patients with hepatocellular carcinoma (HCC).

Methods: Between January 2012 and October 2021, two cohorts of patients with HCC who underwent contrast-enhanced CT (Center 1, n = 685) and MRI (Center 1, n = 516; Center 2, n = 318) were retrospectively enrolled.

Three new diterpenes from the roots of Salvia miltiorrhiza and their cytotoxicity.

Two undescribed oxazole-containing diterpenoids (1-2) and a new diterpenoid (3) were isolated from the roots of Salvia miltiorrhiza. Their structures were elucidated by extensive HRESIMS and NMR spectroscopic analysis, and the absolute configurations of 1 and 3 were confirmed by comparison of the calculated and experimental electronic circular dichroism (ECD) spectra. Compound 1 represents the first example of an abietane diterpenoid with a benzo[d]oxazole unit fused in the ring B of the abietane skeleton.

A foundation model with weak experiential guidance in detecting muscle invasive bladder cancer on MRI.

Preoperative detection of muscle-invasive bladder cancer (MIBC) remains a great challenge in practice. We aimed to develop and validate a deep Vesical Imaging Network (ViNet) model for the detection of MIBC using high-resolution Tweighted MR imaging (hrTWI) in a multicenter cohort. ViNet was designed using a modified 3D ResNet, in which, the encoder layers were pretrained using a self-supervised foundation model on over 40,000 cross-modal imaging datasets for transfer learning, and the classification modules were weakly supervised by an experiential knowledge-domain mask indicated by a nnUNet segmentation model.

Artemisinins ameliorate polycystic ovarian syndrome by mediating LONP1-CYP11A1 interaction.

Polycystic ovary syndrome (PCOS), a prevalent reproductive disorder in women of reproductive age, features androgen excess, ovulatory dysfunction, and polycystic ovaries. Despite its high prevalence, specific pharmacologic intervention for PCOS is challenging. In this study, we identified artemisinins as anti-PCOS agents.

A facile and intelligent detection method for diclazuril based on a stable dual emissive Eu-dopped metal-organic framework.

Diclazuril (DIC) is a broad-spectrum anti-coccidiosis drug of the triazine class, widely used in poultry farming. The overuse of DIC may lead to its accumulation in animal bodies, which may enter the food chain and threaten human health. In this work, we fabricated a stable Eu-doped UiO-66 fluorescence sensor (EuUHIPA-30) for the sensitive detection of DIC.

NR2F6 is essential for brown adipocyte differentiation and systemic metabolic homeostasis.

Objective: Brown adipose tissue (BAT) development and function are essential for maintaining energy balance. However, the key factors that specifically regulate brown adipogenesis require further identification. Here, we demonstrated that the nuclear receptor subfamily 2 group F member 6 (NR2F6) played a pivotal role in brown adipogenesis and energy homeostasis.

Multifunctional Eu-MOF for simultaneous quantification of malachite green and leuco-malachite green and efficient adsorption of malachite green.

Multi-target detection combined with in-situ removal of contaminants is a challenging issue difficult to overcome. Herein, a dual-emissive Eu-metal organic framework (Eu-MOF) was constructed by pre-functionalization with a blue-emissive ligand and post-functionalization with red-emissive Eu ions using a UiO-66 precursor. The fluorescence of the synthesized Eu-MOF is highly selective and sensitive toward malachite green (MG) and its metabolite leuco-malachite green (LMG), which are environmentally persistent and highly toxic to humans.

A recyclable Eu-functionalized dual-emissive metal-organic framework for portable, rapid detection and efficient removal of malachite green.

A europium-functionalized, dual-emissive, metal-organic framework-based fluorescence sensor (EuUCNDA) was constructed post-synthetic modification of an UiO-66-type precursor through coordination interactions. EuUCNDA exhibited extremely high selectivity and sensitivity for malachite green (MG) with a low detection limit of 13.01 nM, a wide linear concentration range (0.

A highly water-stable dual-emission fluorescent probe based on Eu-loaded MOF for the simultaneous detection and quantification of Fe and Al in swine wastewater.

A novel dual-emissive Eu-loaded metal-organic framework (MOF) is designed and successfully fabricated by introducing 2-hydroxyterephthalic acid (HBDC-OH) and Eu ions into an UiO-66-type MOF material. The obtained MOF, here referred to as EuUCH, exhibits dual emission at 450 and 614 nm, and both emissions are quite stable in aqueous media in the pH range of 4-11. EuUCH is characterized by a high selectivity and sensitivity toward Fe and Al, which yield different responsive modes.

A dual-channel "on-off-on" fluorescent probe for the detection and discrimination of Fe and Hg in piggery feed and swine wastewater.

Blue-fluorescent blood-CDs were synthesized through a one-pot hydrothermal method using a mixture of chicken blood and trisodium citrate and then explored as a fluorescent probe for detecting Fe and Hg. The probe showed excellent selectivity and sensitivity towards Fe and Hg with a dramatic "on-off" fluorescence response. F recovered the fluorescence quenching by Fe, and Al recovered the fluorescence quenching by Hg, showing an "off-on" fluorescence response.

Study on Factors Associated with High Myopia CNV in Aqueous Humor and Serum.

Objective: The objective is to investigate the relationship and correlation between PEDF and TGF- in aqueous humor and serum and high myopia CNV lesions.

Methods: For each group of patients (namely, group A: patients with high myopia CNV (mCNV); group B: patients with high myopia without CNV; group C: patients with CNV caused by other eye diseases; and group D (control group): patients with simple cataract (without CNV and high myopia)), 20 patients were collected. A total of 40 patients have been collected since the beginning of the study in December 2020, including 7 patients in group A, 13 patients in group B, 10 patients in group C, and 10 patients in group D.

A luminescent Eu-functionalized MOF for sensitive and rapid detection of tetracycline antibiotics in swine wastewater and pig kidney.

Tetracyclines (TCs), a type of antibiotics, are widely used in human therapy and animal husbandry. Public concerns about tetracyclines residues have been raised due to their negative impact on the environment and food, causing bacterias drug resistance and human health concerns. In this work, a luminescent europium MOF (EuUCBA) is constructed via post-synthetic attachment of Eu into a UiO-66 type MOF.

Recyclable europium functionalized metal-organic fluorescent probe for detection of tryptophan in biological fluids and food products.

An europium functionalized metal-organic fluorescent probe, Eu@UiO-66-FDC was constructed by post-synthetic modification through coordination interactions. Eu@UiO-66-FDC displayed high selectivity and sensitivity toward Tryptophan (Trp) among all the 20 natural amino acids and other general compounds in food and biological samples, with a wide linear concentration range (0-1000 μM), low detection limit (0.29 μM), and a rapid response (<1 min).

Highly sensitive and rapid detection of thiabendazole residues in oranges based on a luminescent Tb-functionalized MOF.

Thiabendazole (TBZ), has been extensively employed as a pesticide and/or a fungicide in agriculture, while its residues would threaten to public health and safety. Simple, rapid and sensitive probes for detection of TBZ in real food samples is significantly desirable. In present work, a highly selective and sensitive luminescent sensor for monitoring TBZ in oranges has been constructed based on a Tb-functionalized Zr-MOF (Tb@1).

Predicting disease risks by matching quantiles estimation for censored data.

In time to event data analysis, it is often of interest to predict quantities such as t-year survival rate or the survival function over a continuum of time. A commonly used approach is to relate the survival time to the covariates by a semiparametric regression model and then use the fitted model for prediction, which usually results in direct estimation of the conditional hazard function or the conditional estimating equation. Its prediction accuracy, however, relies on the correct specification of the covariate-survival association which is often difficult in practice, especially when patient populations are heterogeneous or the underlying model is complex.