Pharmacokinetic/pharmacodynamic evaluation of gamithromycin against rabbit pasteurellosis.

Background: Gamithromycin is an effective therapy for bovine and swine respiratory diseases but not utilized for rabbits. Given its potent activity against respiratory pathogens, we sought to determine the pharmacokinetic profiles, antimicrobial activity and target pharmacokinetic/pharmacodynamic (PK/PD) exposures associated with therapeutic effect of gamithromycin against Pasteurella multocida in rabbits.

Results: Gamithromycin showed favorable PK properties in rabbits, including high subcutaneous bioavailability (86.