Publications by authors named "Yi-Dong Zhu"

Article Synopsis
  • * The structures of these compounds were determined using advanced spectroscopic methods, including NMR and mass spectrometry.
  • * The new compounds demonstrated significant inhibitory effects on HepG2 cancer cells, with IC values comparable to the positive control cisplatin, indicating potential for cancer treatment.
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Four previously undescribed diastereomeric lignan glycosides, namely cistadesertosides B-E (1-4) were isolated from the stems of cultural Cistanche deserticola in Tarim desert. The structures of these compounds were elucidated on the basis of extensive spectroscopic analyses, including IR, HR-ESI-MS, 1D and 2D NMR, circular dichroism (CD) data and chemical degradation. The in vitro anti-inflammatory activity of the isolates was also investigated.

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Article Synopsis
  • * Advanced techniques like IR, NMR, and ECD calculations were used to determine the structures of these compounds.
  • * The compounds were tested for their effects on cancer cell growth, revealing that some, particularly compounds 7 and 15, had strong inhibitory effects on A549 cells, while others showed varying levels of activity against H1299 and HepG2 cancer cells.
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Posttranslational modifications add tremendous complexity to proteomes; however, gaps remain in knowledge regarding the function and regulatory mechanism of newly discovered lysine acylation modifications. Here, we compared a panel of non-histone lysine acylation patterns in metastasis models and clinical samples, and focused on 2-hydroxyisobutyrylation (Khib) due to its significant upregulation in cancer metastases. By the integration of systemic Khib proteome profiling in 20 paired primary esophageal tumor and metastatic tumor tissues with CRISPR/Cas9 functional screening, we identified N-acetyltransferase 10 (NAT10) as a substrate for Khib modification.

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Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. Identification of the underlying mechanism of HCC progression and exploration of new therapeutic drugs are urgently needed. Here, a compound library consisting of 419 FDA-approved drugs was taken to screen potential anticancer drugs.

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