Publications by authors named "Yi-Ding Qi"
Article Synopsis
- Gegen Qinlian decoction (GGQLD) is a traditional Chinese medicine used in clinical settings to manage inflammatory symptoms related to metabolic diseases and protect kidney function, with a specific focus on its effects against hyperuricemia (HUA).
- A study involving 30 HUA patients explored the impact of GGQLD on uric acid levels and inflammatory markers before and after a 4-week treatment, alongside further experimentation using animal models and kidney cells.
- Results indicated that GGQLD decreased inflammation and apoptosis in renal cells by lowering NLRP3 inflammasome expression, enhancing uric acid excretion, and demonstrating a multi-target approach to HUA treatment.
Aims: We aimed to investigate whether LCZ696 protects against pathological cardiac hypertrophy by regulating the Sirt3/MnSOD pathway.
Methods: , we established a transverse aortic constriction animal model to establish pressure overload-induced heart failure. Subsequently, the mice were given LCZ696 by oral gavage for 4 weeks.