Publications by authors named "Yi-Dan Hao"
High-Energy Phosphates and Ischemic Heart Disease: From Bench to Bedside.
Front Cardiovasc Med
July 2021
Article Synopsis
- The review aims to connect clinical and basic research by outlining the cellular and molecular mechanisms of cardioprotection and assessing evidence about high-energy phosphates (HEPs) in ischemic heart disease (IHD).
- Exogenous creatine phosphate (CrP) is highlighted as a potential key metabolic regulator that offers cardioprotection through various complex mechanisms, primarily by replenishing cellular energy.
- While CrP has not been shown to enhance long-term survival rates, it has demonstrated beneficial effects on several important secondary outcomes, indicating a need for well-designed multicenter randomized controlled trials (RCTs) to further investigate its impact on long-term survival.
Objective: To evaluate the effects and mechanisms of glucose-insulin-potassium (GIK) on post-procedural myocardial injury (PMI) after percutaneous coronary intervention (PCI).
Methods: A total of 200 non-diabetic patients with documented coronary heart disease (CHD) were divided into the Group GIK and Group G, with 100 patients in each group. Patients in Group G were given intravenous infusion of glucose solution 2 hours before PCI.
Article Synopsis
- Genetic factors play a significant role in the development of coronary artery disease (CAD) and myocardial infarction (MI), but identifying specific genes remains challenging due to varying patient characteristics.
- The study details two cases of a father and son who both suffered acute myocardial infarctions (AMI) with similar symptoms and coronary artery blockages, particularly in the left anterior descending (LAD) artery.
- The findings suggest that similar clinical presentations in patients should enhance genetic research efforts to better understand CAD and MI.