Sinomenine Inhibits Migration and Invasion of Human Lung Cancer Cell through Downregulating Expression of miR-21 and MMPs.

Sinomenine is an alkaloid derived from . Recent studies have found that sinomenine can inhibit various cancers by inhibiting the proliferation, migration and invasion of tumors and inducing apoptosis. This study aims to investigate the effect and mechanism of sinomenine on inhibiting the migration and invasion of human lung adenocarcinoma cells in vitro.

The potential effect of a vibrotactile glove rehabilitation system on motor recovery in chronic post-stroke hemiparesis.

Background: Poor fine motor skills are common among chronic stroke patients. Conventional rehabilitation programs only emphasize intensive and repeated exercises that do not motivate patients to continue rehabilitation. Using a vibrotactile glove rehabilitation system with a human-computer interaction interface can therefore resolve this issue.

Oxidant-dependent chemoselectivity in the gold-catalyzed oxidative cyclizations of 3,4,6,6-tetrasubstituted 3,5-dien-1-ynes.

A distinct chemoselectivity in the gold-catalyzed oxidative cyclization of 3,5-dien-1-ynes was observed when 3,5-dichloropyridine N-oxide replaced 8-methylquinoline N-oxide as the oxidant; the resulting cyclopentadienyl aldehydes were obtained in good yields. The altered chemoselectivity is attributed to a prior enyne cyclization in the presence of 3,5-dichloropyridine N-oxides. The use of N-iminopyridium ylide enables a similar iminocyclization reaction to give cyclopentadienyl imines efficiently.

Shape modification of the Boston brace using a finite-element method with topology optimization.

Study Design: Using a finite-element (FE) method to reshape the Boston brace, and evaluating the correction effect of the modified Boston brace in terms of Cobb angle.

Objective: This study aimed to reduce the weight of the Boston brace using a FE method with topology optimization.

Summary Of Background Data: The Boston brace is widely used to correct an abnormal spinal curve in adolescent idiopathic scoliosis.