PIAS1 S510G variant acts as a genetic modifier of spinocerebellar ataxia type 3 by selectively impairing mutant ataxin-3 proteostasis.

Dysregulated protein homeostasis, characterized by abnormal protein accumulation and aggregation, is a key contributor to the progression of neurodegenerative disorders such as Huntington's disease and spinocerebellar ataxia type 3 (SCA3). Previous studies have identified PIAS1 gene variants in patients with late-onset SCA3 and Huntington's disease. This study aims to elucidate the role of PIAS1 and its S510G variant in modulating the pathogenic mechanisms of SCA3.

Activation of IGF-1 pathway and suppression of atrophy related genes are involved in Epimedium extract (icariin) promoted C2C12 myotube hypertrophy.

The regenerative effect of Epimedium and its major bioactive flavonoid icariin (ICA) have been documented in traditional medicine, but their effect on sarcopenia has not been evaluated. The aim of this study was to investigate the effects of Epimedium extract (EE) on skeletal muscle as represented by differentiated C2C12 cells. Here we demonstrated that EE and ICA stimulated C2C12 myotube hypertrophy by activating several, including IGF-1 signal pathways.

Thermal Cycling Effect on Transformation Temperatures of Different Transformation Sequences in TiNi-Based Shape Memory Alloys.

In TiNi-based shape memory alloys (SMAs), the effects of thermal cycling on the transformation peak temperatures of B2 ↔ B19', B2 ↔ R, B2 ↔ B19, B2 ↔ R ↔ B19', and B2 ↔ B19 ↔ B19' one-stage and two-stage transformations have been investigated and compared. Experimental results of the differential scanning calorimeter and hardness tests indicate that the alloy's intrinsic hardness and the shear strain, , associated with martensitic transformation, are two important factors, due to their relation to the ease of introducing dislocations during cycling. The temperature decrease by cycling for one-stage transformation was in the order of B2 ↔ B19' > B2 ↔ B19 > B2 ↔ R according to the orders of magnitude of their values.

[Improvement Project Introducing the Hospital Environment to New Patients in Pediatric Wards].

Background & Problems: The pediatric ward in our hospital has an average occupancy rate of ten patients per day. An investigation found that nurses had a low (51.9%) rate of completing the required introduction to the hospital environment for pediatric ward patients.

Ultrasound-Induced Reactive Oxygen Species Mediated Therapy and Imaging Using a Fenton Reaction Activable Polymersome.

Ultrasound techniques have been extensively employed for diagnostic purposes. Because of its features of low cost, easy access, and noninvasive real-time imaging, toward clinical practice it is highly anticipated to simply use diagnostic ultrasound to concurrently perform imaging and therapy. We report a H2O2-filled polymersome to display echogenic reflectivity and reactive oxygen species-mediated cancer therapy simply triggered by the microultrasound diagnostic system accompanied by MR imaging.

Microfluidic one-step synthesis of Fe₃O₄-chitosan composite particles and their applications.

This paper demonstrates a simple and easy approach for the one-step synthesis of Fe₃O₄-chitosan composite particles with tadpole-like shape. The length and diameter of the particles were adjustable from 638.3 μm to ca.

Synthesis and characterization of oil-chitosan composite spheres.

Oil-chitosan composite spheres were synthesized by encapsulation of sunflower seed oil in chitosan droplets, dropping into NaOH solution and in situ solidification. Hydrophilic materials (i.e.

Molecular epidemiology of group A streptococcus causing scarlet fever in northern Taiwan, 2001-2002.

In this study, 830 Streptococcus pyogenes isolates collected between 2001 and 2002 from patients with scarlet fever in northern Taiwan were analyzed by M protein gene (emm) sequence typing, pulsed-field gel electrophoresis (PFGE), and antimicrobial susceptibility testing. A total of 21 emm types and 56 PFGE patterns were identified. The most frequent emm types were emm1 (29.

Surveillance of invasive Streptococcus pneumoniae in Taiwan, 2002-2003.

A total of 522 Streptococcus pneumoniae invasive isolates from diverse sources were collected from January 2002 to December 2003 in Taiwan in order to understand the serotype distribution of invasive isolates in Taiwan. The most frequently isolated serotypes of S. pneumoniae were types 14 (18.