Two MYB-related transcription factors play opposite roles in sugar signaling in Arabidopsis.

Sugar regulation of gene expression has profound effects at all stages of the plant life cycle. Although regulation at the transcriptional level is one of the most prominent mechanisms by which gene expression is regulated, only a few transcription factors have been identified and demonstrated to be involved in the regulation of sugar-regulated gene expression. OsMYBS1, an R1/2-type MYB transcription factor, has been demonstrated to be involved in sugar- and hormone-regulated α-amylase gene expression in rice.

Inhibition of Periodontitis Induction Using a Stimuli-Responsive Hydrogel Carrying Naringin.

Background: Developing a drug carrier with favorable handling characteristics that can respond to environmental changes after inflammation, such as pH changes, may be beneficial for treating periodontitis. This study aims to investigate the preclinical feasibility of using naringin, a naturally derived polymethoxylated flavonoid compound with anti-inflammatory properties, to inhibit periodontitis induction via a thermogelling and pH-responsive injectable hydrogel.

Methods: The hydrogel was made of amphipathic carboxymethyl-hexanoyl chitosan (CHC), β-glycerol phosphate (β-GP), and glycerol.

pH-Responsive Hydrogel With an Anti-Glycation Agent for Modulating Experimental Periodontitis.

Background: Stimulus-responsive devices have emerged as a novel approach for local drug delivery. This study investigates the feasibility of a novel chitosan-based, pH-responsive hydrogel loaded with N-phenacylthiazolium bromide (PTB), which cleaves the crosslinks of advanced glycation end products on the extracellular matrix.

Methods: A chitosan-based hydrogel loaded with PTB was fabricated, and the in vitro release profile was evaluated within pH 5.

Surgical Site Assessment for Soft Tissue Management in Ridge Augmentation Procedures.

The success of bone augmentation is usually dependent on primary wound closure. This review provides a literature-based system to assess the predictability of achieving primary wound closure. Seven pertinent factors that determine the risk for wound exposure were identified: (1) the width of keratinized mucosa, (2) flap thickness, (3) flap tension, (4) vestibular depth, (5) type and (6) size of the bony defect, and (7) materials used.