A Novel Phenotype of the Factor 5 Gene Mutation (Homozygote Met1736Val and Heterozygote Asp68His) Is Associated With Moderate Factor V Deficiency.

Background: Factor V (FV) deficiency is a rare disease, with a low incidence rate in Asia. Therefore, the mutation in the Taiwanese population is poorly understood.

Methods: A Chinese family with FV deficiency was included, and the patient and his family members underwent mutation analysis.

Tailoring C-6-Substituted Coumarin Scaffolds for Novel Photophysical Properties and Stimuli-Responsive Chromism.

A judicious strategy was utilized to envision the substantial regio-positional effects of substituents on the photophysical properties of the 2-chromen-2-one-3-benzothiazole scaffold-based push-pull framework, named . Among them, reveals prominent excited-state intramolecular charge transfer with a large change of dipole moment (Δμ ∼ 18.23 D), hence displaying remarkable emission solvatochromism from the green (536 nm in cyclohexane) to far-red region (714 nm in dimethyl sulfoxide) and a high-temperature sensitivity (-0.