Current research and clinical trends in rosacea pathogenesis.

Background: Rosacea is a common and complex chronic inflammatory skin disorder, the pathophysiology and etiology of which remain unclear. Recently, significant new insights into rosacea pathogenesis have enriched and reshaped our understanding of the disorder. A systematic analysis based on current studies will facilitate further research on rosacea pathogenesis.

Automatic digital optical heterodyne phase locking loop in the milliradian domain for spaceborne laser interferometry.

We developed a digital optical phase locking loop (OPLL) with three advantages, including high precision of phase locking, high control bandwidth up to 2.8 MHz, and automatic laser locking strategy. Spaceborne laser interferometers will be used to measure tiny displacements caused by gravitational waves in millions of kilometers range.

Epidemiology and determinants of Clonorchis sinensis infection: A community-based study in southeastern China.

Clonorchiasis is caused by the ingestion of raw freshwater fish and causes high burden in East Asia. The epidemiological profiles and determinants of C. sinensis infection, knowledge, practice and attitude related to clonorchiasis were demonstrated in Hengxian county, Guangxi, China.

A systematic summary of survival and death signalling during the life of hair follicle stem cells.

Hair follicle stem cells (HFSCs) are among the most widely available resources and most frequently approved model systems used for studying adult stem cells. HFSCs are particularly useful because of their self-renewal and differentiation properties. Additionally, the cyclic growth of hair follicles is driven by HFSCs.

Programmed cell death in stem cell-based therapy: Mechanisms and clinical applications.

Stem cell-based therapy raises hopes for a better approach to promoting tissue repair and functional recovery. However, transplanted stem cells show a high death percentage, creating challenges to successful transplantation and prognosis. Thus, it is necessary to investigate the mechanisms underlying stem cell death, such as apoptotic cascade activation, excessive autophagy, inflammatory response, reactive oxygen species, excitotoxicity, and ischemia/hypoxia.

Severe hepatobiliary morbidity is associated with Clonorchis sinensis infection: The evidence from a cross-sectional community study.

Clonorchis sinensis infection is highly prevalent in Asia. Diverse hepatobiliary morbidity has been documented for C. sinensis infection.

High prevalence of Clonorchis sinensis infection in Guangxi, Southern China.

Background: Soil-transmitted helminths (STHs), such as hookworm, roundworm and whipworm, and food-borne trematodiases, including Clonorchis sinensis, remain a public health problem worldwide, especially in tropical and subtropical regions.

Objective: We aimed to determine the current prevalence of these parasites in Guangxi, China, which is located in a subtropical region.

Methods: A cross-sectional study and a 4-year longitudinal surveillance study were carried out.

[Epidemic situation and control strategy of malaria in Guangxi Zhuang Autonomous Region from 2011 to 2018].

Objective: To analyze the epidemic situation of malaria and explore the targeted control strategy in Guangxi from 2011 to 2018.

Methods: The malaria surveillance data were collected in Guangxi Zhuang Autonomous Region from 2011 to 2018, and a descriptive method was employed to analyze the epidemiological features of the malaria cases.

Results: A total of 2 944 malaria cases were reported in Guangxi Zhuang Autonomous Region from 2011 to 2018, including a case with local infection (0.

[Investigation on infections in marketed cats in Nanning City].

Objective: To understand infections in cats in Nanning City, so as to provide evidence for the control of the reservoir host of .

Methods: The cat livers were purchased from cat slaughterhouses in Nanning City. The cat gallbladder and liver were dissected, and liver flukes were collected and counted.

Cell-free miR-17-5p as a diagnostic biomarker for gastric cancer inhibits dendritic cell maturation.

Purpose: Gastric cancer (GC) patients display aberrant miRNA expression and defective dendritic cell function. However, the role of cancer cell-derived oncomiR in GC detection and dendritic cell (DC) maturation remains largely elusive.

Methods: Candidate miRNAs were selected by deep sequencing (8 GC plasma samples vs 8 control plasma samples; 8 GC tissues vs 8 adjacent normal gastric tissues) and confirmed by PCR with 164 plasma samples and 72 formalin-fixed paraffin-embedded GC tissue samples.

Performance evaluation of existing immunoassays for Clonorchis sinensis infection in China.

Background: Clonorchiasis ranks among the most important food-borne parasitic diseases in China. However, due to low compliance to traditional fecal examination techniques in the general population and medical personnel, immunodiagnosis is expected. This study evaluated, in parallel, the performance of four immunodiagnostic kits detecting clonorchiasis in China.

TLR2 signal influences the iNOS/NO responses and worm development in C57BL/6J mice infected with Clonorchis sinensis.

Background: Although the responses of inducible nitric oxide synthase (iNOS) and associated cytokine after Clonorchis sinensis infection have been studied recently, their mechanisms remain incompletely understood. In this study, we investigated the effects of toll-like receptor 2 (TLR2) signals on iNOS/nitric oxide (NO) responses after C. sinensis infection.

[Analysis of imported malaria epidemic situation and implication for prevention and control strategy in Guangxi Zhuang Autonomous Region in 2014].

Objective: To analyze the epidemic characteristics of the imported malaria cases in Guangxi Zhuang Autonomous Region in 2014, so as to assess the transmission risk and explore the prevention and control strategy.

Methods: The data of the malaria epidemic situation in the network direct report system of Guangxi in 2014 and the annual report of malaria epidemic situation in 14 cities were collected. The epidemiological information of the imported malaria cases was analyzed.

[First report of one imported case of schistosomiasis haematobia in Guangxi Zhuang Autonomous Region].

The first case of imported schistosomiasis haematobia in Guangxi Zhuang Autonomous Region is reported in this paper, so as to improve the doctors' understanding of the common tropic diseases abroad.

Pathological Lesions and Inducible Nitric Oxide Synthase Expressions in the Liver of Mice Experimentally Infected with Clonorchis sinensis.

The nitric oxide (NO) formation and intrinsic nitrosation may be involved in the possible mechanisms of liver fluke-associated carcinogenesis. We still do not know much about the responses of inducible NO synthase (iNOS) induced by Clonorchis sinensis infection. This study was conducted to explore the pathological lesions and iNOS expressions in the liver of mice with different infection intensity levels of C.

[A case of neonatal congenital malaria accompanied with severe thrombocytopenia].

This article reports the process of diagnosis and treatment of one case of neonatal congenital malaria accompanied with severe thrombocytopenia.

[Effect of malaria surveillance and control of Guangxi Zhuang Autonomous Region in 2013].

Objective: To evaluate the effect of malaria surveillance and control of Guangxi Zhuang Autonomous Region in 2013, and explore the suited surveillance and management of imported malaria cases, so as to provide the evidence for formulating the scientific control measures of imported malaria.

Methods: The endemic data and control measures of malaria in Guangxi in 2013 were collected and analyzed statistically.

Results: A total of 1 251 malaria cases were found in Guangxi in 2013, with 88.

Real-time evaluation of polyphenol oxidase (PPO) activity in lychee pericarp based on weighted combination of spectral data and image features as determined by fuzzy neural network.

A novel method of using hyperspectral imaging technique with the weighted combination of spectral data and image features by fuzzy neural network (FNN) was proposed for real-time prediction of polyphenol oxidase (PPO) activity in lychee pericarp. Lychee images were obtained by a hyperspectral reflectance imaging system operating in the range of 400-1000nm. A support vector machine-recursive feature elimination (SVM-RFE) algorithm was applied to eliminating variables with no or little information for the prediction from all bands, resulting in a reduced set of optimal wavelengths.

Inducible nitric oxide synthase response and associated cytokine gene expression in the spleen of mice infected with Clonorchis sinensis.

Clonorchis sinensis is a food-borne parasite that induces a permanent increase of nitrosation in the body upon infection. The spleen is an important secondary lymphoid organ for the regulation of immune responses locally and in the whole body. However, the functions and mechanisms of the spleen in nitric oxide (NO) responses after C.

Increasing prevalence and intensity of foodborne clonorchiasis, Hengxian County, China, 1989-2011.

During 1989-2011, three parasitic disease surveys were conducted in Hengxian County, China, where soil-transmitted helminthiases and foodborne clonorchiasis are endemic. We compared the data and found that the prevalence of helminthiases decreased and the prevalence and intensity of clonorchiasis increased over time, especially among men. Clonorchiasis control/intervention measures are urgently needed in this area.

[Identification of Clonorchis sinensis metacercariae based on PCR targeting ribosomal DNA ITS regions and COX1 gene].

Objective: To identify Clonorchis sinensis metacercariae using PCR targeting ribosomal DNA ITS region and COX1 gene.

Methods: Pseudorasbora parva were collected from Hengxian County of Guangxi at the end of May 2013. Single metacercaria of C.

Accuracy of the Kato-Katz method and formalin-ether concentration technique for the diagnosis of Clonorchis sinensis, and implication for assessing drug efficacy.

Background: Clonorchiasis is a chronic neglected disease caused by a liver fluke, Clonorchis sinensis. Chemotherapy is the mainstay of control and treatment efficacy is usually determined by microscopic examination of fecal samples. We assessed the diagnostic accuracy of the Kato-Katz method and the formalin-ether concentration technique (FECT) for C.

[Surveillance of malaria in Global Fund Malaria Project counties of Guangxi Zhuang Autonomous Region in 2011].

Objective: To analyze the monitoring results and epidemic trend of malaria in the Global Fund Malaria Project counties of Guangxi Zhuang Autonomous Region in 2011, so as to provide the evidence for improving the preventive measures.

Methods: The data about malaria surveillance were collected and statistically analyzed in 7 Global Fund Malaria Project counties of Guangxi in 2011.

Results: A total of 8 cases of malaria were reported in the Global Fund Malaria Project counties of Guangxi in 2011, the average annual incidence rate was 0.

Efficacy and safety of tribendimidine against Clonorchis sinensis.

Background: Clonorchiasis is of considerable public health importance, particularly in the People's Republic of China (PR China), where most of the 15 million individuals infected with Clonorchis sinensis are currently concentrated. Praziquantel is the drug of choice, but tribendimidine might be an alternative.

Methods: We performed a randomized open-label trial in Guangxi, PR China, to assess the efficacy and safety of 400 mg tribendimidine once, 400 mg tribendimidine daily for 3 days, and 75 mg/kg praziquantel in 1 day divided in 3 doses against parasitological-confirmed C.

[Analysis of COX1 sequences of Taenia isolates from four areas of Guangxi].

Objective: To analyze the COX1 sequences of Taenia isolates from four areas of Guangxi Zhuang Autonomous Region, and to understand the distribution of Taenia asiatica in Guangxi.

Methods: Patients with taeniasis in Luzhai, Rongshui, Tiandong and Sanjiang in Guangxi were treated by deworming, and the Taenia isolates were collected. Cyclooxygenase-1 (COX1) sequences of these isolates were amplified by PCR, and the PCR products were sequenced by T-A clone sequencing.