Publications by authors named "Yi-Chao Xiao"
Background: Correlations between posttranslational modifications and atrial fibrillation (AF) have been demonstrated in recent studies. However, it is still unclear whether and how ubiquitylated proteins relate to AF in the left atrial appendage of patients with AF and valvular heart disease.
Methods: Through LC-MS/MS analyses, we performed a study on tissues from eighteen subjects (9 with sinus rhythm and 9 with AF) who underwent cardiac valvular surgery.
Article Synopsis
- Vascular fibrosis increases with age, and oxidative stress contributes to this damage, but the effectiveness of antioxidants like N-acetylcysteine (NAC) in reducing fibrosis is still uncertain.
- A study on wild-type C57BL/6 mice revealed that treating 60-week-old mice with NAC for 12 weeks reduced collagen deposition in the aortas compared to untreated mice.
- The findings indicate that while NAC does not change the total number of macrophages, it promotes a shift towards beneficial M2 macrophage polarization and implicates certain proteins (SIRT-1, SIRT-3, FOXO-1) in the aging-related fibrosis process.