Publications by authors named "Yi-Bo He"
The article provides an overview of the current understanding of the interplay between metabolic pathways and immune function in the context of triple-negative breast cancer (TNBC). It highlights recent advancements in single-cell and spatial transcriptomics technologies, which have revolutionized the analysis of tumor heterogeneity and the immune microenvironment in TNBC. The review emphasizes the crucial role of metabolic reprogramming in modulating immune cell function, discussing how specific metabolic pathways, such as glycolysis, lipid metabolism, and amino acid metabolism, can directly impact the activity and phenotypes of various immune cell populations within the TNBC tumor microenvironment.
View Article and Find Full Text PDFBackground: Chen's Peiyuan Tang (CSPYT) is a compound herbal formula that has shown the potential to enhance ovarian function and reduce autophagy in ovarian granulosa cells, which plays a crucial role in follicular development and maturation. The application of Chinese herbal medicine offers a promising alternative to traditional hormone replacement therapy (HRT).
Methods: This study explores CSPYT's therapeutic mechanisms in treating POF, focusing on its modulation of autophagy through network pharmacology and transcriptomics-based analysis, predicting potential interactions and pathways.
Background: Apoptosis and apoptotic genes play a critical role in the carcinogenesis and progression of bladder cancer. However, there is no prognostic model established by apoptotic genes.
Methods: Messenger RNA (mRNA), Expression data, and related clinical data were obtained from The Cancer Genome Atlas (TCGA) database and Gene Expression Omnibus (GEO) database.
Background: Cutaneous malignant melanoma is a very aggressive and metastatic form of skin cancer, typically linked with poor outcomes. Advances in genomic analysis have underscored the crucial role of T cells in tumor immunity. Immune checkpoint inhibitors have notably transformed melanoma treatment by boosting T cell activity.
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- This study investigates the role and importance of CALU in various cancers, primarily focusing on its impact on tumor progression and treatment resistance, especially in breast cancer.
- Researchers analyzed CALU expression and its link to patient outcomes across multiple cancer types, utilizing various databases and experimental methods.
- Findings showed that higher CALU levels are associated with worse prognoses, driven by genomic changes, and CALU plays a significant role in promoting epithelial-mesenchymal transition (EMT) in both cancer cells and cancer-associated fibroblasts (CAFs).
Article Synopsis
- Bladder cancer is a serious health issue linked to high mortality, and the study focuses on LIG1, a gene often deleted in tumor cells, to understand its role in bladder cancer (BLCA).
- Researchers used various bioinformatics tools to analyze gene expression data and construct networks to identify key genes related to LIG1 and BLCA, employing techniques like differential expression analysis and protein-protein interaction mapping.
- The study found that LIG1 is upregulated in bladder cancer samples, and further analysis included survival comparisons and functional experiments to confirm LIG1's role in the disease.
Article Synopsis
- The review discusses how metal ions like iron, copper, zinc, and selenium play complex roles in the development and immune evasion of gliomas, which are a type of brain tumor.
- *Dysregulated metal ion metabolism leads to glioma progression by increasing oxidative stress, promoting blood vessel formation (angiogenesis), and affecting immune cell functions.
- *Therapeutic strategies targeting metal ion pathways, combined with traditional treatments, may improve glioma treatment effectiveness and future research should focus on uncovering new biomarkers and treatment targets.
Article Synopsis
- Recurrent pregnancy loss (RPL) is a complex issue with various causes, and roughly half of the cases remain unexplained; this study explores the role of iron metabolism genes in RPL.
- Researchers analyzed gene expression data to identify key hub genes, specifically CISD2 and CYP17A1, linked to iron metabolism—both were found to have reduced expression in RPL samples.
- The findings indicate that these genes could serve as potential diagnostic markers for RPL, with implications for understanding immune interactions and cellular processes involved in the condition.
Objective: To study the feasibility, safety, and effectiveness of lateral thoracic adipofascial flaps in reconstructing the defects following breast-conserving surgery (BCS) in breasts with either no ptosis or mild ptosis.
Methods: 37 female patients who underwent BCS and lateral thoracic adipofascial flap breast reconstruction between June 2020 and July 2022 were analysed. Surgery-related complications, intraoperative positive margin, local recurrence, and cosmetic outcome were assessed.
Objective: The mortality rate of ovarian cancer (OC) is the highest among all gynecologic cancers. To predict the prognosis and the efficacy of immunotherapy, we identified new biomarkers.
Methods: The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression Project (GTEx) databases were used to extract ovarian cancer transcriptomes.
Objective: Women with an elevated basal FSH indicate diminished ovarian reserve and reduced oocyte and embryo numbers. DMSCs are likely to be involved in immune tolerance of pregnancy maintenance. We investigate the effect of follicle-stimulating hormones on the immunomodulatory functions of DMSCs.
View Article and Find Full Text PDFPrevious studies have reported that ginsenoside-Rg1 (G-Rg1) was able to mitigate the loss of dopaminergic neurons in animal models of Parkinson's disease (PD). The present study provided a systematic review and meta-analysis of preclinical studies to pool current evidence on the effect of G-Rg1 on neurogenesis in the treatment of PD. Eligible studies were identified through a search from six databases: PubMed, EMBASE, Web of Science, VIP, Chinese National Knowledge Infrastructure and the Wanfang database.
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- - Nischarin is an integrin-binding protein acting as a tumor suppressor in breast cancer, mainly affecting cell migration and invasion.
- - The study investigates how Nischarin regulates the epithelial-mesenchymal transition (EMT), which is crucial for cell movement, by analyzing mRNA and protein levels after its overexpression and knockdown.
- - Results show that Nischarin inhibits cell proliferation and migration by increasing E-cadherin levels and decreasing multiple EMT-related transcription factors, thus suppressing the EMT process.
Serum albumin (S-Alb) is a widely used biomarker of nutritional status and disease severity in patients with autoimmune diseases. We investigated the correlation between S-Alb and the severity of myasthenia gravis (MG).A total number of 166 subjects were recruited in the study.
View Article and Find Full Text PDFBackground: Few clinical trials have evaluated the efficacy and safety of Tripterygium wilfordii Hook F (TwHF) compared with acitretin in psoriasis. We aimed to compare the efficacy and safety of TwHF compared with acitretin in the treatment of moderate to severe psoriasis vulgaris.
Methods: Adults with Psoriasis Area Severity Index (PASI) score ≥ 10 and psoriasis-affected body surface area ≥ 10% were randomized into a TwHF (20 mg, 3 times a day) or acitretin group (30 mg, once a day).
Natural product Hypericum perforatum L. has been used in folk medicine to improve mental performance. However, the effect of H.
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