Publications by Yi-An Ling

Publications by authors named "Yi-An Ling"

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Oncogenic FLT3 internal tandem duplication activates E2F1 to regulate purine metabolism in acute myeloid leukaemia.

Zi-Yao Ou Ke Wang Wen-Wen Shen Ge Deng Ya-Yun Xu Yi-An Ling

Biochem Pharmacol

April 2023

Oncogene FLT3 internal tandem duplication (FLT3-ITD) mutation accounts for 30 % of acute myeloid leukaemia (AML) cases and induces transformation. Previously, we found that E2F transcription factor 1 (E2F1) was involved in AML cell differentiation. Here, we reported that E2F1 expression was aberrantly upregulated in AML patients, especially in AML patients carrying FLT3-ITD.

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