Tunneling nanotube-like structures regulate distant cellular interactions during heart formation.

In the developing mammalian heart, the endocardium and the myocardium are separated by so-called cardiac jelly. Communication between the endocardium and the myocardium is essential for cardiac morphogenesis. How membrane-localized receptors and ligands achieve interaction across the cardiac jelly is not understood.

Parkin characteristics and blood biomarkers of Parkinson's disease in WPBLC study.

Background: The exact mechanisms of PD are unclear, but Parkin-mediated mitophagy dysfunction is believed to play a key role. We investigated whether blood levels of Parkin and other biomarkers are linked to the risk of developing PD.

Methods: Baseline blood measures of Parkin and other biomarkers, including Homocysteine, carcinoembryonic antigen, Urea, total proteins, total cholesterol, creatine kinase, and albumin, were collected from 197 clinically diagnosed Parkinson's disease participants and 107 age-matched healthy controls in Wenzhou Parkinson's Biomarkers and Living Characteristics study.

Facile Synthesis of MoP and Its Composite Structure with Ru as an Efficient Electrocatalyst for Hydrogen Evolution Reaction in Both Acidic and Alkaline Conditions.

Developing low-cost electrocatalysts for efficient hydrogen evolution in both acidic and alkaline conditions is crucial for water-electrolytic hydrogen applications. Herein, MoP was synthesized via a simple, low-cost, and green phosphorization route. More importantly, the Ru/MoP composite prepared using the as-synthesized MoP as a reactant, which exhibited excellent catalytic activity for the hydrogen evolution reaction.

Non-aqueous electrowetting liquid lens with centimeter-level large aperture based on dielectric failure suppression principle.

Liquid lens offers a novel approach to achieving large depth of field, wide viewing angle, high speed, and high-quality imaging in zoom optical systems. However, the aperture and reliability limit the lens's performance in various optical applications. The liquid material is crucial for the reliability of the large-aperture liquid lens.

Lateral Meniscus Repairs Using Single Posteromedial Portal by All-Inside Suture-From Posterior to Anterior.

The meniscus plays an important role in absorbing shock, sharing load, reducing contact stress, and maintaining stability of knee joint movement. We know that there are various ways to repair meniscus injuries under arthroscopy. However, we found some technical limitations during the operation, such as the risk of neurovascular injury and the long operation time of repair.

LncRNA LINC01128 promotes prostate cancer cell proliferation, metastasis, and epithelial-mesenchymal transition by modulating miR-27b-3p.

Background: Prostate cancer (PCa) is a prevalent malignancy within the male reproductive system that poses a significant threat to patients' lives. The function of long non-coding RNA LINC01128 in PCa progression remains to be elucidated.

Objective: The objective was to evaluate the significance of LINC01128 in PCa and to elucidate the underlying mechanisms, thereby identifying a potential target for PCa treatment.

IDR-driven TOLLIP condensates antagonize the innate antiviral immunity by promoting the deSUMOylation of MAVS.

Mitochondrial antiviral signaling protein (MAVS) is a central adaptor protein in retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) signaling against RNA viral infection. Posttranslational modifications (PTMs) play a critical role in modulating the activity of MAVS. However, how phase separation regulates the PTMs to fine-tune MAVS activation remains to be elucidated.

RAB4B and Japanese encephalitis virus E protein interaction is essential for viral entry in early endosomes.

RAB4B (Ras-Related GTP-Binding Protein 4b) is essential for intracellular trafficking and endosomal recycling processes. Our previous study, we demonstrated that RAB4B promotes Japanese encephalitis virus (JEV) replication in PK15 cells. However, the exact mechanisms underlying the role of RAB4B in JEV internalization remain unclear.

Effect of CICC 32883 Fermentation on the Structural Features and Antioxidant Protection Effect of Chinese Yam Polysaccharide.

In this study, Chinese yam polysaccharide (CYP) was fermented by CICC 32883, and its structural features and antioxidant activities before and after fermentation were analyzed. CICC 32883-fermented CYP (CYP-SC) had higher carbohydrate content and lower protein content than the nonfermented CYP (CYP-NF). The monosaccharide composition of CYP-SC was unaffected, but the proportion was changed.

The Relationship Between Soccer Participation and Team Cohesion for Adolescents: A Chain-Mediated Effect of Athlete Engagement and Collective Self-Esteem.

This study was carried out to explore the mechanism between athlete participation and team cohesion for adolescent school soccer players. We examined the mediating role of athlete engagement and collective self-esteem between athlete participation and team cohesion for adolescent soccer players. A comprehensive investigation of 1659 primary and middle school soccer players was conducted using the Athlete Participation Scale, Athlete Engagement Questionnaire, Collective Self-Esteem Scale, and Team Cohesion Scale, and we conducted correlation, regression and pathway analyses among the variables.

Improved Medial-Internal Approach to Repair Posterior Root of Medial Meniscus by All-Suture Anchor Combined With Opening Wedge High Tibial Osteotomy.

Medial meniscus posterior root tears often occur in patients with lower limb varus malalignment, which leads to mechanical overloading of the medial compartment and premature cartilage wear. Such injuries are often treated by the pullout technique or the suture anchor technique. In this context, the technique of repairing the posterior root of the medial meniscus using all-suture anchors combined with an opening wedge high tibial osteotomy has been proposed.

Integrated sensing and communication based on space-time-coding metasurfaces.

Programmable metasurfaces (PMs), also called reconfigurable intelligent surfaces (RISs), are planar structures capable of dynamically manipulating electromagnetic waves in real-time. Regarded as a key enabling technology for implementing smart wireless propagation environments, PMs/RISs also serve as an ideal supporting platform for integrated sensing and communication (ISAC). Here, we propose two ISAC schemes based on a special type of PMs/RISs: space-time-coding metasurfaces (STCMs).

Investigating the relationship between inflammatory cytokines and adolescent depression: a comparative analysis.

Background: Major depressive disorder (MDD) in adolescents poses a significant threat to physical health. Previous studies have indicated that adolescents with MDD exhibit immune activation.

Objective: This study aimed to compare cytokine levels in adolescents with MDD to healthy controls and assess their diagnostic value.

Aberrant Modular Dynamics of Functional Networks in Schizophrenia and Their Relationship with Neurotransmitter and Gene Expression Profiles.

Introduction: Numerous studies have emphasized the time-varying modular architecture of functional brain networks and its relevance to cognitive functions in healthy participants. However, how brain modular dynamics change in schizophrenia and how these alterations relate to neurotransmitter and transcriptomic signatures have not been well elucidated.

Methods: We harmonized resting-state fMRI data from a multi-site sample including 223 patients and 279 healthy controls and applied the multilayer network method to estimate the regional module switching rate (flexibility) of functional brain connectomes.

Association of serum N,N,N-trimethyl-5-aminovaleric acid, trimethylamine N-oxide, and trimethyllysine levels with gestational diabetes mellitus.

Objective: To investigate the association of serum N,N,N-trimethyl-5-aminovaleric acid (TMAVA), trimethylamine N-oxide (TMAO), and trimethyllysine (TML) levels with gestational diabetes mellitus (GDM).

Methods: Seventy pregnant women from the Hunan Provincial Maternal and Child Health Care Hospital (March 2021 to October 2023) were enrolled in this study. Forty GDM patients with GDM were included in the GDM group (GDM), and 30 healthy controls were included (Con).

[Thoughts on the rescue process of a patient with septic shock].

Septic shock is a common acute and critical illness in intensive care medicine. It can lead to multiple organ failure, of which the heart is one of the target organs. Fluid resuscitation plays an important role in the treatment of septic shock, but when a patient develops septic-induced cardiomyopathy, the circulation is often not improved by fluid resuscitation, and may even lead to deterioration of circulation.

Structural characterization and antioxidant activity of a polysaccharide produced by CGMCC 6882 from waste tobacco leaves.

Due to the restricts of treatment methods and high costs, waste tobacco materials are usually discarded, which leads to resources waste and environmental pollution. Present work used waste tobacco leaves as carbon source to produce polysaccharide (CGP-TL) by CGMCC 6882 via submerged fermentation. CGP-TL yield was 1.

Individualized diagnosis of Parkinson's disease based on multivariate magnetic resonance imaging radiomics and clinical indexes.

Objective: To explore MRI-based radiomics models, integrating clinical characteristics, for differential diagnosis of Parkinson's disease (PD) to evaluate their diagnostic performance.

Methods: A total of 256 participants [153 PD, 103 healthy controls (HCs)] from the First Affiliated Hospital of Wenzhou Medical Hospital, were enrolled as the training set, and 120 subjects (74 PD, 46 HCs) from the PPMI dataset served as the test set. Radiomics features were extracted from structural MRI (T1WI and T2-FLair).

Deep learning and radiomics for gastric cancer lymph node metastasis: Automated segmentation and multi-machine learning study from two centers.

Objective: The objective of this study is to develop an automated method for segmenting spleen computed tomography (CT) images using a deep learning model. This approach is intended to address the limitations of manual segmentation, which is known to be susceptible to inter-observer variability. Subsequently, a prediction model of gastric cancer (GC) lymph node metastasis was constructed in conjunction with radiomics and deep learning features, and a nomogram was generated to explore the clinical guiding significance.

Neutrophil-derived vesicles control complement activation to facilitate inflammation resolution.

Although subsets with immunosuppressive properties exist, neutrophils are typically known for their pro-inflammatory role and pathogen clearance capabilities. Here, we reveal that neutrophils can paradoxically aid in resolving inflammation by actively producing anti-inflammatory extracellular vesicles. These large aging-neutrophil-derived vesicles (LAND-Vs) do not fit into classical vesicle categorizations due to their specific size, structure, or biogenesis pathway.

Listerin promotes α-synuclein degradation to alleviate Parkinson's disease through the ESCRT pathway.

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive accumulation of abnormal α-synuclein (α-syn) within dopaminergic neurons in the substantia nigra region of the brain. Despite excessive accumulation of α-syn being key to the pathogenesis of PD, the mechanisms governing its clearance remain elusive. In this study, we found that the endosomal sorting complex required for transport (ESCRT) system plays a crucial role in capturing and facilitating the degradation of ubiquitinated α-syn.

Reduction of DNA Topoisomerase Top2 Reprograms the Epigenetic Landscape and Extends Health and Life Span Across Species.

DNA topoisomerases are essential molecular machines that manage DNA topology in the cell and play important roles in DNA replication and transcription. We found that knocking down the enzyme topoisomerase Top2 or its mammalian homolog TOP2B increases the lifespan of S. cerevisiae, C.

Breast Carcinomas Resembling Acinic Cell Carcinoma: Comprehensive Analysis of 14 Cases and Review of the Literature.

Acinic cell carcinoma (AciCC) of the breast is an exceptionally rare subtype of invasive breast carcinoma, often exhibiting a triple-negative phenotype and relatively indolent behavior. Since the first case reported by Roncaroli and colleagues in 1996, no more than 60 additional cases have been described in English medical journals, usually as case reports or small case series. In this study, we presented an in-depth analysis of 14 cases of AciCC of the breast, including 4 pure AciCCs and 10 AciCCs mixed with other histologic types.

Real-time holographic camera for obtaining real 3D scene hologram.

As a frontier technology, holography has important research values in fields such as bio-micrographic imaging, light field modulation and data storage. However, the real-time acquisition of 3D scenes and high-fidelity reconstruction technology has not yet made a breakthrough, which has seriously hindered the development of holography. Here, a novel holographic camera is proposed to solve the above inherent problems completely.

The effect of the allosteric regulation on the catalytic activity of fructosyltransferase studied molecular dynamics simulations.

Fructosyltransferase (FTase) is a key glycosidase with hydrolytic and transglycosylation functions that can utilize sucrose to generate oligofructose (FOS), which is extremely important in the food industry as well as in plants and microorganisms. However, there remain significant gaps in our understanding of the catalytic mechanism of FTase, particularly regarding the effect of regulatory mechanisms of residues on enzyme catalytic activity. In this study, molecular dynamics simulations and immobilized enzyme catalysis experiments were employed to investigate the structural dynamics and catalytic activity of QU10-FTase.