Publications by authors named "Yi Zhen Joan Lee"
Article Synopsis
- The research aimed to explore how physical examination techniques affect diagnostic accuracy, highlighting the importance of these skills in clinical care.
- The study involved assessing 113 medical interns through direct observation by faculty, focusing on their performance across seven domains related to physical examination and clinical judgment.
- Results showed a strong link between physical examination technique and the accurate identification of signs and differential diagnosis, while a decrease in performance was noted over the internship period, suggesting a need for improved emphasis on physical examination skills in training.
Objectives: This study prospectively evaluated endomyocardial biopsies in patients with heart failure with preserved ejection fraction (HFpEF) to identify histopathologic phenotypes and their association with clinical characteristics.
Background: Myocardial tissue analysis from a prospectively defined HFpEF cohort reflecting contemporary comorbidities is lacking.
Methods: Patients with HFpEF (EF ≥50%) referred to the Johns Hopkins HFpEF Clinic between August 2014 and September 2018 were enrolled for right heart catheterization and endomyocardial biopsy.
Background: Feedback based on direct observation of the physical examination (PE) is associated with enhanced educational outcomes, yet attending physicians do not frequently observe graduate trainees performing the PE.
Methods: We recruited volunteer patients (VPs), each with an abnormality of the cardiovascular, respiratory, or neurological system. Interns examined each VP, then presented a differential diagnosis and management plan to two clinician educators, who, themselves, had independently examined the VPs.
Peripartum cardiomyopathy (PPCM) is an uncommon complication of pregnancy. Early case reports identified overlap between familial dilated cardiomyopathy (DCM) and PPCM, although the degree of overlap is largely unknown. Other evidence supporting a contribution from gene mutations in PPCM includes familial occurrence, genome-wide association studies, variable prevalence among different regions and ethnicities, and more recent investigations of panels of genes for mutations among women with PPCM.
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- Amyloidosis involves a buildup of amyloid deposits in tissues, with ATTR amyloidosis being a notable subtype that can occur with or without specific genetic mutations.
- Diagnosis typically involves a tissue biopsy followed by advanced testing techniques like liquid chromatography tandem mass spectrometry (LC-MS/MS) to identify the amyloid type, but genetic testing may also be necessary.
- A study found that while LC-MS/MS identified mutations in 84% of patients with biopsy-confirmed ATTR amyloidosis, it missed several key mutations, highlighting the importance of genetic testing for accurate diagnosis and treatment planning.