Publications by authors named "Yi Yao"

Traumatic brain injury (TBI) is one of the leading public health concerns in the world. Therapeutic hypothermia is routinely used in severe TBI, and pathophysiological hyperthermia, frequently observed in TBI patients, has an unclear impact on drug transport in the injured brain due to a lack of study on its effects. We investigated the effect of post-traumatic therapeutic hypothermia at 33°C and pathophysiological hyperthermia at 39°C on brain transport and cell uptake of neuroprotectants after TBI.

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In recent years, consumer demand for healthy foods containing natural food additives has increased. Eugenol (EUG) is an essential oil popular as a natural antiseptic. However, its limited water solubility, high volatility, strong odor, and fragile stability hinder its application and storage in the field of food preservation.

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Although serum uric acid (SUA) is a risk factor for cardiometabolic outcome, but it remains unclear which patients with coronary artery disease (CAD) benefit the most from SUA lowering therapy (ULT). The association of SUA level, systemic inflammation and cardiometabolic risk is still unclear. The current study is aimed to examine whether SUA-associated cardiometabolic risk is modulated by systemic inflammation in CAD patients.

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Anthocyanins are important secondary metabolites in plants. After the formation of anthocyanidins, Flavonoid 3-O-glucosyltransferase (3GT) mediated glycosylation first occurs at the C-3 site, forming a stable anthocyanin 3-O-glucoside. Several studies have investigated the function of 3GT using biochemical methods.

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Background: The optimal glycosylated hemoglobin (HbA1c) target in type 2 diabetes mellitus (T2DM) patients remains controversial, especially in patients with concomitant coronary heart disease (CHD). This study aimed to investigate the correlation between baseline HbA1c and long-term prognosis in CHD patients with T2DM.

Methods: The study enrolled 6,839 CHD patients with T2DM and measured HbA1c at admission in a multicenter prospective observational cohort.

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Article Synopsis
  • High temperatures above 600 °C create challenges for metal lubrication due to softening and oxidation, making traditional lubricants ineffective.
  • Researchers found that additively-manufactured Inconel superalloy can achieve low coefficients of friction (COF) between 0.10-0.32 at temperatures reaching 900 °C by forming protective spinel-based oxide layers.
  • A computational approach was developed to predict the lubricating properties of different oxide compositions, highlighting the potential of spinel oxide for self-lubricating high-temperature alloys, outperforming traditional lubricants.
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  • Embryonic stem cells can self-organize into structures similar to blastocysts, which are important for studying early development and potential therapies.
  • Researchers identified key factors influencing blastoid formation, focusing on the gene Nr1h2, which is critical for its development and operation across multiple species.
  • Activation of Nr1h2 not only promotes blastoid creation but also enhances their ability to implant in the uterus and contribute to both embryonic and extraembryonic tissues, highlighting its broad regulatory role in early embryonic development.
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Objective: To search for a new biomarker that can predict the efficacy and prognosis of tumor immunotherapy.

Method: FOXK2 genes were analyzed using single-cell sequencing in pan-cancer bulk RNA-seq from the TCGA database. We used algorithms to predict their immune infiltration.

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Background: Endothelial cells are the first and most damaged target cells during acute lung injury (ALI). Endothelial dysfunction increases pulmonary microvascular permeability, subsequently leading to pulmonary oedema and organ dysfunction; however, clinical treatments against microvascular permeability show poor efficacy. Herein, we aimed to explore the role of the Sigma-1 receptor (Sig-1R) in pulmonary microvascular permeability by constructing ALI animal and cell models, and further investigated the specific mechanisms.

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Objective: The primary objective of this retrospective analysis was to evaluate the incidence and lateralization value of peri-ictal yawning (PY) in people with temporal lobe epilepsy (TLE). PY has only occasionally been reported as a manifestation of focal epilepsy. We aimed to determine whether PY could serve as an indicator to help lateralize seizure onset during epileptic seizures.

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Purpose: To explore the association between the systemic immune-inflammation index (SII) score and prognosis in immune checkpoint inhibitor (ICI)-treated patients with lung cancer.

Methods: PubMed, EMBASE, Web of Science, and CNKI databases were searched up to August 1, 2024. Progression-free survival (PFS) and overall survival (OS) were the primary outcomes queried.

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Malaria remains a major public health concern. The rapid spread of resistance to antimalarial drugs is a major challenge for malaria eradication. Timely and accurate molecular monitoring based on practical detection methods is a critical step toward malaria control and elimination.

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Article Synopsis
  • 4D cone-beam computed tomography (CBCT) is important for adaptive radiation therapy in lung cancer, but low sampling data can cause image artifacts that complicate treatment.
  • Existing deep learning methods often need large labeled datasets to work effectively, which are hard to get in real-world situations, leading to difficulties in maintaining motion and recovering details.
  • The introduced Deep Prior Image Constrained Motion Compensation (DPI-MoCo) framework addresses these issues by separating the reconstruction process into artifact suppression and detail enhancement, achieving effective results without needing paired datasets and performing well in both simulations and clinical tests.
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Previously, we found that the expression of Toll-like receptor 4 (TLR4) is altered after sciatic nerve injury, and its differential expression plays a key role in recovery. However, the mechanisms by which TLR4 affects neuronal function in the dorsal root ganglion (DRG) have not been completely evaluated. The objective is to determine TLR4 expression in DRG tissues after sciatic neural injury and exploring the effects of TLR4 knockdown and overexpression in the DRG on neuronal function and nerve regeneration in rats in vivo and in vitro.

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Halide argyrodite solid-state electrolytes of the general formula LiPS exhibit complex static and dynamic disorder that plays a crucial role in ion transport processes. Here, we unravel the rich interplay between site disorder and dynamics in the plastic crystal argyrodite LiPSCN and the impact on ion diffusion processes through a suite of experimental and computational methodologies, including temperature-dependent synchrotron powder X-ray diffraction, AC electrochemical impedance spectroscopy, Li solid-state NMR, and machine learning-assisted molecular dynamics simulations. Sulfide and (pseudo)halide site disorder between the two anion sublattices unilaterally improves long-range lithium diffusion irrespective of the (pseudo)halide identity, which demonstrates the importance of site disorder in dictating bulk ionic conductivity in the argyrodite family.

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Aim: To evaluate the percentage and reasons for disagreements in the risk of bias (RoB) assessments for randomized controlled trials (RCTs) included in more than one Cochrane review in the field of nursing.

Background: Disagreement in RoB assessments reduces the credibility of the evidence summarized by systematic reviews (SRs). There is no study that evaluates the reliability of RoB assessments in nursing studies.

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Objective: This study aimed to investigate the frequently mutated genes in Gastric Cancer (GC), assess their association with Tumor Mutation Burden (TMB) and the patients' survival, and identify the potential biomarkers for tailored therapy.

Methods: Simple somatic mutation data of GC were collected from the TCGA and ICGC databases. The high-frequency mutated genes were identified from both datasets.

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Introduction: The evidence regarding the effectiveness of Lanzhou Lamb Rotavirus Vaccine (LLR) and RotaTeq (RV5) against gastroenteritis (RVGE) caused by emerging genotypes in Chinese children remains limited.

Methods: We conducted a test-negative case-control study using gastroenteritis surveillance data from four cities (2020-2023) in Guangdong Province, China. Children aged 2 months to 5 years hospitalized with acute gastroenteritis were enrolled.

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Article Synopsis
  • Carvone and limonene are natural scents used in perfumes, but they don't last long due to being unstable.
  • Scientists created special structures called inclusion complexes to keep these scents stable and make them last longer when heated.
  • The study found that these complexes work well at different temperatures, which could help use carvone and limonene in more products.
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This study used the Actor-Partner Interdependence Model to examine how parents' adult attachment influences their their own and the partners' co-parenting and parent-child relationships. Participants were from a cross-sectional sample of 1313 Chinese heterosexual married couples (fathers' M = 39.74, SD = 5.

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Background: Zishen Qingre Lishi Huayu recipe (ZQLHR) has shown significant therapeutic effects in treating sex hormone levels and follicular developmental disorders in patients with polycystic ovary syndrome (PCOS). However, little is known about the potential mechanisms of its treatment.

Methods: Dehydroepiandrosterone and a high-fat diet induced the PCOS model rat.

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