Investigating the therapeutic mechanism of Jiedu-Quyu-Ziyin Fang on systemic lupus erythematosus through the ERα-miRNA-TLR7 immune axis.

Jiedu-Quyu-Ziyin Fang (JQZF) is a formula that has been empirically used for the treatment of SLE in clinical practice. JQZF has become an approved hospital prescription in China. Fifteen MRL/lpr mice were randomly divided into three groups: Model, JQZF, and JQZF + GC, with five mice in each group.

Global distribution of zoonotic digenetic trematodes: a scoping review.

Background: Digenetic trematodes, including blood flukes, intestinal flukes, liver flukes, lung flukes, and pancreatic flukes, are highly diverse and distributed widely. They affect at least 200 million people worldwide, so better understanding of their global distribution and prevalence are crucial for controlling and preventing human trematodiosis. Hence, this scoping review aims to conduct a comprehensive investigation on the spatio-temporal distribution and epidemiology of some important zoonotic digenetic trematodes.

Task-related brain activation associated with violence in patients with schizophrenia: A meta-analysis.

This study investigates specific changes in brain function during cognitive and emotional tasks in patients with schizophrenia and a history of violence (VSCZ) compared with non-violent patients with schizophrenia and healthy controls. A comprehensive literature search was conducted at the Web of Science, Medline, and PubMed. Ten studies met the inclusion criteria.

Reliability and reproducibility of CBCT assessment of mandibular changes before and after treatment for Class III growing patients - an easy and quick way for evaluation.

The objective of this study was to evaluate intraobserver reliability and inter-observer reproducibility of a 3-dimensional (3D) assessment method for mandibular changes of growing patients after orthodontic treatment for Class III malocclusion.Methods Cone-beam computed tomography (CBCT) scans were performed before and after orthodontic treatment for 27 patients. During the scan, the patient was positioned such that his/her mandibular plane was parallel to floor.

Jiedu-Quyu-Ziyin Fang (JQZF) inhibits the proliferation and activation of B cells in MRL/lpr mice via modulating the AKT/mTOR/c-Myc signaling pathway.

Ethnopharmacological Relevance: Jiedu-Quyu-Ziyin Fang (JQZF) is a new herbal formula improved based on "Sheng Ma Bie Jia Tang" in the Golden Chamber, has been proved to be effective in the treatment of SLE. The ability of JQZF to prevent lymphocyte growth and survival has been demonstrated in earlier investigations. However, the specific mechanism of JQZF on SLE has not been fully investigated.

Clinical guideline on magnetically controlled capsule gastroscopy (2021 edition).

With the development and generalization of endoscopic technology and screening, clinical application of magnetically controlled capsule gastroscopy (MCCG) has been increasing. In recent years, various types of MCCG are used globally. Therefore, establishing relevant guidelines on MCCG is of great significance.

Changing patterns of the East Asian monsoon drive shifts in migration and abundance of a globally important rice pest.

Numerous insects including pests and beneficial species undertake windborne migrations over hundreds of kilometers. In East Asia, climate-induced changes in large-scale atmospheric circulation systems are affecting wind-fields and precipitation zones and these, in turn, are changing migration patterns. We examined the consequences in a serious rice pest, the brown planthopper (BPH, Nilaparvata lugens) in East China.

Multi-omics analyses of tumor-associated immune-infiltrating cells with the novel immune checkpoint protein tyrosine phosphatase 1B (PTP1B) in extracellular matrix of brain-lower-grade-glioma (LGG) and uveal-melanoma (UVM).

Immune checkpoint inhibitors represented by PD-1 have greatly changed the way cancer is treated. In addition to PD-1, new immune checkpoints are constantly excavated to better treat cancer. Recently, protein tyrosine phosphatase 1B (PTP1B) was identified as a new immune checkpoint and played a critical role in the treatment of tumors by inhibiting the proliferation and cytotoxicity of T cells induced by tumor antigen.

Comprehensive analysis of tumor necrosis factor-α-inducible protein 8-like 2 (TIPE2): A potential novel pan-cancer immune checkpoint.

Tumor necrosis factor-α-inducible protein 8-like 2 (TIPE2) is encoded by TNFAIP8L2 and is a newly identified negative regulator of natural and acquired immunity that plays a critical function in maintaining immune homeostasis. Recently, CAR-NK immune cell therapy has been a focus of major research efforts as a novel cancer therapeutic strategy. TIPE2 is a potential checkpoint molecule for immune cell maturation and antitumor immunity that could be used as a novel NK cell-based immunotherapeutic approach.

 (Amaryllidaceae), a new species from Henan, China.

D.F.Xie & X.

A Novel Method Based on Combination of Independent Component Analysis and Ensemble Empirical Mode Decomposition for Removing Electrooculogram Artifacts From Multichannel Electroencephalogram Signals.

Electrooculogram (EOG) is one of common artifacts in recorded electroencephalogram (EEG) signals. Many existing methods including independent component analysis (ICA) and wavelet transform were applied to eliminate EOG artifacts but ignored the possible impact of the nature of EEG signal. Therefore, the removal of EOG artifacts still faces a major challenge in EEG research.

A better prediction of progression-free survival in diffuse large B-cell lymphoma by a prognostic model consisting of baseline TLG and %ΔSUV.

In the era of rituximab, the International Prognostic Index (IPI) has been inefficient in initial risk stratification for patients with R-CHOP-treated diffuse large B-cell lymphoma (DLBCL). To estimate the predictive values of PET/CT quantitative parameters and three prognostic models consisting of baseline and interim parameters for three-year progression-free survival (PFS), we conducted an analysis of 85 patients in China with DLBCL underwent baseline and interim PET/CT scans and treated at the Department of Hematology of Peking University Third Hospital from November 2012 to November 2017. The PET/CT parameters, viz.

Sphingosine kinase 1 knockout alleviates hepatic ischemia/reperfusion injury by attenuating inflammation and oxidative stress in mice.

Background: Hepatic ischemia/reperfusion (I/R) injury remains a significant problem in clinical practice. Sphingosine kinase 1 (SphK1) phosphorylates sphingosine to sphingosine-1-phosphate (S1P) which participates in multiple bioactive processes. However, little is known about the role of SphK1 in hepatic I/R injury.

Self-enhancement of CO reversible absorption accompanied by phase transition in protic chlorocuprate ionic liquids for effective CO separation from N.

An efficient strategy for the high-capacity capture of CO is reported, and a phase change in protic chlorocuprate ionic liquids (PCILs) from liquid to solid is found during CO absorption. The highest CO capacity is 0.96 molCO molIL-1, being at least 150 times higher than that in [BMIM][PF6].

Stable Na Plating and Stripping Electrochemistry Promoted by In Situ Construction of an Alloy-Based Sodiophilic Interphase.

Sodium metal anodes are poor due to the reversibility of Na plating/stripping, which hinders their practical applications. A strategy to form a sodiophilic Au-Na alloy interphase on a Cu current collector, involving a sputtered Au thin layer, is shown to enable efficient Na plating/stripping for a certain period of time. Herein, electrochemical behaviors of Na plating on different substrates are explored, and it is revealed that the sodiophilic interphase can be achieved universally by in situ formation of M-Na (M = Au, Sn, and Sb) alloys during Na plating prior to Na bulk deposition in the initial cycle.

Regulation of P300 and HDAC1 on endoplasmic reticulum stress in isoniazid-induced HL-7702 hepatocyte injury.

P300 and HDAC1 can be involved in the development of various liver diseases by regulating gene transcription. Endoplasmic reticulum stress (ERS) is one of the main pathways of apoptosis and is activated during inflammatory responses, but the roles of P300 and HDAC1 in ERS in antituberculosis drug-induced liver injury (ADLI) are not clear. This study confirms that isoniazid can change the states of P300 and HDAC1 in HL-7702 hepatocyte metabolism and induce ERS, causing hepatocyte injury and apoptosis.

[Value of F-FDG PET/CT Scan Quantization Parameters for Prognostic Evaluation of Patients with Diffuse Large B-cells Lymphoma].

Objective: To investigate the prognostic value of F-FDG PET/CT scan quantization parameters, max standardized uptake value （SUVmax）, metabolic tumor volume （MTV）, total lesion glycolysis （TLG） and other clinical factors for prognostic evaluation of paticnts with diffuse large B-cell lymphoma （DLBCL）.

Methods: PET/CT scan and clinical data of a total of 65 newly diagnosed DLBCL patients who received Rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone （R-CHOP） chemotherapy as first-line treatment were analyzed. All patients received a PET/CT scan at diagnosis and an interim PET/CT after 2-4 circles of chemotherapies.

Involvement of histone hypoacetylation in INH-induced rat liver injury.

This study explores the mechanism of histone acetylation under the effect of oxidative stress in rat liver injury induced by isoniazid (INH). Fifty-six adult SD rats were selected and divided randomly into INH groups (48) and control (8). Rats in INH groups were intragastrically injected with 55 mg kg day for 3, 7, 10, 14, 21, and 28 days, and control rats were given an equal volume of distilled water.

Dilation Time in Endoscopic Papillary Balloon Dilation for Common Bile Duct Stones.

Background: To assess the short-term outcomes after endoscopic sphincterotomy (EST) plus endoscopic papillary balloon dilation (EPBD) versus EPBD alone and appropriate balloon dilation time in EPBD alone.

Materials And Methods: A total of 413 patients with common bile duct stones (CBDSs) were included in the EST plus EPBD group and 84 were in the EPBD alone group. We retrospectively evaluated the safety and efficacy between EST plus EPBD and EPBD alone group.

[Effects of interaction of genotypes with environments on major latently fragrant substances of flue-cured tobacco in Baoshan of Yunnan, Southwest China].

To study the stability of major latently fragrant substances of flue-cured tobacco of different varieties in Baoshan of Yunnan, three tobacco cultivars (K326, Y87 and Y99) in two soil types at three test sites with different altitudes were tested. The contents of major latently fragrant substances were measured and the effects of genotypes, environments and their interactions were analyzed by AMMI model. The results showed that genotypes, environments and their interactions had significant effects on the contents of lutein, β-carotene, and chlorogenic acid.

[Soil nutrients spatial variability and soil fertility suitability in Qujing tobacco-planting area].

By adopting GPS technique, 2088 sampling sites were installed in the tobacco-planting area of Qujing City, Yunnan Province, with 0-20 cm soil samples collected to determine their main nutrients contents. The overall characteristics and spatial variability of the tobacco soil nutrients were analyzed by classic statistics and geo-statistics, and the soil fertility suitability in planting tobacco was evaluated by the methods of fuzzy mathematics. In the study area, soil pH and soil organic matter, available S, and water-soluble Cl contents were appropriate, soil total N and alkalihydrolyzable N contents were too high, soil available K, Ca, Mg, Cu, Fe, Zn, Mo, and Mn contents were abundant, soil available P content was at medium level, while soil total P and K and available B contents were insufficient.

[Regional characteristics of sulfur contents in flue-cured tobacco in Hunan Province and their influence to smoking quality].

A total of 559 flue-cured tobacco samples with 3 grades (B2F, C3F and X2F) were collected from the main tobacco-growing areas in Hunan Province, and their sulfur contents were determined to study the regional characteristics of the sulfur contents and their quantitative correlations with the evaluation indices of smoking quality. The results showed that the sulfur content in the flue-cured tobacco was 0.100%-2.