HRS mediates tumor immune evasion by regulating proteostasis-associated interferon pathway activation.

By sorting receptor tyrosine kinases into endolysosomes, the endosomal sorting complexes required for transport (ESCRTs) are thought to attenuate oncogenic signaling in tumor cells. Paradoxically, ESCRT members are upregulated in tumors. Here, we show that disruption of hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), a pivotal ESCRT component, inhibited tumor growth by promoting CD8 T cell infiltration in melanoma and colon cancer mouse models.

Mini-review of studies on the carcinogenicity of deoxynivalenol.

The purpose of this article is to make a summary of the information regarding the researches on the carcinogenicity of DON and to discuss implications on future researches. Publications of experiments were collected through databases, experts, previous reviews, citation tracking. To guarantee the quality of the studies included in this review, we set up different criteria for different kinds of studies.