Publications by authors named "Yi Xin Wu"
Background: Sclerotherapy is purportedly less effective in patients with hemorrhagic than with non-hemorrhagic lymphatic malformations (LMs). We aimed to compare the efficacy of bleomycin-lauromacrogol foam (BLF) sclerotherapy in the treatment of macrocystic LMs with and without intralesional hemorrhage.
Methods: Fifty-five children with macrocystic LMs admitted to the Pediatric Surgery Department were retrospectively included.
Article Synopsis
- A study investigated clinical differences between early-onset and late-onset SARS-CoV-2 infections in neonates, focusing on symptoms, treatments, and outcomes during hospitalization.
- The research included 58 neonates admitted to the neonatal intensive care unit, with 28% classified as early-onset (within 7 days of birth) and 72% as late-onset (more than 7 days after birth).
- Findings revealed that late-onset cases were more likely to present with symptoms like fever and cough, and they had a higher incidence of pneumonia, indicating a need for different management strategies for each group.
Microplastics (MPs), as a new type of pollutant, are widely detected in sewage treatment plants. Currently, research on MPs in traditional sewage treatment systems has mainly been focused on the pollution level and distribution characteristics, with a lack of studying the impact of MPs on the sludge granulation. In order to explore the effect of MPs on the granulation process, a microplastic exposure test was conducted by adding polyethylene terephthalate microplastics (PET-MPs), which are widespread in the environment.
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- Piscidins are important for the fish immune response, helping to fight off foreign microbes and maintain immune balance.
- Two specific antimicrobial peptides, LjPL-3 and LjPL-2, were studied in Japanese sea bass, showing different levels of expression in various tissues after bacterial infection.
- Both peptides boosted the immune response by reducing inflammation and enhancing monocyte/macrophage activity, with LjPL-2 being particularly effective in killing bacteria, ultimately helping the fish survive infections better.
Background: Childhood obesity is a worldwide critical health concern. We aimed to clarify whether eating behaviours increased the risk of childhood obesity.
Methods: We recruited 2,049 pre-school children aged 3-6 years between 1 December 2021 and 31 January 2022 in Taizhou, China.
Incorporating heterometal and chromogenic groups into the titanium oxo cluster (TOC) nanomaterials is one of the effective strategies for the development of new high-performance photoelectrically active materials. In this Article, we report the structures and photoelectrochemical (PEC) performances of a family of TOCs, including pure [TiO(OEt)L] () and six Cd-doped clusters formulated as [HCdTiO(OEt)(L)(HO)] (; L = salicylic acid and their derivatives). The six Cd-doped clusters are isostructural, containing the same {CdTiO} core, but are protected by salicylic ligands modified with different functional groups.
View Article and Find Full Text PDFSomatosensory evoked potentials (SEPs) have been widely used to assess neurological function in clinical practice. A good understanding of the association between SEP signals and neurological function is helpful for precise diagnosis of impairment location. Previous studies on SEPs have been reported in animal models.
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- Bioassay-guided fractionation of Bacillus amyloliquefaciens W1 led to the isolation of eight acaricidal cyclodipeptides through column chromatography and HPLC.
- The identified cyclodipeptides included compounds like cyclo-(Gly-l-Phe) and cyclo-(l-Tyr-trans-4-OH-l-Pro), with significant acaricidal activities, particularly cyclo-(l-Tyr-trans-4-OH-l-Pro) being five times more effective than the standard abamectin.
- This study is the first to report the acaricidal effects of these cyclodipeptides against the pest Tetranychus urticae, indicating their potential as safe and eco-friendly biocontrol
Article Synopsis
- - In a study on the impact of tilling methods and nitrogen treatments on maize growth in the Huanghuaihai Plain, three tilling methods (conventional, rotary, and subsoiling) were tested alongside three nitrogen levels (120, 225, and 330 kg·hm).
- - Rotary tillage showed the highest ammonification, and higher nitrogen levels increased microbial and enzyme activity related to nitrogen transformation; however, subsoiling tillage outperformed the others in nitrification and denitrification activities.
- - The combination of subsoiling tillage with 225 kg·hm of nitrogen optimized soil nitrogen transformation, while using 330 kg·hm led to the highest maize yield, indicating a balance between nitrogen
Article Synopsis
- * A total of 492 out of 1397 patients were examined, classified into three types based on their Garden Index measurements, with type A showing the best healing rates and lowest necrosis incidence.
- * The results indicated significant differences in nonunion and necrosis rates among the three types, with type A patients experiencing fewer complications compared to types B and C.
Bortezomib (BTZ), a proteasome inhibitor, is the first proteasome inhibitor to be used in clinical practice. Here we investigated the mechanisms underlying acquired bortezomib resistance in hepatocellular carcinoma (HCC) cells. Using stepwise selection, we established two acquired bortezomib-resistant HCC cell lines, a bortezomib-resistant HepG2 cell line (HepG2/BTZ) and bortezomib-resistant HuH7 cell line (HuH7/BTZ).
View Article and Find Full Text PDFBackground: Imbalance in bone remodeling causes osteoporosis.
Purpose: In the present study, we identified that protocatechuic acid inhibits osteoclast differentiation and induces apoptosis in RAW264.7 murine macrophage cells.
Article Synopsis
- The Foxc2 protein is crucial for cardiovascular development, with Foxc2 null mice exhibiting severe heart defects that mirror some human congenital heart diseases.
- The study explores how Foxc2 is expressed in certain cells important for developing the aortic arch, using a conditional knockout strategy to analyze its specific roles.
- Results reveal that loss of Foxc2 in certain cell populations leads to significant heart defects, while its deletion in a different type of endothelial cell results in death from fluid accumulation rather than heart issues.
Article Synopsis
- Patients with chronic hepatitis C virus (HCV) infections face serious health risks, including liver disease and cancer.
- Researchers created a transgenic mouse model (A line mouse) that carries the HCV genome and can produce infectious viruses, mirroring the viral load found in human patients.
- This new mouse model shows specific liver conditions without severe inflammation or cancer, making it a valuable tool for studying HCV and developing new treatments.
Article Synopsis
- The ubiquitin-proteasome pathway is crucial for regulating cell death (apoptosis) and the cell cycle, with proteasome inhibitors showing promise in cancer treatment, especially in multiple myeloma.
- Some flavones, like apigenin and chrysin, are known to inhibit proteasome activity and induce apoptosis, but research on other flavones is limited.
- In a study, specific flavonoids (5,6,7-trihydroxyflavone, baicalein, and scutellarein) were tested, revealing that baicalein and scutellarein do not inhibit proteasome activity, indicating that certain hydroxy group configurations are ineffective against the
The fungal pathogen Cochliobolus carbonum (anamorph, Bipolaris zeicola) causes Northern Leaf Spot, leading to a ubiquitous and devastating foliar disease of corn in Yunnan Province, China. Asexual spores (conidia) play a major role in both epidemics and pathogenesis of Northern Leaf Spot, but the molecular mechanism of conidiation in C. carbonum has remained elusive.
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- A new lipase enzyme, lipB, from Serratia marcescens ECU1010, shows high stability in organic solvents compared to a similar enzyme, lipA.
- Researchers identified three key amino acid differences between lipB and lipA, focusing on how these affect solvent stability.
- Mutating the Gly33 residue in lipB to Asp reduced its stability in organic solvents, indicating that Gly33 is crucial for maintaining this stability.
A simple capillary array IEF device was developed for high resolution and micropreparative separation of trace amounts of proteins. Based on quasi-chip-scale manufacturing, the specific capillaries (600 μm i.d.
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- Hemoglobin A1c (HbA1c) is an important marker used to check for diabetes, but a new form called GSS-HbA1c hasn't been studied much yet.
- Researchers used special techniques to separate and analyze different types of hemoglobin in blood samples to understand GSS-HbA1c better.
- They found that GSS-HbA1c affects the measurement of HbA1c levels in blood, which is important for diagnosing diabetes correctly.
Article Synopsis
- Baicalin and scutellarin are key flavonoids found in Chinese herbs, Scutellaria baicalensis and Erigeron breviscapus, known for their antitumor effects.
- The exact mechanisms behind their action are still unclear, but previous research indicates some flavonoids inhibit proteasome activities and promote apoptosis in cancer cells.
- Recent studies showed that baicalin and scutellarin specifically inhibit chymotrypsin-like activity of the proteasome, without affecting other enzymatic activities, suggesting a targeted action against tumor cells.
Article Synopsis
- * Researchers created transgenic mice with a mutation in the Rb protein that makes it resistant to phosphorylation, leading to liver tumors (adenomas) appearing in about half the mice by 15 months of age.
- * In these mutant mice, the gene c-Myc was consistently overexpressed, along with several of its target genes, which suggests that continuous activation of these genes contributes to liver tumor development over time.
Article Synopsis
- Momordica charantia (MC), a traditional Asian food and medicine, contains a polypeptide called Polypeptide-P that has shown potential in lowering blood sugar levels in diabetes patients.
- Researchers successfully cloned the gene for Polypeptide-P from MC seeds using advanced techniques, resulting in a complete sequence of 498 base pairs.
- The cloned gene may offer insights into how Polypeptide-P is regulated in MC and could aid in developing new MC varieties with high levels of this beneficial compound, potentially supporting agricultural improvements.
The ubiquitin-proteasome pathway has an important role in regulating apoptosis and the cell cycle. The function of proteasomes is mediated by three main catalytic activities: (1) chymotrypsin-like (CT-L), (2) trypsin-like (T-L), and (3) peptidylglutamyl peptide hydrolyzing (PGPH). Recently, proteasome inhibitors have been revealed to have an antitumor effect, and have been used to treat cancers such as multiple myeloma.
View Article and Find Full Text PDFLeydig cell hypoplasia (LCH) is a rare form of male pseudohermaphroditism caused by inactivating mutations in the luteinizing hormone receptor gene (LHCGR). The majority of LHCGR mutations are located in the coding sequence, resulting in impairment of either LH/CG binding or signal transduction. We report a Chinese family with two siblings (46, XY and 46, XX) carrying a missense mutation (c.
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