Accelerated arsenic decontamination using graphene oxide-supported metal-organic framework nanoconfined membrane for sustainable performance.

Developing highly efficient bimetallic metal-organic frameworks (MOFs) as catalysts for Fenton-like reactions holds significant promise for decontamination processes. Although MOFs with excellent decontamination capabilities are achievable, ensuring their long-term stability, especially in the organoarsenic harmless treatment, remains a formidable challenge. Herein, we proposed a unique nanoconfinement strategy using graphene oxide (GO)-supported Prussian blue analogs (PBA) as catalytic membrane, which modulated the peroxymonosulfate (PMS) activation in p-arsanilic acid (p-ASA) degradation from traditional radical pathways to a synergy of both radical and non-radical pathways.

A tunable and reversible thermo-inducible bio-switch for streptomycetes.

Programmable control of bacterial gene expression holds great significance for both applied and academic research. This is particularly true for Streptomyces, a genus of Gram-positive bacteria and major producers of prodigious natural products. Despite that a few inducible regulatory systems have been developed for use in Streptomyces, there is an increasing pursuit to augment the toolkit of high-performance induction systems.

regulates the proliferation and differentiation of neural stem/progenitor cells.

Background: MicroRNAs (miRNAs) have emerged as an essential regulator of the cell fate commitment of neural stem/progenitor cells (NPCs), although the impacts of certain miRNAs on NPCs remain vague. The aim of this study is to investigate the regulatory effects of on the cell fate commitment of NPCs.

Methods: We investigated the impact of on the proliferation and differentiation capacities of primary NPCs by manipulating the expression of using specific mimics and inhibitors.

Gut Microbiota as Mediator and Moderator Between Hepatitis B Virus and Hepatocellular Carcinoma: A Prospective Study.

Background: The impact of gut microbiome on hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) is unclear. We aimed to evaluate the potential correlation between gut microbiome and HBV-related HCC and introduced novel machine learning (ML) signatures based on gut microbe to predict the risk of HCC.

Materials And Methods: A total of 640 patients with chronic liver diseases or HCC were prospectively recruited between 2019 and 2022.

The trigger mechanisms and the gene regulatory pathways of organic acid secretion during the vanadium-titanium magnetite tailing bioleaching.

The long-term mining of vanadium-titanium (V-Ti) magnetite has generated a large accumulation of tailings, which can lead to metal pollution via microbial bioleaching. Current research has focused on the bioleaching of minerals, and a few studies have explored microbial responses to metals only through limited metabolite concentrations. However, the trigger mechanisms of metal release during the V-Ti magnetite tailing bioleaching and key gene regulatory pathways for organic acid metabolism are still unclear.

Continuous Evolution of Protein through T7 RNA Polymerase-Guided Base Editing in .

targeted mutagenesis technologies are the basis for the continuous directed evolution of specific proteins. Here, an efficient mutagenesis system (CgMutaT7) for continuous evolution of the targeted gene in was developed. First, cytosine deaminase and uracil-DNA glycosylase inhibitor were sequentially fused to T7 RNA polymerase using flexible linkers to build the CgMutaT7 system, which introduces mutations in targeted regions controlled by the T7 promoter.

Dynamic susceptibility contrast perfusion MRI helps in differentiating double-expressor from non-double-expressor subtypes in primary central nervous system lymphoma.

Purpose: In the 2016 WHO Classification of Lymphoid Tissue Neoplasms, co-expression of MYC and BCL2 is newly designated as double expressor lymphoma. Patients with primary central nervous system lymphoma with double expressor (DE-PCNSL) have been reported to have a higher risk of recurrence and a worse prognosis than those with PCNSL without double expressor (non-DE-PCNSL). The aim of this study was to determine whether DE-PCNSL has characteristic clinical and MR imaging features compared to non-DE-PCNSL.

quantitative assessment of proximal femoral cortical bone microstructure using double-echo ultrashort echo time magnetic resonance imaging.

Background: Quantitative assessment of cortical bone microstructure is crucial for the evaluation of osteoporosis, yet current clinical methods such as dual-energy X-ray absorptiometry (DXA) have many limitations. The quantitative assessment without radiation can be achieved by ultrashort echo time (UTE) magnetic resonance imaging (MRI), where double-echo UTE has high clinical feasibility. However, related studies have mainly focused on distal extremities, and there is a lack of studies on the proximal femur.

A multispatial information representation model emphasizing key brain regions for Alzheimer's disease diagnosis with structural magnetic resonance imaging.

Background: Structural magnetic resonance imaging (sMRI) can reflect structural abnormalities of the brain. Due to its high tissue contrast and spatial resolution, it is considered as an MRI sequence in diagnostic tasks related to Alzheimer's disease (AD). Thus far, most studies based on sMRI have only focused on pathological changes in disease-related brain regions in Euclidean space, ignoring the association and interaction between brain regions represented in non-Euclidean space.

Diffusion-derived vessel density (DDVD) for penumbra delineation in brain acute ischemic stroke: initial proof-of-concept results using single NEX DWI.

Neuroimaging is a cornerstone in the diagnosis and treatment decision-making for brain acute ischemic stroke. A rapid and accurate diagnosis is the key, specifically for time-critical reperfusion therapies. Successful reperfusion of salvageable penumbra can reduce the extent of ischemic stroke and thus improve clinical outcomes, whereas reperfusion of irreversibly affected brain tissue is thought to be futile and may result in harm due to the risk of hemorrhagic transformation.

Feasibility study of low-dose computed tomography (CT) technology for maxillofacial bone three-dimensional (3D) printing in skeletal class III malocclusion.

Background: Skeletal class III malocclusion is among the most common dental and maxillofacial malformations. Three-dimensional (3D) printing technology has become widely applied in orthopaedics. The data source for 3D printing of maxillofacial bones is computed tomography (CT).

Diagnosis of liver hemangioma using magnetic resonance diffusion-derived vessel density (DDVD) pixelwise map: a preliminary descriptive study.

Background: Liver hemangiomas (HGs) are characterized by cavernous venous spaces delineated by a lining of vascular endothelial cells and interspersed with connective tissue septa. Typically, a liver HG has higher apparent diffusion coefficient (ADC) and T2 values than those of hepatocellular carcinomas (HCCs) and liver metastases, and lower ADC and T2 values than those of liver simple cysts. However, a portion of HGs shows ADC and T2 overlapping with those of HCC, liver metastasis, and simple cyst.

Improved T-shaped quartz tuning fork with isosceles-trapezoidal grooves optimized for quartz-enhanced photoacoustic spectroscopy.

The quartz tuning fork (QTF) being the acoustic-electrical conversion element for quartz-enhanced photoacoustic spectroscopy (QEPAS) system directly affects the detection sensitivity. However, the low electromechanical conversion efficiency characteristic of standard QTF limits the further enhancement of the system. Therefore, the optimized design for QTF is becoming an important approach to improve the performance of QEPAS.

[Effect and related mechanism of acetate in alleviating acute kidney injury in septic rats through G-protein coupled receptor 43].

Objective: To explore the protective effect and mechanism of acetate on sepsis-induced acute kidney injury (AKI) in rats.

Methods: Male Sprague-Dawley (SD) rats were divided into sham operation group (Sham group), sepsis group caused by cecal ligation and puncture (CLP group), and acetate pretreatment group [NaA group, gavage sodium acetate (NaA) 300 mg/kg twice a day for 7 consecutive days before CLP] using a random number table method, with 7 rats in each group. The blood was taken from the main abdominal artery 24 hours after modeling, and renal tissue was collected from the rats.

Prostatitis, benign prostatic hyperplasia, and prostate cancer: a bidirectional Mendelian randomization study and clinical implications for these patients' populations.

Background: No authoritative books or guidelines are currently available for revealing the interrelationships of prostatitis, benign prostatic hyperplasia (BPH), and prostate cancer (PCa). Moreover, no consensus on this issue has been reached among previously published epidemiological studies or meta-analyses.

Purpose: We first took advantage of Mendelian randomization to clarify this issue and provide clinical implications for these patients' populations.

Apoptotic body based biomimetic hybrid nanovesicles to attenuate cytokine storms for sepsis treatment.

Sepsis is a severe immune response to pathogens that is associated with high mortality rate and a paucity of efficacious treatment options. It is characterized by the hyperactivation of macrophages and the occurrence of cytokine storms. Given the anti-inflammatory properties of M2 macrophages and their derived apoptotic bodies (AB), as well as the specific uptake of these by macrophages, a novel approach was employed to combine AB with artificial liposomes to create apoptotic body based biomimetic hybrid nanovesicles (L-AB).

A novel major QTL underlying grain copper concentration in common wheat (Triticum aestivum L.).

Grain copper (Cu) concentrations represent a qualitative trait mainly controlled by genetic factors, which may differ between wheat varieties from the Sichuan Basin of China and other areas. However, the differences are poorly understood. Here, we investigated the grain Cu concentration in a remaining heterozygous line population derived from a multiparental recombinant inbred line.

The correlation between protein energy wasting and the incidence of main adverse cardiovascular events in adult maintenance hemodialysis patients: a single-center retrospective cohort study.

Background: Protein energy wasting (PEW) is prevalent in adult maintenance hemodialysis (MHD) patients. Concurrently, cardiovascular diseases (CVD) remain a leading cause of mortality in MHD patients. However, the relationship between PEW and CVD in MHD patients remains unclear.

CD34+ orbital fibroblasts contribute to the pathogenesis of thyroid eye disease via miR-182-5p.

Context: CD34+ orbital fibroblasts (OFs) play a pathogenic role in thyroid eye disease (TED). Several micro (mi)RNAs have been shown to promote TED progression.

Objective: This study aims to explore the regulatory effect of miRNAs on CD34+ OFs, to find potential therapeutic target.

Renal function and risk of gestational diabetes mellitus: the potential mediating role of carnitine metabolites.

Context: Renal function may play a crucial role in the development of gestational diabetes mellitus (GDM). However, prospective studies on this topic are scarce and the mechanisms remain unclear.

Objective: To assess the associations of early-pregnancy renal function with GDM and the mediating role of carnitine metabolites.

Comparative effectiveness totally endoscopic thyroidectomy via completely submental tri-hole approach and transoral endoscopic thyroidectomy without insufflation.

Objective: This study aims to evaluate the therapeutic effectiveness of totally endoscopic thyroidectomy via the completely submental tri-hole approach and transoral endoscopic thyroidectomy without insufflation.

Methods: A total of 60 patients with thyroid tumors who were admitted to Panyu College Affiliated Hospital from August 2022 to August 2023 were collected in this study. The patients were divided into two groups, the transoral endoscopic thyroidectomy group (20 cases) and the totally endoscopic thyroidectomy via the completely submental tri-hole approach group (40 cases).

Enhanced Reader Confidence and Differentiation of Calcification from Cerebral Microbleed Diagnosis Using QSM Relative to SWI.

Purpose: Accurate detection of cerebral microbleeds (CMBs) is important for detection of multiple conditions. However, CMBs can be challenging to identify on MR images, especially for distinguishing CMBs from the mimic of calcification. We performed a comparative reader study to assess the diagnostic performance of two primary MR sequences for differentiating CMBs from calcification.

Supine bicycle stress echocardiography at low altitude for identification of susceptibility to acute mountain sickness.

Background: Exposure to high altitude may unpredictably lead to acute mountain sickness (AMS). The purpose of this study was to identify the predictors of AMS at low altitude by exercise stress echocardiography (ESE).

Methods: A total of 40 healthy adults were enrolled and underwent comprehensive supine bicycle ESE at low altitude, including pulmonary vascular resistance (PVR), right ventricular (RV) area index at the end of diastole (RVEDAi), B-lines, and inferior vena cava (IVC) diameter.

Regulating the Atomic Active Center by Covalent Organic Framework-Derived Photothermal Nanozyme to Arm Self-Gelling Powder for Bacterial Wound Healing.

Creating simple methods to produce antioxidant nanozymes with clear structure-activity relationships, particularly aiming to improve disinfection and create practical drug formulations for bacterial wound healing, remains a crucial challenge. Herein, we synthesized iron-loaded covalent organic framework nanospheres, which were then controllably transformed into a carbon-based nanozyme with both iron single atoms and iron clusters through simple pyrolysis. We discovered that the gradual growth of iron clusters significantly boosted the nanozyme's adsorption onto the substrate and electron transfer, greatly influencing its activity.