Codonopsis pilosula Polysaccharides Alleviate Aβ -Induced PC12 Cells Energy Dysmetabolism via CD38/NAD+ Signaling Pathway.

Background: Alzheimer's disease (AD) is the most common type of dementia and has a complex pathogenesis with no effective treatment. Energy metabolism disorders, as an early pathological event of AD,have attracted attention as a promising area of AD research. Codonopsis pilosula Polysaccharides are the main effective components of Codonopsis pilosula, which have been demonstrated to regulate energy metabolism.

Impact of Social Needs Navigation on Utilization Among High Utilizers in a Large Integrated Health System: a Quasi-experimental Study.

Background: Programs addressing social determinants of health for high-utilizing patients are gaining interest among health systems as an avenue to promote health and decrease utilization.

Objective: To evaluate impacts of a social needs screening and navigation program for adult predicted high utilizers on total medical visit utilization.

Design: A prospective, quasi-experimental study using an intent-to-treat propensity-weighted difference-in-differences approach.

Improving antibiotic stewardship: a stepped-wedge cluster randomized trial.

Objectives: Antibiotic stewardship is key to optimizing patient outcomes and affordable care. The study objective was to examine the effect of provider education and clinical decision support (CDS) on antibiotic prescribing for acute sinusitis among providers of varying experience.

Study Design: A stepped-wedge cluster randomized intervention to evaluate antibiotic use for acute sinusitis encounters at 126 Kaiser Permanente Southern California clinics between September 2014 and April 2015.