The association of diffusion tensor MRI measures of normal appearing white matter and cognition.

Objective: Median and peak height of fractional anisotropy (FA) and mean diffusivity (MD) are diffusion tensor imaging (DTI) markers used to quantify white matter microstructure changes. We examine the association of DTI histogram-derived measures in global normal appearing white matter (NAWM) and cognitive decline in patients with normal cognition and cognitive impairment no dementia from a memory clinic in Singapore.

Methods: A total of 252 patients (mean age: 71.

Association between nutrition and cognition in a multi-ethnic cohort from Singapore.

Background: Nutrition, a modifiable risk factor, presents a low-cost prevention strategy to reduce the burden of cognitive impairment and dementia. However, studies examining the effects of dietary patterns on cognition are lacking in multi-ethnic Asian populations. We investigate the association between diet quality, measured with the Alternative Healthy Eating Index (AHEI)-2010, and cognitive impairment in middle-aged and older adults of different ethnicities (Chinese, Malay, Indian) in Singapore.

Handgrip Strength and Cognitive Performance in a Multiethnic Cohort in Singapore.

Background: Handgrip strength (HGS) is an important marker of frailty but there is limited research on lifestyle and vascular determinants of HGS and its relationship with cognitive impairment.

Objective: To identify determinants of HGS and the association of HGS with cognitive impairment in a multiethnic cohort from Singapore.

Methods: This study (n = 2,109, median [Q1, Q3] age: 53 [48, 60] years, 59.