Occurrence of microplastics and distinct plastisphere in aquatic environments of metal mining areas in South China.

Microplastic pollution is a growing global environmental concern, significantly impacting aquatic ecosystems. In metal mining regions, acid mine drainage (AMD) can exacerbate the issue as microplastics may carry heavy metals, heightening the risks to both human health and ecosystems. AMD can also form a distinct plastisphere further influencing the behavior and distribution of heavy metals.

Electrolyte engineering via non-fluorinated solvent for high-performance lithium metal batteries.

Lithium metal batteries (LMBs) employing high-voltage cathode present a promising pathway toward high-energy-density energy storage systems. However, critical challenges have hindered their practical application, including lithium dendrite proliferation, unstable solid-electrolyte interphase (SEI), and limited oxidative stability of conventional 1,2-dimethoxyethane (DME)-based electrolytes. Herein, we rationally design a siloxane-based electrolyte system featuring enhanced oxidative stability through solvent molecular engineering.

Influence of COVID-19 Vaccination on Treatment-Related Adverse Events and Oncologic Outcomes of Nonmetastatic Nasopharyngeal Carcinoma.

Background: The influence of COVID-19 vaccination before chemoradiotherapy on nonmetastatic nasopharyngeal carcinoma (NPC) is not known.

Methods: Propensity score matching was used to minimize potential selection bias between groups. Primary endpoints were treatment-related adverse events (TRAEs).

Tunable Synthesis of 2D Bismuth Oxyhydroxide and Oxysulfide from Solid-Liquid Interfacial Reaction for High Performance Optoelectronic Gas Sensing.

The self-limiting Cabrera-Mott oxidation reaction on metal surfaces provides an effective pathway for synthesizing atomically thin 2D metal oxide. Inspired by this reaction, it is proposed that solid bismuth metals can react with dissolved oxygen and water molecules in an aqueous environment, forming an ultrathin oxyhydroxide layer on their surfaces. The lattice mismatch between the surface oxyhydroxide layer and the underlying pure metal enables the mechanical exfoliation of detached 2D oxyhydroxide nanosheets.

Boron-Doped Graphene as Anion-Trapping Reagent in Poly(ethylene oxide)-Based Solid-State Electrolyte.

Although many protocols have been developed to enhance the ionic conductivity and lithium-ion transference numbers of the solid polymer electrolyte, it is still challenging to improve them simultaneously. Herein, we design and prepare boron-doped graphene (BG) as an anion trapper and blend it within a poly(ethylene oxide) (PEO)-based electrolyte. The well-dispersed BG sheets can reduce the crystallinity of PEO and afford numerous Lewis acid sites to effectively accelerate the dissociation of the lithium salt and trap the anions.

Construction of biomass-derived magnetic-recyclable FeNi-LDO@CS to activate persulfate for simultaneous degradation of cationic and anionic dyes: Discrepancy, mechanism and toxicity analysis.

In this study, layered chitosan-based magnetic nickel ferrite NiFeO/chitosan (CS-LDO) composites were synthesized. The results show that under optimal conditions, 98 % of methylene blue (MB) and 92 % of xylenol orange (XO) can be simultaneously degraded within 120 min in the CS-LDO/persulfate (PS) system, and the removal rates of total organic carbon (TOC) and chemical oxygen demand (COD) can reach 67.32 % and 74.

Interactions among dyadic coping, self-efficacy, and negative emotions in Chinese parents of children with leukemia.

Background And Aim: The prevalence of childhood leukemia in China has been on the rise, imposing significant psychological burden on parents. Currently, few studies have explored the dyadic coping status of parents of children with leukemia and its influencing factors. This study aimed to investigate the associations among dyadic coping, self-efficacy, anxiety and depression in parents of children with leukemia.

Millennial-scale climate variability of the Asian summer monsoon over the last 690,000 years: insights from cave records.

The Asian summer monsoon (ASM) is an important component of the global climate system. Cave oxygen isotope (δO) records from the region have well characterized the ASM millennial-scale climate variability (MCV) over the last 640 ka, with especially detailed insights for the most recent 60 ka, but little is known about ASM variability beyond the U-Th dating limit of ∼640 ka. Furthermore, questions remain regarding the climatic significance of millennial-scale ASM variability recorded among various climate archives, particularly in the context of the "orbital-scale paradox".

Polyhalogenated carbazoles in the environment: Analysis, origins, occurrence, and toxicity.

Polyhalogenated carbazoles are a class of emerging organic compounds characterized by the substitution of one to eight hydrogen atoms in the carbazole structure with halogen atom(s). Polyhalogenated carbazoles originate from natural and anthropogenic sources and are widely distributed in the environment. They are persistent in the environment and present a range of toxic effects, notably dioxin-like activity.

Identification of AK4 and RHOC as potential oncogenes addicted by adult T cell leukemia.

Adult T cell leukemia (ATL) is a highly aggressive T cell malignancy characterized by human T cell leukemia virus type 1 (HTLV-1) infection. ATL has a very poor prognosis and lacks satisfactory treatments; therefore, it is critical to identify potential targets in ATL cells in order to develop effective targeted therapeutics. Here, we report the identification of two oncogenes, AK4 and RHOC, as target genes of miR-455-3p, a tumor-suppressive microRNA in ATL patients.

Chemocatalytic Cell Tagging Platform for Recording Cell-Cell Interactions via Engineered Palladium-Based Artificial Metalloenzymes.

Proximity labeling platforms (PLPs) have become a powerful tool for studying spatial cell-cell interactions (CCIs) in living organisms. However, their effectiveness often relies on membranal catalytic modules of bait cells, such as natural enzymes or small-molecule photocatalysts, which are typically constrained by complex genetic modifications or the limited applicability of visible light. Here, we present a novel chemocatalytic approach, ArM-Tag, which utilizes an engineered artificial metalloenzyme (ArM) for cell surface-localized tagging.

Disease burden of trachea, bronchus and lung cancer 1990-2021 and global trends projected to 2035.

Tracheal, bronchial, and lung cancer (TBL) is among the most common malignancies worldwide, with persistently high incidence and mortality rates, posing a significant threat to public health. However, existing studies on TBL disease burden are often limited to specific regions or short-term trends, lacking systematic and predictive analyses. This study comprehensively evaluated the global, regional, and national burden of TBL across 204 countries and territories from 1990 to 2021, utilizing predictive models to estimate trends from 2022 to 2035.

Prediction of Weaning Outcomes in Mechanically Ventilated Patients Using Diaphragmatic Excursion With Tissue Doppler Imaging Variables of the Diaphragm.

Diaphragmatic excursion is a crucial predictor of extubation outcomes in subjects on mechanical ventilation. However, its measurement can be influenced by various factors, which leads to inconsistent optimal thresholds and accuracy. Tissue Doppler imaging variables of the diaphragm have been established as reliable indicators for predicting extubation outcomes.

Efficacy of Different Acupuncture Techniques for Pain and Dysfunction in Patients with Knee Osteoarthritis: A Randomized Controlled Trial.

Introduction: Various acupuncture techniques are widely applied in clinics for pain control and dysfunction relief in patients with knee osteoarthritis (KOA). The purpose of this trial was to investigate whether the different acupuncture techniques were more effective in treating joint pain and dysfunction than were sham acupuncture or drug treatment in patients with KOA and to determine the differences in efficacy among them.

Methods: In this multi-center, single-blind, randomized, controlled trial, participants were randomly assigned to the manual acupuncture (MA), electroacupuncture (EA), warm-needling acupuncture (WA), mild moxibustion (MM), sham acupuncture (SA), or drug treatment (Celebrex) groups.

Investigation and study on the epidemiology of gestational diabetes mellitus in Guizhou.

Background: Gestational diabetes mellitus (GDM) is a growing public health concern, particularly in regions with diverse ethnic populations. Understanding the incidence and risk factors of GDM is crucial for early prevention and management, especially in underrepresented areas like Guizhou Province, China, where geographic and ethnic diversity may influence the disease's prevalence and risk profiles.

Aim: To investigate the incidence of GDM and identify its associated risk and protective factors among different ethnic groups in Guizhou Province, providing essential data for early prevention strategies.

CircFUNDC1 interacts with CDK9 to promote mitophagy in nucleus pulposus cells under oxidative stress and ameliorates intervertebral disc degeneration.

Intervertebral disc degeneration (IVDD) is a leading cause of low back pain, with limited effective treatments due to an incomplete understanding of disease mechanisms. In this study, we report that circFUNDC1, a nuclear circular RNA, is markedly downregulated in nucleus pulposus cells (NPCs) from patients with end-stage IVDD. CircFUNDC1 is derived from the gene encoding the FUN14 domain-containing 1 (FUNDC1) protein, which is essential for mitophagy and cell survival.

A Multidisciplinary-Based and Bundle Intervention for Controlling Carbapenem-Resistant Organisms in Neurosurgery.

Purpose: Carbapenem-resistant organisms (CROs) have been listed as the primary risk resistance bacteria due to their high detection rates and extensive drug resistance. Research on the effectiveness of CRO intervention programs in secondary hospitals is limited. This study aims to observe the effect of multidisciplinary-based and bundle interventions under PDCA (plan-do-check-act) cycle management on the control of CROs in neurosurgery.

Association between hyperuricemia and dietary retinol intake in Southwest China: a cross-sectional study based on CHNS database.

Background: Hyperuricemia is increasingly common in Southwestern China and poses significant health risks, including gout and cardiovascular disease. Retinol intake has been hypothesized to affect uric acid levels, but this relationship remains unclear.

Methods: Data from 4,658 participants in the China Health and Nutrition Survey (CHNS) from 1991 to 2018 were analyzed.

Quality risk management for microbial control in membrane-based water for injection production using fuzzy-failure mode and effects analysis.

Microbial proliferation presents a significant challenge in membrane-based water for injection (WFI) production, particularly in systems with storage and ambient distribution, commonly refered to as cold WFI production. A comprehensive microbial risk assessment of membrane-based WFI systems was performed by employing Fuzzy-Failure Mode and Effects Analysis (Fuzzy-FMEA) to evaluate the potential microbial risks. Failure modes were identified and prioritized based on the Risk Priority Number (RPN), with appropriate preventive measures recommended to control failure modes that could increase the microbial load and mitigate their impact.

Synchronicity of pyramidal neurones in the neocortex dominates isoflurane-induced burst suppression in mice.

Background: Anaesthesia-induced burst suppression signifies profound cerebral inactivation. Although considerable efforts have been directed towards elucidating the electroencephalographic manifestation of burst suppression, the neuronal underpinnings that give rise to isoflurane-induced burst suppression are unclear.

Methods: Electroencephalography combined with micro-endoscopic calcium imaging was used to investigate the neural mechanisms of isoflurane-induced burst suppression.

Novel genetic insight for psoriasis: integrative genome-wide analyses in 863 080 individuals and proteome-wide Mendelian randomization.

Psoriasis affects a significant proportion of the worldwide population and causes an extremely heavy psychological and physical burden. The existing therapeutic schemes have many deficiencies such as limited efficacies and various side effects. Therefore, novel ways of treating psoriasis are urgently needed.

Lumbar temperature change after acupuncture or moxibustion at Weizhong (BL40) or Chize (LU5) in healthy adults: A randomized controlled trial.

Background: There is a gap in understanding the effects of different acupoints and treatment methods (acupuncture and moxibustion) on microcirculatory changes in the lumbar region.

Objective: This study aimed to assess the thermal effects of acupuncture at Weizhong (BL40), with acupuncture at Chize (LU5) and moxibustion at both acupoints as control interventions.

Design, Setting, Participants And Interventions: In this randomized controlled trial, 140 healthy participants were equally divided into four groups: acupuncture at BL40 (Acu-BL40), acupuncture at LU5 (Acu-LU5), moxibustion at BL40 (Mox-BL40) and moxibustion at LU5 (Mox-LU5).

Response of Plant Leaf Traits to Environmental Factors in Climax Communities at Varying Latitudes in Karst Regions.

Exploring the changes in plant functional traits and their relationship with the environment in karst climax communities across different latitudes can enhance our understanding of how these communities respond to environmental gradients. In this study, we focus on climax karst climax plant communities in Guizhou Province, China. We selected three sample sites located at varying latitudes and analyzed the variations in functional traits of the plant communities at these latitudes.