The First Compound Heterozygosity for Two Different α-Thalassemia Determinants Causes Hb Bart's Hydrops Fetalis in a Chinese Family.

In southern China, α-thalassemia is the most prevalent hereditary monogenic disorder, and deletion variants are the predominant form. Conventional thalassemia diagnosis techniques are numerous, however they are all limited in their ability to detect rare deletions. Here, we discuss a family who sought genetic counseling during their fourth pregnancy after experiencing Hb Bart's hydrops fetalis in two of their previous pregnancies.

Altering Carotene Hydroxylase Activity of DcCYP97C1 Affects Carotenoid Flux and Changes Taproot Colour in Carrot.

CYP97C1 as a haem-containing cytochrome P450 hydroxylase (P450-type) is important for carotene hydroxylation and xanthophyll biosynthesis. Research about this type of hydroxylase was mainly reported in several model plant species which have no specialized tissues accumulating massive carotenoids. The function of CYP97C1 in the horticultural plant, like carrots, was not fully studied.

Co-metabolic Biotransformation of Bisphenol AF by a Bisphenol A-Growing Bacterial Enrichment Culture.

The fluorinated bisphenol A (2,2-bis[4-hydroxyphenyl]propane, BPA) substitute bisphenol AF (BPAF) could be more persistent and toxic than BPA, but little is known about its environmental fate. In this study, we established a co-metabolic BPAF-degrading bacterial enrichment culture with BPA as the growth substrate. BPAF degradation by the enrichment culture was dependent on BPA, and BPAF could be eliminated to below the detection limit with successive additions of BPA.

Dipole Modulation Engineering Enhances Structural Order of PEDOT:PSS for Efficient and Stable InP-Based QLEDs.

Indium phosphide (InP)-based quantum dot light-emitting diodes (QLEDs) are promising for future lighting and display applications due to their high color purity and brightness. However, their efficiency and stability are often limited by the disordered structure of the widely used poly(3,4-ethylenedioxythiophene):polystyrenesulfonate (PEDOT:PSS), which impairs charge transport. Herein, we present a strategy to enhance the performance of InP-based QLEDs by modifying PEDOT:PSS through interfacial dipole modulation using molybdenum oxide (MoO) nanoparticles.

O-GlcNAcylation of progranulin promotes hepatocellular carcinoma proliferation.

Progranulin (PGRN) is overexpressed and implicated in hepatocellular carcinoma (HCC) development; however, its post-translational modifications and regulatory mechanisms in HCC remain largely unexplored. Here, the expression levels of PGRN, OGT, and O-GlcNAcylation were found to be elevated in both HCC samples and cell lines. LC-MS/MS analysis and immunoprecipitation revealed that PGRN underwent O-linked N-acetylglucosamine (O-GlcNAc) modification at threonine 272 (Thr272).

StCPP3 interacts with type III secretion protein HrpB7 and negatively regulates plant resistance against Ralstonia solanacearum.

Cysteine-rich polycomb-like proteins (CPP) are crucial in regulating plant stress responses while the underlying functions of CPP involving plant- Ralstonia solanacaearum interaction remain unknown. Here, we showed the expression patterns of a potato CPP gene (StCPP3) under phytohormone treatments, biotic and abiotic stressed and its role in resistance against of R. solanacaearum infection by loss- and gain-of-function approaches.

The Impact of Remote Symptom Management on Exercise Adherence after Video-assisted Thoracic Surgery (VATS) for Lung Cancer in a Tertiary Hospital in China: A Prospective, Randomized, Controlled Study Protocol.

Background: Regular pulmonary rehabilitation exercises are crucial for patients with lung cancer after surgery. However, poor adherence to outpatient exercises is difficult to address due to inadequate supervision. The integration of remote symptom management via electronic patient-reported outcomes (ePRO) offers a potential solution to improve adherence by enabling more effective monitoring and intervention.

Real-world Use of AlloDerm Acellular Dermal Matrix in Head and Neck Procedures in the United States.

Background: Real-world literature evaluating the use of AlloDerm SELECT Regenerative Tissue Matrix in head- and neck-related procedures is limited. To inform patient care decisions, this study evaluated healthcare resource utilization (HCRU) in US adults undergoing head- and neck-related procedures using AlloDerm.

Methods: A retrospective claims analysis was conducted using MarketScan Commercial and Medicare Supplemental Databases (study period: October 1, 2015, to March 31, 2022; index period: November 1, 2015, to March 1, 2022).

Recent advances in nanomaterial-enabled chemiresistive hydrogen sensors.

With the growing adoption of hydrogen energy and the rapid advancement of Internet of Things (IoT) technologies, there is an increasing demand for high-performance hydrogen gas (H) sensors. Among various sensor types, chemiresistive H sensors have emerged as particularly promising due to their excellent sensitivity, fast response times, cost-effectiveness, and portability. This review comprehensively examines the recent progress in chemiresistive H sensors, focusing on developments over the past five years in nanostructured materials such as metals, metal oxide semiconductors, and emerging alternatives.

Proteomic analysis of plasma total exosomes and placenta-derived exosomes in patients with gestational diabetes mellitus in the first and second trimesters.

Gestational diabetes mellitus (GDM) is the first spontaneous hyperglycemia during pregnancy. Early diagnosis and intervention are important for the management of the disease. This study compared and analyzed the proteins of total plasma exosomes (T-EXO) and placental-derived exosomes (PLAP-EXO) in pregnant women who subsequently developed GDM (12-16 weeks), GDM patients (24-28 weeks) and their corresponding controls to investigate the pathogenesis and biomarkers of GDM associated with exosomes.

Intelligence data acquisition based on embedded system in Chinese cuisine cooker (CCICR V1.0).

The Chinese cooking process, intricate and diverse, encompasses a wide range of dishes, generating substantial data that often poses significant challenges for automation. To address these challenges, this paper introduces a versatile, highly reliable, user-friendly, and intelligent data recorder specifically designed for Chinese cuisine-the Chinese Cuisine Intelligent Cooker Recorder-V1.0 (CCICR-V1.

Effect of Preadolescents' Obesity on Inhibitory Control During Stop-Signal Task: A Functional EEG Network Study.

. Until now, limited knowledge remains regarding the association among childhood obesity, cognitive behavior, and brain networks. Utilizing a publicly available dataset, we aimed to investigate the relationships between childhood obesity and functional networks during the stop-signal task.

N4BP3 facilitates NOD2-MAPK/NF-κB pathway in inflammatory bowel disease through mediating K63-linked RIPK2 ubiquitination.

The NOD2 signaling pathway, which plays an important role in the mechanisms of inflammatory bowel disease (IBD) development, has been closely associated with ubiquitination. It was revealed in this study that NOD2 receptor activation could obviously affect the expression of 19 ubiquitination-related genes, with N4BP3 being the most prominently expressed and upregulated. In addition, N4BP3 knockdown was found to reduce the mRNA levels of MDP-induced inflammatory factors, while N4BP3 overexpression elevated their mRNA levels as well as the levels of phospho-ERK1/2, phospho-JNK, phospho-P38 and phospho-NF-κB P65 proteins.

Serum ferritin is a risk factor for pulmonary dysfunction in young patients with transfusion-dependent thalassemia.

Research into the pulmonary function of patients with transfusion-dependent thalassemia (TDT) is limited, with existing studies presenting conflicting results. We carried out a retrospective study involving 140 patients with TDT. The mean patient age was 8.

XPS investigation of the SEI formed on LGPS and LAGP with metallic lithium.

X-ray photoelectron spectroscopy (XPS) techniques have proven to be powerful tools for the characterisation of the solid electrolyte interphase (SEI) formed between the anode and solid electrolyte (SE) in solid-state batteries. XPS offers access to time and operational condition-resolved information on the SEI's chemical composition in the absence of destructive sample preparation. Here we present a Virtual Electrode Plating XPS (VEP-XPS) investigation of the composition and stability of the SEI formed between lithium metal and two different solid electrolytes: LiGePS (LGPS) and LiAlGe(PO) (LAGP).