AMPK activation alleviated dextran sulfate sodium-induced colitis by inhibiting ferroptosis.

Objectives: Ferroptosis is a newly discovered cell death mode that has been confirmed to occur in the intestinal epithelial cells in ulcerative colitis (UC). In this study we aimed to elucidate the mechanism of ferroptosis and its association with adenosine monophosphate-activated protein kinase (AMPK) in UC.

Methods: Gene expression profiles of colonic mucosa (GSE87473) were downloaded.