Clear cell renal cell carcinoma (ccRCC) characterised by its diversity and a tendency to defy standard therapeutic approaches. Amidst the advent of immunotherapy, it has become imperative to pinpoint prognostic indicators of the tumour microenvironment (TME) influence the efficacy of treatments. Employing single-cell RNA sequencing (scRNA-seq), this research delved into the diverse landscape of ccRCC, uncovering its complex underpinnings and pinpointing molecular avenues for therapeutic intervention.
View Article and Find Full Text PDFBackground: UCHL5 was initially recognized as a multifunctional molecule. While recent research has highlighted its involvement in tumor malignant biological behaviors, its specific role in promoting tumor cell apoptosis has drawn particular attention. However, the precise relationship between UCHL5 and various tumor types, as well as its influence within the immune microenvironment, remains unclear.
View Article and Find Full Text PDFThe long-term mining of vanadium-titanium (V-Ti) magnetite has generated a large accumulation of tailings, which can lead to metal pollution via microbial bioleaching. Current research has focused on the bioleaching of minerals, and a few studies have explored microbial responses to metals only through limited metabolite concentrations. However, the trigger mechanisms of metal release during the V-Ti magnetite tailing bioleaching and key gene regulatory pathways for organic acid metabolism are still unclear.
View Article and Find Full Text PDFWith the rapid development of mobile communication technology and wearable electronic devices, the electromagnetic radiation generated by high-frequency information exchange inevitably threatens human health, so high-performance wearable electromagnetic interference (EMI) shielding materials are urgently needed. The 2D nanomaterial MXene exhibits superior EMI shielding performance owing to its high conductivity, however, its mechanical properties are limited due to the high porosity between MXene nanosheets. In recent years, it has been reported that by introducing natural nanocellulose as an organic framework, the EMI shielding and mechanical properties of MXene/nanocellulose composites can be synergically improved, which are expected to be widely used in wearable multifunctional shielding devices.
View Article and Find Full Text PDFPurpose: Pseudoprogression is an atypical imaging pattern of response to immunotherapy in patients with brain tumors. MR perfusion studies in this field are limited. The purpose of our study is to compare the perfusion features between pseudoprogression lesions in malignant gliomas and brain metastases treated with immunotherapy (iPsP) and the pseudoprogression after chemo-radiation therapy and radiation necrosis after radiation treatment (ChR-PsP & RN).
View Article and Find Full Text PDFBackground And Aim: Prognosis in autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC) has historically been poor. This multicenter retrospective cohort study investigated the natural history and assessed the predictors of outcomes in patients with AIH, PBC, and PSC.
Methods: AIH, PBC, and PSC patients were identified from the state-wide Hepascore and Clinical Outcome cohort.
This study explores the impact of short-term annealing on the thermal stability and mechanical properties of oxygen-free copper subjected to high-pressure torsion (HPT). Copper samples were deformed through HPT with varying numbers of turns at room temperature and subsequently subjected to short-term annealing at temperatures of 398 K and 423 K. Microstructural analysis revealed that annealing led to grain growth and a reduction in dislocation density, with samples processed with fewer HPT turns exhibiting more significant grain coarsening.
View Article and Find Full Text PDFThe application of tyrosine kinase inhibitors (TKIs) has revolutionized the management of chronic myeloid leukemia (CML). However, disease relapse and progression particularly due to persistent leukemia stem cells (LSCs) remain a big challenge in the clinic. Therefore, validation of the therapeutic vulnerability in LSCs is urgently needed.
View Article and Find Full Text PDFObjective: Surgery to correct the cervicothoracic kyphotic deformity in ankylosing spondylitis (AS) can be associated with serious neurovascular risks. According to the literature, there are no clinical reports documenting the use of vertebral column decancellation (VCD) in the treatment of cervicothoracic kyphotic deformity in patients with AS. The purpose of the present study was to retrospectively analyze and evaluate the effect of VCD on cervicothoracic kyphotic deformity in patients with AS.
View Article and Find Full Text PDFThis study aimed to investigate the effects of pH on the structural properties and interaction mechanisms of zein/epicatechin gallate (ECG) complexes. QCM-D data demonstrated that the binding capacity of ECG to zein was significantly higher under alkaline condition (pH 9) compared to neutral and acidic conditions ( < 0.05).
View Article and Find Full Text PDFFibroblast growth factor 21 (FGF21) is a key regulator of metabolism and cardiovascular health. However, its upregulation in aging and age-related disorders suggests the presence of FGF21 resistance. This study aimed to elucidate the mechanisms underlying senescence-associated FGF21 resistance in human umbilical vein endothelial cells (HUVECs) and to explore potential therapeutic interventions.
View Article and Find Full Text PDFVascular aging (VA) is a common etiology of various chronic diseases and represents a major public health concern. Intermittent hypoxia (IH) associated with obstructive sleep apnea-hypopnea syndrome (OSAHS) is a primary pathological and physiological driver of OSAHS-induced systemic complications. A substantial proportion of OSAHS patients, estimated to be between 40% and 80%, have comorbidities such as hypertension, heart failure, coronary artery disease, pulmonary hypertension, atrial fibrillation, aneurysm, and stroke, all of which are closely associated with VA.
View Article and Find Full Text PDFThe prevalence and evolution of foamy viruses (FVs) have become the focus of research because of the risk of new zoonotic diseases. FVs have been isolated from various mammals and exhibit long-term co-speciation with their hosts. They also appear to be mild and nonpathogenic to their hosts.
View Article and Find Full Text PDFAntimicrob Agents Chemother
December 2024
The multidrug-resistant clonal complex 92 is spreading worldwide due to its high-frequency gene mutation and recombination, posing a significant threat to global medical and health safety. Between November 2021 and April 2022, a total of 132 clinical isolates were collected from a tertiary hospital in China. Their growth ability and virulence of these isolates were assessed using growth curve analyses and the infection model.
View Article and Find Full Text PDFWith the ongoing development of renewable energy sources, information technologies and physical energy systems are further integrated, which leads to challenges in ensuring the secure and stable operation of renewable energy power systems in the face of potential cyber threats. The strengths of blockchain in cybersecurity make it a promising solution to these challenges. However, existing blockchains are not well-suited for control tasks due to their low real-time performance.
View Article and Find Full Text PDFTo evaluate the predictive effect of transvaginal ultrasound measurement of cervical length and cervical elasticity examination on cervical insufficiency in twin pregnancies. Data from twin pregnant women in our hospital were collected retrospectively, including relevant vaginal ultrasound parameters (e.g.
View Article and Find Full Text PDFBackground: Thyroid surgeries are intricate operations that carry the risk of damaging the parathyroid glands, which can result in hypocalcemia and potential long-term hypoparathyroidism. Innovative surgical techniques including Intraoperative Nanocarbon Staining (INS), aim to enhance the preservation of parathyroid glands. This study assesses the effectiveness of INS combined with parathyroid autotransplantation in reducing postoperative complications and preserving parathyroid function.
View Article and Find Full Text PDFAcute myeloid leukemia (AML) is a hematological cancer prevalent worldwide. Anoikis-related genes (ARGs) are crucial in the progression of cancer and metastasis of tumors. However, their role in AML needs to be clarified.
View Article and Find Full Text PDFMicromachines (Basel)
November 2024