Publications by authors named "Yi He Zhang"
Eukaryotic Elongation Factor 2 Kinase (eEF2K), a member of the α-kinase family, services as a crucial negative regulator of protein synthesis, particularly under conditions of cellular stress. A pan-cancer analysis of eEF2K expression, genetic variants, and clinical relevance across multiple tumor types was performed using data from the Cancer Genome Atlas (TCGA) and GEO. Our findings suggest that eEF2K has dual roles in cancer progression, with its expression correlating with patient prognosis.
View Article and Find Full Text PDFsp. nov. and sp. nov., isolated from Antarctic intertidal sediment and Arctic soil, respectively.
Int J Syst Evol Microbiol
July 2024
Article Synopsis
- Two new Gram-stain-negative bacterial strains, IT1137 and S025, were isolated from sediments in Maritime Antarctica and soil in the High Arctic, respectively.
- Genetic and phenotypic tests (including 16S rRNA sequencing and various biochemical tests) were conducted to analyze the characteristics of these strains.
- The analysis indicated that these strains are distinct from known species, leading to the proposal of two new species names for them.
Article Synopsis
- - Pseudomonas species play a vital role in ecosystems due to their diverse metabolic capabilities and wide ecological reach, and strain IT1137 was specifically isolated from Antarctic intertidal sediment.
- - The genome of Pseudomonas sp. IT1137 consists of a large circular chromosome and a plasmid, containing thousands of protein-coding genes as well as genes related to nutrient cycling, alkane degradation, and other functions.
- - This strain shows promise for biotechnological uses such as bioremediation and the production of valuable secondary metabolites, enhancing our understanding of bacterial survival and roles in cold coastal environments.
Article Synopsis
- Oceanisphaera sp. IT1-181 is a newly identified bacterium isolated from intertidal sediment near the Chinese Great Wall Station in Antarctica, showcasing its broad distribution in marine environments.
- The complete genome of strain IT1-181 consists of a single chromosome and five plasmids, containing a total of 3,229 protein-coding genes, along with 88 tRNA and 25 rRNA genes.
- Analysis of its genome indicates it may be a unique species capable of producing ectoine and poly-β-hydroxybutyric acid, as well as exhibiting a complete CRISPR-Cas system, highlighting its potential applications in biotechnology and its ecological importance in the Antarctic.
This study aimed to investigate network-level brain functional changes in breast cancer patients and their relationship with fear of cancer recurrence (FCR). Resting-state functional MRI was collected from 43 patients with breast cancer and 40 healthy controls (HCs). Graph theory analyses, whole-brain voxel-wise functional connectivity strength (FCS) analyses and seed-based functional connectivity (FC) analyses were performed to identify connection alterations in breast cancer patients.
View Article and Find Full Text PDFMembers of the genus Pseudomonas have been frequently isolated from the marine environment, indicating their ecological role in native habitats. One bacterial strain, Pseudomonas sp. BSw22131, was isolated from seawater in Kongsfjorden, Svalbard.
View Article and Find Full Text PDFObjective: This is a single-center retrospective analysis of the clinical data of 516 patients with acute ischemic stroke who underwent intravenous thrombolysis. This study was conducted to compare the therapeutic efficacy of smokers and non-smokers.
Methods: Univariate analysis was used to analyze and compare the clinical data of smokers and non-smokers.
Article Synopsis
- * She underwent carbon ion radiotherapy (CIRT) to treat both cancers, receiving different doses for each type.
- * Three months after treatment, her choroidal melanoma was gone, and the lung cancer disappeared after seven months, indicating complete remission.
The optimal timing of glucocorticoid treatment for coronavirus disease 2019 (COVID-19) pneumonia is uncertain. We evaluated the clinical outcomes of methylprednisolone therapy (MPT) for patients with a high-risk common type (HRCT) COVID-19 pneumonia. We conducted a multicenter retrospective cohort study in Northeast China.
View Article and Find Full Text PDFBackground: Radical cystectomy is considered the first choice for the treatment of muscle-invasive bladder cancer. However, for some patients who have lost the indications for surgery, external beam radiotherapy is a non-invasive and effective treatment.
Case Summary: A 76-year-old patient with bladder cancer who had serious comorbidities and could not tolerate surgery or chemotherapy came to the Wuwei Heavy Ion Center.
Article Synopsis
- A case study was conducted on a 44-year-old female patient with recurrent thymic carcinoma who exhibited both the bystander and abscopal effects following carbon-ion irradiation treatment.
- The patient had a history of thymic carcinoma and received prior treatments, but her condition recurred with multiple masses, prompting the use of carbon-ion radiotherapy.
- Post-treatment imaging showed significant shrinkage of both treated and untreated tumors, highlighting the potential of these effects and indicating the need for further research into their mechanisms.
Article Synopsis
- - The study aimed to identify factors linked to poor clinical outcomes in patients with acute ischemic stroke who underwent endovascular therapy, analyzing 265 cases from Jilin University between 2016 and 2019.
- - Results indicated that successful revascularization occurred in 84.5% of cases, but only 46% had a good prognosis after 90 days, with independent risk factors for poor outcomes being diabetes, tandem occlusion, high NIHSS score at admission, and general anesthesia.
- - The findings suggest that neurointerventionalists should consider these risk factors when making clinical decisions for acute ischemic stroke patients to improve outcomes.
Background And Purpose: Modified Thrombolysis in Cerebral Infarction (mTICI)2b/3 has been considered the criterion for successful reperfusion in endovascular treatment. This study aimed to compare the therapeutic safety and efficacy of mTICI2b and mTICI3 recanalization, and to analyze the factors related to outcomes in everyday clinical practice.
Materials And Methods: This is a single-center retrospective analysis of 224 patients who underwent successful thrombectomy (achieving a mTICI score ≥2b).
The genus Sulfitobacter has been mostly found in marine and hypersaline environments. Members of this genus were observed to be associated with marine microalgae by inducing cell death of algae and degrading of algae-derived dimethylsulfoniopropionate (DMSP). Here we reported the complete genome sequence of strain Sulfitobacter sp.
View Article and Find Full Text PDFArticle Synopsis
- * The Notch signaling pathway plays a crucial role in cell processes like proliferation and differentiation, and its deregulation has been linked to various diseases, including liver fibrosis.
- * This review discusses the role of the Notch signaling pathway in HSC activation and liver fibrosis and explores new research directions, biomarkers, and potential therapeutic targets.
Article Synopsis
- Tillage and straw incorporation significantly improve soil fertility and break the plough layer, especially when applied together in the 20-35 cm soil depth.
- A field experiment showed that two specific treatments, subsoil combined with straw (ST+S) and subsoil only (ST), had the best results in reducing soil density and promoting straw decomposition during the first year.
- Long-term effects were noted, with ST+S yielding better maize production than traditional or modified tillage methods, highlighting the sustainable benefits of this practice over several years.
Article Synopsis
- Network analysis is utilized to explore how white matter networks are affected in patients with subjective cognitive decline (SCD) and amnestic mild cognitive impairment (aMCI), both early stages of Alzheimer's disease (AD).
- In a study involving 36 normal controls, 21 SCD patients, and 33 aMCI patients, results showed that aMCI patients had significantly lower network efficiency compared to normal controls, while SCD patients exhibited intermediate values.
- The study found significant changes in betweenness centrality in key brain regions for aMCI patients, suggesting that structural network properties remain intact during SCD but are disrupted in aMCI, offering new insights into the progression of AD.
Protective effect of topiramate on hypoxic-ischemic brain injury in neonatal rat.
Asian Pac J Trop Med
June 2014
Article Synopsis
- - The study aimed to investigate how topiramate (TPM) can protect against brain injury caused by hypoxia and ischemia in neonatal rats, involving 360 subjects divided into four treatment groups.
- - Different dosages of TPM were administered, with treatments lasting over 10 days, and various neurological metrics such as brain water content, neuron-specific enolase (NSE), and GABA levels being measured at set intervals post-treatment.
- - Results indicated that both the conventional and degradation therapy groups experienced lower brain water content and NSE levels, as well as improved GABA levels and cognitive abilities compared to the ischemia and hypoxia group, suggesting that TPM has a protective effect on brain function.
Article Synopsis
- - The study investigates the Volt-ampere (V-A) characteristics of human acupoints, examining how these traits change with physiological or pathological conditions and exploring their underlying biophysical mechanisms.
- - Findings show that acupoints exhibit both non-linear and inertial characteristics, with lower electrical resistance being less common and distinct circadian rhythms in some areas; pathological conditions, particularly heart and stomach diseases, also alter these characteristics significantly.
- - It concludes that the inertia area of acupoints is a more sensitive indicator of physiological and pathological changes than the V-A area, making it a key focus for future research on the electrical properties of acupoints.