Publications by authors named "Yi Hang Zhu"
Objective: Thyroid eye disease (TED) is an immune-mediated disorder of the eye. Intravenous glucocorticoid (GC) is the first-line treatment for patients with active moderate-to-severe TED. However, the response rate is between 50% and 80%.
View Article and Find Full Text PDFObjective: Alemtuzumab-induced autoimmune thyroid events (AIATEs) are the most common adverse effects observed in relapsing-remitting multiple sclerosis (RRMS) patients. This study aims to explore the clinical and biochemical characteristics of such AIATEs, and to examine the risk factors for their occurrence, particularly for the worst clinical phenotype of fluctuating Graves' disease (GD).
Design, Patients, Measurements: We retrospectively analysed a real-life single-centre consecutive series of 57 RRMS patients treated with alemtuzumab whose clinical and biochemical parameters were collected before starting the treatment and then monthly during their follow-up.
Article Synopsis
- A study evaluated clinical and molecular outcomes in differentiated thyroid carcinoma (DTC) across three groups: small tumors (≤ 40 mm), large tumors (> 40 mm), and those with distant metastases.
- Patients with metastatic DTC had the worst outcomes, experiencing higher rates of persistent disease, death, and need for further treatment, while outcomes were similar for non-metastatic groups regardless of size.
- Genetic analysis revealed distinct mutation patterns, with TERT promoter mutations indicating a worse prognosis, particularly in metastatic cases, and BRAF mutations being more common in smaller tumors.
Hickory (Carya cathayensis Sarg.) seed has one of the highest oil content and is rich in polyunsaturated fatty acids (PUFAs), which kernel is helpful to human health, particularly to human brain function. A better elucidation of lipid accumulation mechanism would help to improve hickory production and seed quality.
View Article and Find Full Text PDFUltra performance liquid chromatography/quadrupole-time-of-flight mass spectrometry (UPLC/QTOF MS) was employed to investigate the in vivo metabolism of liguzinediol. Urine, bile, feces and plasma samples were collected after intravenous administration of 10mg/kg liguzinediol to healthy rats. Altogether seven metabolites were detected and tentatively identified based on the characteristics of their protonated ions.
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