Effects of intensive wearing face masks on patients with postinfectious cough: A randomized controlled trial.

Background: Postinfectious cough was a common clinical symptom, which troubled patients and increased economic burden. The efficacy of pharmacotherapy for this symptom was unsatisfactory. This study aimed to explore the intervention effect of intensified mask-wearing on patients with post-upper respiratory tract infection cough and its role in reducing the economic burden of patients.

Characterization of Key Lipid Components in the Cell Membrane of Freeze-Drying Resistant Strains Using Nontargeted Lipidomics.

Lactic acid bacteria (LAB) are usually freeze-dried into powder for transportation and storage, with the bacterial membrane playing a crucial role in this process. However, different strains exhibit different levels of freeze-drying resistance in their cell membranes. In this study, () strains 1F20, K56, and J5, demonstrating survival rates of 59.

Artificial Intelligence Models May Aid in Predicting Lymph Node Metastasis in Patients with T1 Colorectal Cancer.

Background/aims: Inaccurate prediction of lymph node metastasis (LNM) may lead to unnecessary surgery following endoscopic resection of T1 colorectal cancer (CRC). We aimed to validate the usefulness of artificial intelligence (AI) models for predicting LNM in patients with T1 CRC.

Methods: We analyzed the clinical data, laboratory results, pathological reports, and endoscopic findings of patients who underwent radical surgery for T1 CRC.

Enhanced FFT-Root-MUSIC Algorithm Based on Signal Reconstruction via CEEMD-SVD for Joint Range and Velocity Estimation for FMCW Radar.

Frequency-modulated continuous-wave (FMCW) radar is used to extract range and velocity information from the beat signal. However, the traditional joint range-velocity estimation algorithms often experience significant performances degradation under low signal-to-noise ratio (SNR) conditions. To address this issue, this paper proposes a novel approach utilizing the complementary ensemble empirical mode decomposition (CEEMD) combined with singular value decomposition (SVD) to reconstruct the beat signal prior to applying the FFT-Root-MUSIC algorithm for joint range and velocity estimation.

A Leucine-Rich Receptor Like Kinase LRK2 Is Involved in the Regulation of Cold Tolerance and Yield in Rice.

Low temperature affects rice growth and yield. Receptor-like protein kinases play an important role in plant growth and development. In order to reveal the role of a leucine-rich receptor like kinase LRK2 in low temperature stress and growth and development of rice.

Defense-Related Enzyme Activities and Metabolomic Analysis Reveal Differentially Accumulated Metabolites and Response Pathways for Sheath Blight Resistance in Rice.

Rice sheath blight (RSB), caused by the pathogenic fungus , poses a significant threat to global food security. The defense mechanisms employed by rice against RSB are not well understood. In our study, we analyzed the interactions between rice and by comparing the phenotypic changes, ROS content, and metabolite variations in both tolerant and susceptible rice varieties during the early stages of fungal infection.

Triptolide Causes Spermatogenic Disorders by Inducing Apoptosis in the Mitochondrial Pathway of Mouse Testicular Spermatocytes.

Triptolide (TP) is a diterpenoid compound extracted from the traditional Chinese medicinal herb Tripterygium wilfordii. It has antitumor and anti-inflammatory effects and stimulates immunity. However, its serious side effects, especially reproductive toxicity, limit its clinical application.

Long-term correction of hemophilia A via integration of a functionally enhanced FVIII gene into the AAVS1 locus by nickase in patient-derived iPSCs.

Hemophilia A (HA) is caused by mutations in coagulation factor VIII (FVIII). Genome editing in conjunction with patient-derived induced pluripotent stem cells (iPSCs) is a promising cell therapy strategy, as it replaces dysfunctional proteins resulting from genetic mutations with normal proteins. However, the low expression level and short half-life of FVIII still remain significant limiting factors in the efficacy of these approaches in HA.

Benefit Finding Among Caregivers With Stroke: A Cross-Sectional Study.

To explore the level and influencing factors of caregivers' benefit finding in stroke patients from both the patient and caregiver perspectives. The growing number of stroke patients with physical impairments has presented significant challenges for caregivers. Benefit finding refers to the positive experience caregivers derive from their caregiving roles, which can help mitigate the adverse effects on their mental health.

Impact of aspect ratio and crystal size distribution of l-glutamic acid formed by cooling crystallization on drying characteristics.

This study investigated the impact of aspect ratio and crystal size distribution on the mother liquor content and drying rate of l-glutamic acid (LGA). LGA cooling crystallization was performed using two methods: spontaneous nucleation and seeding. First, to identify various crystalline forms of LGA and obtain α-form seeds, cooling crystallization was carried out through spontaneous nucleation and seeding.

RAP1 is essential for PRRSV replication and the synthesis of the viral genome.

Since its emergence, porcine reproductive and respiratory syndrome (PRRS) has caused enormous economic losses to the global swine industry. The pathogenesis of PRRS remains under investigation. The porcine reproductive and respiratory syndrome virus (PRRSV) causes reproductive disorders in pigs and respiratory in piglets, which is a 15 kb RNA virus that encodes 16 viral proteins, most of which exhibit multiple functions during the virus lifecycle.

Prosodic Modifications to Challenging Communicative Environments in Preschoolers.

Adapting one's speaking style is particularly crucial as children start interacting with diverse conversational partners in various communication contexts. The study investigated the capacity of preschool children aged 3-5 years ( = 28) to modify their speaking styles in response to background noise, referred to as noise-adapted speech, and when talking to an interlocutor who pretended to have hearing loss, referred to as clear speech. We examined how two modified speaking styles differed across the age range.

Prediction of Patient Drug Response via 3D Bioprinted Gastric Cancer Model Utilized Patient-Derived Tissue Laden Tissue-Specific Bioink.

Despite significant research progress, tumor heterogeneity remains elusive, and its complexity poses a barrier to anticancer drug discovery and cancer treatment. Response to the same drug varies across patients, and the timing of treatment is an important factor in determining prognosis. Therefore, development of patient-specific preclinical models that can predict a patient's drug response within a short period is imperative.

Population dynamics and the role of protected areas in China's milu deer (Elaphurus davidianus) rewilding.

Protected areas are refugia for wildlife and play a crucial role in biodiversity conservation, especially in the restoration of rare and endangered species. However, little attention has been paid to the long-term contribution of protected areas to rare species population rejuvenation. To identify the population growth of milu deer (Elaphurus davidianus)in protected areas and unprotected areas, we fitted the population dynamics curve of reintroduced free-ranging and wild populations based on long-term monitoring data in four protected areas: Jiangsu Dafeng Milu National Nature Reserve, Hubei Shishou Milu National Nature Reserve, Hunan East Dongting Lake National Nature Reserve, and Jiangxi Poyang Lake area.

Aberrant activation of adenine nucleotide translocase 3 promotes progression and chemoresistance in multiple myeloma dependent on PINK1 transport.

Chemoresistance is an important factor in multiple myeloma (MM) relapse and overall survival. However, the mechanism underlying resistance remains unclear. In this study, we identified adenine nucleotide translocase 3 (ANT3) as a novel biomarker and therapeutic target for MM progression and resistance to the proteasome inhibitor bortezomib (BTZ).

Effects of different lactic acid bacteria on the physicochemical properties, functional characteristics and metabolic characteristics of fermented hawthorn juice.

Lactic acid bacteria (LAB) fermentation enhances the flavour and functionality of juice substrates; however, research on hawthorn juice is limited. We hypothesize that due to strain specificity, the changes in hawthorn juice after fermentation with different LAB may vary. After selecting LAB strains based on pH and sensory evaluation, the physicochemical properties and anti-inflammatory potential in a lipopolysaccharide-induced RAW 264.

A microbiota-derived metabolite, 3-phenyllactic acid, prolongs healthspan by enhancing mitochondrial function and stress resilience via SKN-1/ATFS-1 in C. elegans.

The mechanisms underlying the impact of probiotic supplementation on health remain largely elusive. While previous studies primarily focus on the discovery of novel bioactive bacteria and alterations in the microbiome environment to explain potential probiotic effects, our research delves into the role of living Lactiplantibacillus (formerly known as Lactobacillus) and their conditioned media, highlighting that only the former, not dead bacteria, enhance the healthspan of Caenorhabditis elegans (C. elegans).

Core-shell vector-mediated co-delivery of CRISPR/Cas9 system and hydrophobic drugs against triple-negative breast cancer stem cells.

Cancer stem cells (CSCs) play an important role in the development of triple-negative breast cancer (TNBC), including metastasis, invasion, tumorigenicity, and drug resistance. Moreover, non-CSCs can spontaneously transform into CSCs in special tumor microenvironments, thereby leading to poor prognosis or even failed treatments. Therefore, reversing CSCs into normal tumor cells in a sustained-acting manner is a promising strategy.

Reversible right bundle branch block caused by spasm of the anterior septal branch: case report.

Background: Coronary Artery Spasm (CAS) often presents in the epicardial coronary arteries. The anterior septal branch is distributed within the myocardium, and occurrences of spasms are rare. Currently, there is no available literature on this topic, and the onset of symptoms remains elusive, potentially leading to misdiagnosis.

Experience of Venoarterial Extracorporeal Life Support-Assisted Brain Death Donation With Severe Hemodynamic Instability.

Objective: To explore the experience of extracorporeal life support (ECLS)-assisted maintenance of brain death donors with extremely unstable hemodynamics.

Methods: We retrospectively analyzed the clinical data of 12 brain-dead donors who received ECLS in our hospital from May 2015 to May 2022 due to extremely unstable hemodynamics. The organ acquisition status was analyzed.

[Advances in the anti-host interferon immune response of bluetongue virus].

Bluetongue virus (BTV) usually infects sheep, cattle, deer and other domesticated and wild ruminants through the bite of the vector insects, , causing bluetongue (BT). BT in subtropical and even temperate regions poses a serious threat to the development and international trade of the livestock industry. This article introduced the structure and cellular invasion, and summarized the mechanisms of anti-BTV immune response of host cells and antagonism of host cell innate immune response by the non-structural proteins (e.

Post-operative venous thromboembolism in patients after extracranial otologic surgery: A case series.

Objective: This study aimed to report 9 venous thromboembolism (VTE) cases after extracranial otologic surgery and analyze the potential risk factors.

Study Design: Case series.

Setting: Single tertiary-level academic center.

The STING antagonist SN-011 ameliorates cisplatin induced acute kidney injury via suppression of STING/NF-κB-mediated inflammation.

Acute kidney injury (AKI) is a critical clinical syndrome associated with both innate and adaptive immune responses and thus increases mortality. Nevertheless, specific therapeutics for AKI are scarce so far. Recent studies have revealed that knockout of STING alleviate AKI, suggesting that STING could be an attractive target for AKI therapy.

Heterologous expression, enzymatic properties, product analysis and molecular docking of assimilative nitrite reductase (NiR) in Bacillus velezensis GXMZU-B1 derived from mariculture.

High concentrations of nitrite stress aquatic animals, leading to significant fish and shrimp deaths as well as environmental pollution. Reducing nitrite levels in high-density aquaculture is crucial for both aquaculture safety and environmental protection. Nitrite reductase (NiR) can rapidly reduce nitrite in water, offering potential applications in aquaculture and water treatment.