Targeting ATM enhances radiation sensitivity of colorectal cancer by Potentiating radiation-induced cell death and antitumor immunity.

Introduction: The efficacy of radiotherapy in colorectal cancer (CRC) is often limited by radiation resistance. Ataxia telangiectasia mutated (ATM) is well known for its role in repairing double-strand DNA breaks within the DNA damage response (DDR) pathway. However, whether ATM mediates other mechanisms contributing to radiation resistance remains insufficiently investigated.

Discovery of 3-amide-pyrimidine-based derivatives as potential fms-like tyrosine receptor kinase 3 (FLT3) inhibitors for treating acute myelogenous leukemia.

FLT3-ITD and TKD mutants play a central role in acute myeloid leukemia (AML), making FLT3 an attractive target for AML treatment. To discover next-generation FLT3 inhibitors and gather additional structure-activity relationship (SAR) information, we performed structural modifications of G-749 (denfivontinib) utilizing structure simplification and scaffold hopping strategies. Among these derivatives, MY-10 exhibited the most potent and selective inhibition of MV4-11 cell proliferation, demonstrating potent inhibitory activity against FLT3-ITD (IC = 6.

Commercial Cellulosic Paper-Based Solid Electrolyte for High-Temperature Lithium-Sulfur Batteries.

Solid-state lithium-sulfur (Li-S) batteries show promise for future electric mobility due to their high energy density potential. However, high internal impedance, Li polysulfide shuttling, and dendrite formation exist. Herein, we present a Li-rich cellulosic solid-state electrolyte (SSE) that, when paired with a sulfurized polyacrylonitrile (SPAN) cathode, leads to durable Li-S batteries for use in the room temperature to 50 °C range.

Comparison of efficacy and safety between unilateral biportal endoscopic transforaminal lumbar interbody fusion versus uniportal endoscopic transforaminal lumbar interbody fusion for the treatment of lumbar degenerative diseases: a systematic review and meta-analysis.

Background: This meta-analysis was performed to comprehensively evaluate the efficacy and safety of unilateral biportal endoscopic transforaminal lumbar interbody fusion (UBE-TLIF) versus uniportal endoscopic transforaminal lumbar interbody fusion (Endo-TLIF) for the treatment of lumbar degenerative diseases.

Methods: We electronically searched PubMed, Embase, Scopus, Web of Science, the Cochrane Library, the Wanfang Database, and China National Knowledge Infrastructure to identify controlled clinical studies on the efficacy and safety of UBE-TLIF and Endo-TLIF for lumbar degenerative diseases from database establishment to December 2023. Two researchers screened the literature, extracted data, and evaluated the risk of bias of the included studies.

Transport of particulate mercury along the reservoir- downstream - estuary continuum during the water-sediment regulation scheme period of Yellow River in 2018.

As an important link of mercury (Hg) migration and transformation from land to ocean, rivers have been significantly influenced by anthropogenic activities, resulting in unpredictable environmental influences on the basin and offshore areas. In this study, the particulate Hg content of sediments in Xiaolangdi Reservoir (XLDR), Lijin Hydrological Station, and the Yellow River estuarine area during the water-sediment regulation scheme (WSRS) period in 2018 were analyzed, the characteristics and influencing factors of particulate Hg transport were explored. Our results revealed that the transport flux of particulate Hg into the sea during WSRS was 8.

Revealing mechanisms of high protein accumulation in Graesiella emersonii WBG-1 under heterotrophic condition.

Low protein content under heterotrophic conditions limits the industrial production of proteins by microalgae. In this study, Graesiella emersonii WBG-1 efficiently synthesized and accumulated proteins (64.03%) under heterotrophic conditions, distinguishing it from other microalgae.

The role of the hypothalamus-gut microbiota in the pathogenesis of periparturient fatty liver disease in dairy cows.

During the periparturient period, dairy cows experience negative energy balance due to reduced feed intake, leading to adipose tissue breakdown, liver damage, and fat accumulation. This study examined the gut-liver-brain axis to explore the link between fatty liver disease, changes in hypothalamic appetite-related neurons, and microbiome shifts in dairy cows. Thirty cows were monitored, with daily DMI recordings and blood sampling.

Exploring the role and application of mitochondria in radiation therapy.

Mitochondria are pivotal in cellular energy metabolism, the oxidative stress response and apoptosis. Recent research has focused on harnessing their functions to enhance the efficacy of radiation therapy (RT). This review focuses on the critical functions and applications of mitochondria in radiation therapy, including the targeting of mitochondrial metabolism and the modulation of mitochondria-mediated cell death and immune responses.

An integrative nomogram based on MRI radiomics and clinical characteristics for prognosis prediction in cervical spinal cord Injury.

Objective: To construct a nomogram model based on magnetic resonance imaging (MRI) radiomics combined with clinical characteristics and evaluate its role and value in predicting the prognosis of patients with cervical spinal cord injury (cSCI).

Methods: In this study, we assessed the prognosis of 168 cSCI patients using the American Spinal Injury Association (ASIA) scale and the Functional Independence Measure (FIM) scale. The study involved extracting radiomics features using both manually defined metrics and features derived through deep learning via transfer learning methods from MRI sequences, specifically T1-weighted and T2-weighted images (T1WI & T2WI).

Nanoplatform for synergistic therapy constructed via the co-assembly of a reduction-responsive cholesterol-based block copolymer and a photothermal amphiphile.

The goal of combination cancer therapy, including chemo-phototherapy, is to achieve highly efficient antitumor effects while minimizing the adverse reactions associated with conventional chemotherapy. Nevertheless, enhancing the contribution of non-chemotherapeutic strategies in combination therapy is often challenging because this requires multiple active ingredients to be encapsulated in a single delivery system. However, most commonly used photothermal reagents are challenging to be loaded in large quantities and have poor biocompatibility.

Pedestrians' perceptions, fixations, and decisions towards automated vehicles with varied appearances.

Future automated vehicles (AVs) are anticipated to feature innovative exteriors, such as textual identity indications, external radars, and external human-machine interfaces (eHMIs), as evidenced by current and forthcoming on-road testing prototypes. However, given the vulnerability of pedestrians in road traffic, it remains unclear how these novel AV appearances will impact pedestrians' crossing behaviour, especially in relation to their multimodal performance, including subjective perceptions, gaze patterns, and road-crossing decisions. To address this gap, this study pioneers an investigation into the influence of AVs' exterior design, in conjunction with their kinematics, on pedestrians' road-crossing perception and decision-making.

Fructans with various molecular weights from Polygonatum cyrtonema Hua differentially ameliorate intestinal inflammation by regulating the gut microbiota and maintaining intestinal barrier.

Polysaccharides are recognized as the predominant active constituents of Polygonatum cyrtonema Hua, conferring a broad spectrum of benefits. However, the structure-activity relationship of Polygonatum cyrtonema polysaccharides (PCP) and oligosaccharides (PCOP) remains underexplored. In this study, we aimed to compare the chemical properties and biological activities of PCP and PCOP.

Advancing cancer diagnosis and prognostication through deep learning mastery in breast, colon, and lung histopathology with ResoMergeNet.

Cancer, a global health threat, demands effective diagnostic solutions to combat its impact on public health, particularly for breast, colon, and lung cancers. Early and accurate diagnosis is essential for successful treatment, prompting the rise of Computer-Aided Diagnosis Systems as reliable and cost-effective tools. Histopathology, renowned for its precision in cancer imaging, has become pivotal in the diagnostic landscape of breast, colon, and lung cancers.

Appendectomy, acute appendicitis, and gastrointestinal diseases: A Mendelian randomization study.

Background: Appendectomy is the standard treatment for acute appendicitis. However, the effects of appendectomy and acute appendicitis on gastrointestinal diseases are not fully understood.

Methods: Genetic variants associated with appendectomy and acute appendicitis at a genome-wide significance level (P ​< ​5.

The therapeutic effects of salvianolic acids on ischemic stroke: From molecular mechanisms to clinical applications.

Ischemic stroke (IS), primarily caused by cerebrovascular occlusion, poses a significant public health challenge with limited effective therapeutic options. Evidence suggests that salvianolic acids (SAs), mainly from Salvia miltiorrhiza Bunge, have been formulated into injections and are widely used in clinical treatments for cardiovascular and cerebrovascular diseases, including stroke. The pharmacological properties of SAs include reducing neuroinflammation, alleviating oxidative stress injury, inhibiting cellular apoptosis, preserving endothelial function, maintaining blood-brain barrier integrity, and promoting angiogenesis.

CPT1A mediates radiation sensitivity in colorectal cancer.

The prevalence and mortality rates of colorectal cancer (CRC) are increasing worldwide. Radiation resistance hinders radiotherapy, a standard treatment for advanced CRC, leading to local recurrence and metastasis. Elucidating the molecular mechanisms underlying radioresistance in CRC is critical to enhance therapeutic efficacy and patient outcomes.

Video- assisted thoracoscopic lung resection with or without enhanced recovery after surgery: a single institution, prospective randomized controlled study.

Purpose: This study was conducted to evaluate the postoperative short-term outcomes of patients undergoing video-assisted thoracoscopic surgery (VATS) for lung resection with the enhanced recovery after surgery (ERAS) protocol.

Methods: A single-institution, prospective randomized controlled study was conducted. The primary outcome measures were postoperative pulmonary complications (PPCs) and postoperative short-term effects.

Gut-derived IL-13 contributes to growth via promoting hepatic IGF-1 production.

Background: The gut microbiota has a profound effect on immunity and metabolic status of the host, which has increasingly attracted research communities. However, the intrinsic mechanism underlying the interplay among these three aspects remains unclear.

Results: Different immune states were established via shaping the population structure of gut microbiota with antibacterial agents.

Diabetes in China part 2: prevention, challenges, and progress.

During the past 40 years, the prevalence of diabetes in China has increased from less than 1·0% in 1980 to 12·4% in 2018, an increase in line with the rapid growth of the nation's economy. To address such a burden, the Healthy China 2030 initiative and subsequent Action Plan, including a diabetes prevention and control campaign, were launched. A shift from a disease-centred approach to a health-centred approach and from treatment to prevention is the core of the Action Plan and diabetes management in China.

Response of platelet count in the US population following exposure to BDEs and BB: A cross-sectional analysis of database of NHANES (2007-2016).

Brominated flame retardants (BFRs) are environmental pollutants linked to health risks, including increased platelet (PLT) levels that may elevate the risk of thrombosis and cardiovascular diseases. This study examined the association between BFR exposure and PLT levels among 5831 adult participants from the National Health and Nutrition Examination Survey (NHANES) (2007-2016). Of the 12 BFRs analyzed, BB153, BDE17, BDE85, BDE154, BDE183, and BDE209 showed significant positive correlations with PLT levels (p < 0.