The characteristics of vHIT gain and PR score in peripheral vestibular disorders.

Background: Clinical application of vHIT is limited due to a lack of interpretation of vHIT gain and saccades.

Objectives: This research focuses on comparing common vertigo diseases on vHIT gain and saccade divergence(PR score).

Material And Methods: We retrospectively reviewed 165 patients who have one definite diagnosis, good data quality, and can be read by MATLAB software.

A multi-responsive chemosensor for highly sensitive and selective detection of Fe, Cu, CrO and nitrobenzene based on a luminescent lanthanide metal-organic framework.

Excessive release of some hazardous chemicals, such as Fe, Cu, CrO and nitrobenzene, may endanger public health and the environment; therefore, targeted effective sensing strategies are important. In this report, a series of lanthanide-based metal-organic frameworks (Ln-MOFs), namely {[Ln(dpc)(2HO)]·(Hbibp)} (Hdpc = 2-(3',4'-dicarboxylphenoxy) isophthalic acid, bibp = 4,4'-bis(imidazolyl) biphenyl, for I-VI, Ln = La, Ce, Pr, Nd, Sm, and Eu) were hydrothermally synthesized and characterized. Single-crystal X-ray diffraction indicates that I-VI are isostructural and the lanthanide center is nine-coordinated with a distorted tetrakaidecahedral configuration.

Musical Experience Offsets Age-Related Decline in Understanding Speech-in-Noise: Type of Training Does Not Matter, Working Memory Is the Key.

Objectives: Speech comprehension under "cocktail party" scenarios deteriorates with age even in the absence of measurable hearing loss. Musical training is suggested to counteract the age-related decline in speech-in-noise (SIN) perception, yet which aspect of musical plasticity contributes to this compensation remains unclear. This study aimed to investigate the effects of musical experience and aging on SIN perception ability.

The combined application of rat bone marrow mesenchymal stem cells and bioceramic materials in the regeneration of dental pulp-like tissues.

This study aims to observe the effects of the combined application of rat bone marrow mesenchymal stem cells (rBMSCs) and a bioceramic material on pulp-like tissue formation. Rat incisor root fragments without pulp tissues were prepared and filled with a collagen scaffold seeded with rBMSCs, while one side of the root segment was covered by a bioceramic material (iRoot BP). After they were cultured for 12 hours, the root fragments were implanted subcutaneously for 3 months.

Synthesis and biological evaluation of geniposide derivatives as potent and selective PTPlB inhibitors.

Herein a series of Geniposide derivatives were designed, synthesized and evaluated as protein tyrosine phosphatase 1B (PTPlB) inhibitors. Most of these compounds exhibited potent in vitro PTP1B inhibitory activities, the representative 7a and 17f were found to be the most potent inhibitors against the enzyme with IC values of 0.35 and 0.

The Utility of Native MS for Understanding the Mechanism of Action of Repurposed Therapeutics in COVID-19: Heparin as a Disruptor of the SARS-CoV-2 Interaction with Its Host Cell Receptor.

The emergence and rapid proliferation of the novel coronavirus (SARS-CoV-2) resulted in a global pandemic, with over 6,000,000 cases and nearly 400,000 deaths reported worldwide by the end of May 2020. A rush to find a cure prompted re-evaluation of a range of existing therapeutics vis-à-vis their potential role in treating COVID-19, placing a premium on analytical tools capable of supporting such efforts. Native mass spectrometry (MS) has long been a tool of choice in supporting the mechanistic studies of drug/therapeutic target interactions, but its applications remain limited in the cases that involve systems with a high level of structural heterogeneity.

Laser-Generated Supranano Liquid Metal as Efficient Electron Mediator in Hybrid Perovskite Solar Cells.

Creating colloids of liquid metal with tailored dimensions has been of technical significance in nano-electronics while a challenge remains for generating supranano (<10 nm) liquid metal to unravel the mystery of their unconventional functionalities. Present study pioneers the technology of pulsed laser irradiation in liquid from a solid target to liquid, and yields liquid ternary nano-alloys that are laborious to obtain via wet-chemistry synthesis. Herein, the significant role of the supranano liquid metal on mediating the electrons at the grain boundaries of perovskite films, which are of significance to influence the carriers recombination and hysteresis in perovskite solar cells, is revealed.

Transcutaneous electrical acupuncture stimulation (TEAS) for gastrointestinal dysfunction in adults undergoing abdominal surgery: study protocol for a prospective randomized controlled trial.

Background: Postoperative gastrointestinal (GI) dysfunction (PGD) is a common problem after abdominal surgery. PGD can increase the length of hospital stay and may lead to serious complications. Acupuncture and moxibustion are alternative therapies for PGD that have been used in some settings.

Reversible Potassium Intercalation in Blue Phosphorene-Au Network Driven by an Electric Field.

Foreign atom intercalation into an interface alters the strength of interlayer interaction and leads to the novel types of desirable properties. Here, we report an investigation via scanning tunnelling microscopy (STM) and scanning tunnelling spectroscopy (STS) of reversible potassium (K) intercalation in the blue phosphorene (blueP)-Au network that can be locally induced by an external electric field. The unique structure of the blueP-Au network provides large space in its pores for the intercalation and deintercalation process.

The utility of native MS for understanding the mechanism of action of repurposed therapeutics in COVID-19: heparin as a disruptor of the SARS-CoV-2 interaction with its host cell receptor.

The emergence and rapid proliferation of the novel coronavirus (SARS-CoV-2) resulted in a global pandemic, with over six million cases and nearly four hundred thousand deaths reported world-wide by the end of May 2020. A rush to find the cures prompted re-evaluation of a range of existing therapeutics vis-à-vis their potential role in treating COVID-19, placing a premium on analytical tools capable of supporting such efforts. Native mass spectrometry (MS) has long been a tool of choice in supporting the mechanistic studies of drug/therapeutic target interactions, but its applications remain limited in the cases that involve systems with a high level of structural heterogeneity.

Conversion of Intercalated MoO to Multi-Heteroatoms-Doped MoS with High Hydrogen Evolution Activity.

Lack of effective strategies to regulate the internal activity of MoS limits its practical application for hydrogen evolution reactions (HERs). Doping of heteroatoms without forming aggregation or an edge enrichment is still challenging, and its effect on the HER needs to be further explored. Herein, a two-step method is developed to obtain multi-metal-doped H-MoS , which includes intercalation of the layered MoO precursor with a following sulfurization.

Butyrate alleviates diabetic kidney disease by mediating the miR-7a-5p/P311/TGF-β1 pathway.

It has been reported that butyrate played an protect role in diabetic kidney disease (DKD) while the mechanism was still not clear. Transforming growth factor-β1 (TGF-β1) is the initial factor which triggers the profibrotic signaling cascades. P311 is an RNA-binding protein, which could stimulate TGF-β1 translation in several cell types.

Controlled hydrogenation into defective interlayer bismuth oxychloride via vacancy engineering.

Hydrogenation is an effective approach to improve the performance of photocatalysts within defect engineering methods. The mechanism of hydrogenation and synergetic effects between hydrogen atoms and local electronic structures, however, remain unclear due to the limits of available photocatalytic systems and technical barriers to observation and measurement. Here, we utilize oxygen vacancies as residential sites to host hydrogen atoms in a layered bismuth oxychloride material containing defects.

Juvenile polyposis syndrome might be misdiagnosed as familial adenomatous polyposis: a case report and literature review.

Background: Juvenile polyposis syndrome (JPS) is a rare disorder characterized by the presence of multiple juvenile polyps in the gastrointestinal tract, and germline mutations in SMAD4 or BMPR1A. Due to its rarity and complex clinical manifestation, misdiagnosis often occurs in clinical practice.

Case Presentation: A 42-year-old man with multiple pedunculated colorectal polyps and concomitant rectal adenocarcinoma was admitted to our hospital.

Nanoscale piezoelectric effect of biodegradable PLA-based composite fibers by piezoresponse force microscopy.

The piezoelectricity of the biocompatible and biodegradable polymer polylactic acid (PLA) was investigated as a potential magnetoelectric (ME) nanocomposite for biomedical applications. A key focus was to quantify the piezoelectric properties of single PLA fibers while tuning their polymer degradability through the addition of faster degrading polymer, poly (DL-lactide-co-glycolide) (PLGA), which is not a piezoelectric polymer. Piezoresponse Force Microscopy (PFM) showed that electrospun PLA fibers gave a piezoelectric response of 186 ± 28 pm.

Effect of Acupuncture for Postprandial Distress Syndrome: A Randomized Clinical Trial.

Background: Postprandial distress syndrome (PDS) is the most common subtype of functional dyspepsia. Acupuncture is commonly used to treat PDS, but its effect is uncertain because of the poor quality of prior studies.

Objective: To assess the efficacy of acupuncture versus sham acupuncture in patients with PDS.

Hydrogen Terminated Germanene for a Robust Self-Powered Flexible Photoelectrochemical Photodetector.

As a rising star in the family of graphene analogues, germanene shows great potential for electronic and optical device applications due to its unique structure and electronic properties. It is revealed that the hydrogen terminated germanene not only maintains a high carrier mobility similar to that of germanene, but also exhibits strong light-matter interaction with a direct band gap, exhibiting great potential for photoelectronics. In this work, few-layer germanane (GeH) nanosheets with controllable thickness are successfully synthesized by a solution-based exfoliation-centrifugation route.

Lung protective ventilation in infants undergoing cardiopulmonary bypass surgery for congenital heart disease: A prospective randomized controlled trial.

Background: Lung protective ventilation (LPV) has been applied to surgical adults with normal pulmonary function for optimizing mechanical ventilation and reducing postoperative pulmonary complications. Few studies have reported the use of LPV in infants undergoing cardiac surgery with cardiopulmonary bypass (CPB).

Aims: To explore safety and effectiveness of LPV in infants undergoing CPB surgery for congenital heart disease (CHD).

High heterogeneity of bacterioplankton community shaped by spatially structured environmental factors in West Lake, a typical urban lake in eastern China.

Elucidating the bacterioplankton spatial distribution patterns and its determinants is a central topic in ecological research. However, research on the distribution patterns of bacterioplankton community composition (BCC) within a small-sized, highly dynamic freshwater lake remains unclear. In this study, we collected surface water samples from West Lake to investigate the spatiotemporal variation of BCC by 16S rRNA gene high-throughput sequencing.

Transition-Metal Substitution-Induced Lattice Strain and Electrical Polarity Reversal in Monolayer WS.

The physical and chemical properties of transition metal dichalcogenides can be effectively tuned by doping or alloying, which is essential for their practical applications. However, the microstructure evolutions and their effects on the physical properties induced by alloying from hetero-atoms with different outermost electronic structures are still unclear. Here, we synthesized Nb-substituted WS with various Nb concentrations showing unusual changes of optical behaviors and continuous electrical polarity reversal.

Efficient Ammonia Electrosynthesis from Nitrate on Strained Ruthenium Nanoclusters.

The limitations of the Haber-Bosch reaction, particularly high-temperature operation, have ignited new interests in low-temperature ammonia-synthesis scenarios. Ambient N electroreduction is a compelling alternative but is impeded by a low ammonia production rate (mostly <10 mmol g h), a small partial current density (<1 mA cm), and a high-selectivity hydrogen-evolving side reaction. Herein, we report that room-temperature nitrate electroreduction catalyzed by strained ruthenium nanoclusters generates ammonia at a higher rate (5.

Embedding few-layer TiCT into alkalized g-CN nanosheets for efficient photocatalytic degradation.

Solution of the increasingly important problem of aquatic pollution requires the use of an economical, energy-efficient, highly effective and environmentally-friendly catalyst. Polymeric carbon nitride (CN) has shown to be a promising metal-free photocatalyst that however suffers from strong charge recombination and poor conductivity, while MXenes have shown to be perfect co-catalysts for the photocatalytic process but show poor stability. In this study, we successfully constructed a robust heterostructure photocatalyst in which few-layer TiCT was embedded into alkalized CN without being oxidized.