Comparison of Pain Reduction and Changes in Serum Cortisol and Glucose Levels to Different Doses of Lumbar Epidural Dexamethasone: A Prospective Study.

Background: Lumbar epidural steroid injection (LESI) is an effective treatment for low back pain. However, it may result in increased blood glucose levels, decreased plasma cortisol concentrations, and suppression of the adrenocorticotropic hormone axis.

Objective: We investigated the effects of 4 mg and 8 mg of dexamethasone as an LESI on back pain and the resulting changes in serum cortisol and glucose levels.