Publications by authors named "Ygor Schleier"
This work aimed at testing the hypothesis that NOD/ShiLtJ mice (NOD) recapitulate the cardiac disturbances observed on type 1 diabetes (T1D). NOD mice were studied 4 weeks after the onset of hyperglycemia, and NOR/Lt mice matched as control. Cardiac function was evaluated by echocardiography and electrocardiography (ECG).
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- - Hypothyroidism causes changes in heart electrical activity that can lead to dangerous heart rhythms (arrhythmias), particularly influenced by high levels of thyrotropin (TSH), which is linked to worse health outcomes.
- - Researchers created two rat models to study the effects of low and high TSH levels on the heart, using methods like electrocardiograms and measuring ionic currents in heart cells.
- - While both hypothyroidism models showed increased calcium currents, only the primary hypothyroidism model (high TSH) had notable heart rhythm issues; TSH treatment also altered heart cell activity and decreased important potassium currents in myocytes.
Article Synopsis
- Cardiac arrhythmias can occur after kidney injury, particularly following renal ischemia-reperfusion (I/R), and this study investigates the role of the NLRP3 immune sensor in this process.
- Mice lacking NLRP3 or CASP1 did not show increased levels of IL-1β or the prolonged QJ intervals associated with arrhythmias seen in wild-type mice after renal I/R, suggesting a critical role of this pathway in cardiac electrical disturbances.
- The study also indicates that macrophages may play a role as sensors of tissue injury, and treatments targeting IL-1β could be a potential therapeutic strategy to mitigate cardiac issues following renal injury.