Publications by authors named "Ygor Daniel Ramos Dos Santos"
Layered double hydroxides (LDHs) as efficient and safe carriers for miRNA inhibitors: In vitro and in vivo assessment of biocompatibility.
Chem Biol Interact
March 2024
Article Synopsis
- Layered double hydroxides (LDHs) show potential as nano-sized carriers for delivering therapeutic molecules like miRNA-196b-5p inhibitors, but more research is needed for their safe use.
- The study synthesized and characterized Mg-Al-LDHs, testing their transfection efficiency and cytotoxicity in both thymic endothelial cells and Drosophila larvae, achieving a high transfection rate with no observed toxicity.
- Results indicate that LDHs are stable, biocompatible, and effective for miRNA delivery, supporting their use in functional inhibition assays.
An initial precipitating injury in the brain, such as after status epilepticus (SE), evolves into chronic temporal lobe epilepsy (TLE). We investigated changes in the miRNA composition of extracellular vesicles (EVs) in the forebrain after the establishment of SE-induced chronic TLE. We induced SE in young Fischer 344 rats through graded intraperitoneal injections of kainic acid, which resulted in consistent spontaneous recurrent seizures at ~ 3 months post-SE.
View Article and Find Full Text PDFMesial Temporal Lobe Epilepsy (mTLE) characterized by progressive development of complex partial seizures originating from the hippocampus is the most prevalent and refractory type of epilepsy. One of the remarkable features of mTLE is the rhythmic pattern of occurrence of spontaneous seizures, implying a dependence on the endogenous clock system for seizure threshold. Conversely, circadian rhythms are affected by epilepsy too.
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