Microsatellite-stable colorectal cancer (MSS-CRC) exhibits resistance to programmed cell death protein-1 (PD-1) therapy. Improving the infiltration and tumor recognition of cytotoxic T-lymphocytes (CTLs) is a promising strategy, but it encounters huge challenges from drug delivery and mechanisms aspects. Here, a zeolitic imidazolate framework (ZIF) coated with apoptotic body membranes derived from MSS-CRC cells is engineered for the co-delivery of ginsenoside Rg1 (Rg1) and atractylenolide-I (Att) to MSS-CRC, named as Ab@Rg1/Att-ZIF.
View Article and Find Full Text PDFNon-Hermitian skin effect and photonic topological edge states are of great interest in non-Hermitian physics and optics. However, the interplay between them is largely unexplored. Here, we propose and demonstrate experimentally the non-Hermitian skin effect constructed from the nonreciprocal flow of Floquet topological edge states, which can be dubbed "Floquet skin-topological effect.
View Article and Find Full Text PDFVortices in fluids and gases have piqued the human interest for centuries. Development of classical-wave physics and quantum mechanics highlighted wave vortices characterized by phase singularities and topological charges. In particular, vortex beams have found numerous applications in modern optics and other areas.
View Article and Find Full Text PDFAlthough the adsorption capacity of titanium xerogel(TAX) for arsenite(As(Ⅲ)) is high(254 mg·g), the adsorption rate is slow. Therefore, TAX was loaded onto activated carbon, sponge, and resin to fabricate a supported adsorbent, and the arsenite removal performance was evaluated. Except sponge, activated carbon and resin could successfully load TAX.
View Article and Find Full Text PDFIt is reported both experimentally and numerically that dual-band acoustic Fano resonances (AFRs) of low-frequency sound are realized by a compound unit array composed of two types of multiple-cavity unit cells with different inner radii. Eigenmode analyses show that two types of monopolar Mie resonance (MMR) modes can be observed below 650 Hz, which arise from the coupling resonance of the overall structure and the Helmholtz resonance of each resonance cavity, respectively. Based on the MMRs with the out-of-phase characteristic induced by the mutual coupling of the two types of unit cells, the dual-band AFRs, in which the quality factor of the AFR II can exceed 600 when the ratio of the inner radii is closed to 1.
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