Publications by authors named "Yexi Peng"
Targeted protein delivery with nanocarriers holds significant potential to enhance therapeutic outcomes by precisely directing proteins to specific organs or tissues. However, the complex interactions between nanocarriers and the biological environment pose considerable challenges in designing effective targeted delivery vehicles. In this study, we address this challenge by leveraging DNA-barcoded high-throughput screening.
View Article and Find Full Text PDFNoninvasive fluorescence imaging of renal function is a valuable technique for understanding kidney disease progression and the development of renal medicine. This technique requires sensitive imaging probes for reporting renal dysfunction accurately at early stage. Herein, a molecularly engineered imaging probe (800CW-PEG-COOH) was synthesized by simply PEGylating conventional near-infrared fluorophore IRDye800CW with NH-PEG-COOH (molecular weight ∼2100 Da) for early detection and staging of renal dysfunction through noninvasive real-time kidney imaging.
View Article and Find Full Text PDFArticle Synopsis
- Renal clearable nanoparticles can effectively eliminate from the body through the kidneys, preventing harmful accumulation, but their interactions with other organs like the liver are still not fully understood.
- This study focused on a specific type of nanoparticle (800CW-GS-Au) that, despite showing minimal liver accumulation, underwent modifications due to liver interactions, which could be detected in urine.
- The findings suggest a way to noninvasively measure liver glutathione levels through urine analysis, enhancing understanding of nanoparticle transport and paving the way for new diagnostic methods.