Publications by authors named "Yexi Huang"
Endoplasmic reticulum (ER) stress, a common cellular stress response induced by various factors that interfere with cellular homeostasis, may trigger cell apoptosis. Autophagy is an important and conserved mechanism for eliminating aggregated proteins and maintaining protein stability of cells, which is closely associated with ER stress and ER stress-induced apoptosis. In this paper, we report for the first time that Hhatl, an ER-resident protein, is downregulated in response to ER stress.
View Article and Find Full Text PDFAssociation of CCR6 functional polymorphisms with Primary Biliary Cholangitis.
J Transl Autoimmun
June 2024
Article Synopsis
- Biliary epithelial cells in primary biliary cholangitis (PBC) patients release specific chemokines that attract CCR6 T cells, resulting in their infiltration into the biliary epithelium.
- A multi-national genome-wide meta-analysis, including a cohort from Han Chinese, found significant single nucleotide polymorphisms (SNPs) linked to PBC, categorized into "protective" and "risk" groups.
- Further analysis revealed that only the "risk" SNPs were consistently associated with PBC in a separate Han Chinese cohort, indicating a genetic vulnerability specific to this population.