Publications by authors named "Yewen Xie"
Sulforaphane (SFN) is a compound derived from cruciferous plants. It has received considerable attention in recent years due to its effectiveness in cancer prevention and anti-inflammatory properties. The purpose of this study was to evaluate the antitumor potential of sulforaphane on colitis-associated carcinogenesis (CAC) through the establishment of a mouse model with AOM/DSS.
View Article and Find Full Text PDFYeast β-glucan is a polysaccharide purified from cell wall, and its multiple biological activities are essential for immune regulation. However, the effect of β-glucan on the intestinal immune response during colitis-associated colorectal cancer (CAC) is unclear. Here, we explore the possible role of β-glucan in the development of CAC.
View Article and Find Full Text PDFTumors can induce the generation and accumulation of immunosuppressive cells in -the tumor microenvironment (TME). Among them, tumor-educated dendritic cells (TEDCs) involved in tolerance induction contribute greatly to the progression of tumors. However, the mechanisms governing the immunosuppressive function of dendritic cells in the TME are unclear.
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- The study explores the role of histone deacetylase 9 (HDAC9) in the tumor microenvironment (TME) and its effects on inflammation and antitumor immunity.
- Using knockout mice, researchers found that a lack of HDAC9 led to decreased infiltration of CD8 dendritic cells (DCs) in tumors, which in turn promoted tumor progression.
- Findings indicate that HDAC9 levels in tumor stroma are positively correlated with CD8 T cell counts, suggesting it could serve as a potential biomarker for predicting patient responses to immune therapies.
Article Synopsis
- * The study investigated how exosomes from tumor cells affect DCs, finding that these exosomes hindered the development of DCs from myeloid precursors and caused cell death, while also impeding DC maturation and migration.
- * Treatment with tumor exosomes reduced the differentiation of Th1 cells, which are essential for anti-tumor immunity, and increased regulatory T (Treg) cells; blocking PD-L1 helped partially restore the immune response, highlighting its role in the suppression caused by tumor exosomes.*
The long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been recently shown to be dysregulated in several cancers. However, the mechanisms underlying the role of MALAT1 in breast cancer remain unclear. Herein, we showed that MALAT1 was aberrantly increased in breast cancer tissues and cells.
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