SS-OCTA assessment of fundus microvascular changes and their correlation with coronary lesion severity in severe coronary heart disease.

This study aimed to quantify fundus microvascular alterations in patients requiring revascularization for coronary heart disease (CHD) using swept-source optical coherence tomography angiography (SS-OCTA) and to investigate the correlation between these alterations and the severity of coronary artery lesions. SS-OCTA was employed to assess the fundus neurovascular parameters of all participants, while the Gensini score was utilized to gauge the severity of coronary artery lesions in observation group. A total of 98 participants (49 CHD patients and 49 controls) were included.

ChoroidSeg-ViT: A Transformer Model for Choroid Layer Segmentation Based on a Mixed Attention Feature Enhancement Mechanism.

Purpose: To develop a Vision Transformer (ViT) model based on the mixed attention feature enhancement mechanism, ChoroidSeg-ViT, for choroid layer segmentation in optical coherence tomography (OCT) images.

Methods: This study included a dataset of 100 OCT B-scans images. Ground truths were carefully labeled by experienced ophthalmologists.

Caspase-1 Inhibition Ameliorates Photoreceptor Damage Following Retinal Detachment by Inhibiting Microglial Pyroptosis.

Retinal detachment (RD) is a sight-threatening condition that occurs in several retinal diseases. Microglia that reside in retina are activated after RD and play a role in the death of photoreceptor cells. The involvement of microglial pyroptosis in the early pathological process of RD is still unclear.

Structural insights into the thermostability mechanism of a nitrile hydratase from Caldalkalibacillus thermarum by comparative molecular dynamics simulation.

Nitrile hydratase (NHase), an excellent bio-catalyst for the synthesis of amide compounds, was composed of two heterologous subunits. A thermoalkaliphilic NHase NHCTA1 (Tm = 71.3°C) obtained by in silico screening in our study exhibited high flexibility of α-subunit but excellent thermostability, as opposed to previous examples.

Massilia buxea sp. nov., isolated from a rock surface.

A Gram-stain-negative, rod-shaped and motile bacterial strain, designated A9, was isolated from the surface of rock collected from the shore of Nvshan lake in Mingguang, Anhui province, China. Phylogenetic analysis based on 16S rDNA sequence data showed that strain A9 was affiliated with the genus Massilia and showed the highest sequence similarities to Massilia plicata KCTC 12344 (98.8 %) and Massilia lurida CGMCC 1.