Publications by authors named "Yevheniia Porozhan"
Article Synopsis
- HP1α/CBX5 is linked to multiple sclerosis (MS), and a study found that some MS patients have lower CBX5 levels that relate to worse disease progression and significant changes in gene expression.* -
- The research identified problems with certain RNA species in these patients, suggesting that the Integrator complex, which is important for RNA processing, is less active, potentially raising MS risk.* -
- In experiments with mice lacking Cbx5, similar transcription issues were observed, indicating that HP1α/CBX5 plays a critical role in maintaining proper gene expression and could lead to new ways to categorize MS patients.*
Accumulation of senescent cells is an important contributor to chronic inflammation upon aging. The inflammatory phenotype of senescent cells was previously shown to be driven by cytoplasmic DNA. Here, we propose that cytoplasmic double-stranded RNA has a similar effect.
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