Publications by authors named "Yevgeniy Sazhnyev"
Glaucoma is a chronic optic neuropathy that leads to irreversible vision loss. Aging and family history are the two most important risk factors of glaucoma. One of the most studied genes involved in the onset of open-angle glaucoma is myocilin (MYOC).
View Article and Find Full Text PDFChoroidal Changes in Rhesus Macaques in Aging and Age-Related Drusen.
Invest Ophthalmol Vis Sci
September 2023
Article Synopsis
- The study investigates choroidal thickness and vascularity in aged rhesus macaques to understand changes related to aging and age-related macular degeneration (AMD).
- Using optical coherence tomography, researchers analyzed 244 eyes from 122 macaques, measuring various parameters including choroidal thickness (CT) and choroidal vascularity index (CVI), and assessing the impact of soft drusen.
- Findings show that choroidal thickness and vascularity decrease with age, but eyes with soft drusen are thicker and more vascular, displaying similarities to pachydrusen seen in human AMD patients.
Quantitative Fundus Autofluorescence in Rhesus Macaques in Aging and Age-Related Drusen.
Invest Ophthalmol Vis Sci
July 2020
Purpose: To employ quantitative fundus autofluorescence (qAF) imaging in rhesus macaques to noninvasively assess retinal pigment epithelial (RPE) lipofuscin in nonhuman primates (NHPs) as a model of aging and age-related macular degeneration (AMD).
Methods: The qAF imaging was performed on eyes of 26 rhesus macaques (mean age 18.8 ± 8.