Publications by authors named "Yetunde Adeola Olukosi"
Background: Routine surveillance for antimalarial drug resistance is critical to sustaining the efficacy of artemisinin-based Combination Therapies (ACTs). and non- artemisinin ART) resistance-associated mutations are uncommon in Africa. We investigated polymorphisms in actin-binding protein (Pfcoronin associated with reduced sensitivity to ART in Nigeria.
View Article and Find Full Text PDFAnopheles gambiae, An. coluzzii and An. arabiensis are the three major vectors of malaria in Nigeria.
View Article and Find Full Text PDFBackground: The decline in the efficacy of artemisinin-based combination treatment (ACT) in some endemic regions threatens the progress towards global elimination of malaria. Molecular surveillance of drug resistance in malaria-endemic regions is vital to detect the emergence and spread of mutant strains.
Methods: We observed 89 malaria patients for the efficacy of artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum infections in Lagos, Nigeria and determined the prevalence of drug resistant strains in the population.
Article Synopsis
- The study focuses on the genetic diversity of malaria parasites in patients from Okelele, a rural community in Nigeria, highlighting concerns regarding malaria's public health impact there.
- It analyzed 50 strains using specific genetic markers (Merozoite Surface Proteins and Glutamate Rich Protein) to assess infection types and diversity.
- Results showed higher rates of polyclonal infections for one genetic marker and higher monoclonal infections for another, indicating significant genetic diversity in the malaria strains present in the community.