Monoterpenoid indole alkaloids from the stems and leaves of and their potential antiproliferative activities.

A phytochemical study on the stems and leaves of led to the isolation and identification of a new monoterpenoid indole alkaloid, taberboviline (), together with seven known monoterpenoid indole alkaloids (2-8). The chemical structure of was elucidated on the basis of extensive spectral data analyses and the known compounds were identified by comparing their experimental spectral data with the reported data in the literature. All isolated indole alkaloids were evaluated for their antiproliferative activities against five human cancer cell lines .

Multifunctional Nanozyme with Aptamer-Based Ratiometric Fluorescent and Colorimetric Dual Detection of Prostate-Specific Antigen.

The adsorption of DNA probes onto nanomaterials represents a promising bioassay technique, generally employing fluorescence or catalytic activity to generate signals. A significant challenge is maintaining the catalytic activity of chromogenic catalysts during detection while enhancing accuracy by overcoming the limitations of single-signal transmission. This article presents an innovative multimodal analysis approach that synergistically combines the oxidase-like activity of Fe-N-C nanozyme (Fe-NC) with red fluorescent carbon quantum dots (R-CQDs), further advancing the dual-mode analysis method utilizing R-CQDs@Fe-NC.

Structurally diverse monoterpenoid indole alkaloids from as well as their potential anti-inflammatory and anti-HIV effects.

A phytochemical investigation on the stems and leaves of caused the isolation and characterisation of a new monoterpenoid indole alkaloid, damnahainanline (), as well as seven known analogues (-). The molecular structure of was determined in the light of comprehensive spectroscopic data analyses and the known analogues - were determined comparing their experimental spectroscopic data with the reported spectroscopic data in the literature. The anti-inflammatory effects as well as anti-HIV activities of all isolates - were assessed.

An Ultrasound-Triggered Nanoplatform for Synergistic Sonodynamic-Nitric Oxide Therapy.

Ultrasound (US)-triggered sonodynamic therapy (SDT) has aroused intensive interest as a powerful alternative for cancer treatment in recent years due to its non-invasiveness and deep tissue penetration. However, the therapeutic effect of SDT alone is still limited by intrinsic hypoxia in solid tumors. Combined synergistic therapy strategies are highly desired for improving therapeutic efficiency.

Modulation of hypoxia and redox in the solid tumor microenvironment with a catalytic nanoplatform to enhance combinational chemodynamic/sonodynamic therapy.

The efficacy of reactive oxygen species-mediated therapy is generally limited by hypoxia and overexpressed glutathione (GSH) in the tumor microenvironment (TME). To address these issues, herein, a smart MnO/OCN-PpIX@BSA nanoplatform is rationally developed to enhance the combinational therapeutic efficacy of chemodynamic therapy (CDT) and sonodynamic therapy (SDT) through TME modulation. For constructing the catalytic nanoplatform (MnO/OCN-PpIX@BSA), MnO nanoparticles were grown on oxidized g-CN (OCN) nanosheets, and the as-prepared MnO/OCN nano-hybrids were then successively loaded with protoporphyrin (PpIX) and coated with bovine serum albumin (BSA).

Gadolinium-doped hollow silica nanospheres loaded with curcumin for magnetic resonance imaging-guided synergistic cancer sonodynamic-chemotherapy.

Curcumin is a kind of anti-cancer chemotherapeutic drug and has been demonstrated to be able to produce reactive oxygen species (ROS) under the stimuli of ultrasound (US). Herein, gadolinium-doped hollow mesoporous silica nanospheres (Gd-HMSNs) loaded with curcumin (Cur) and conjugated with carboxymethyl dextran (CMD) have been facilely fabricated and applied for magnetic resonance imaging (MRI)-guided synergistic cancer sonodynamic-chemotherapy. The as-prepared multifunctional theranostic nanoplatform (Cur@Gd-HMSNs-CMD) shows high drug loading capacity, satisfactory biocompatibility, pH-responsive degradation, and US-triggered drug release.

Functionalized g-CN nanosheets for potential use in magnetic resonance imaging-guided sonodynamic and nitric oxide combination therapy.

The oxygen consumption-induced hypoxia and the high concentration of glutathione in tumor microenvironment limit the treatment outcomes of sonodynamic therapy (SDT). SDT needs to be combined with other treatment modalities to achieve the desired therapeutic efficiency. In this study, an oxidized g-CN (OCN) nanosheet-based theranostic nanoplatform is developed for sonodynamic and nitric oxide (NO) combination therapy of cancer.

Cylindrical shaped ZnO combined Cu catalysts for the hydrogenation of CO to methanol.

Hydrogenation of CO to chemicals is of great importance in the reduction of greenhouse gas emission. And the interaction and/or the boundary between Cu and ZnO played a crucial role in the performance of the Cu-ZnO catalyst for CO hydrogenation to methanol. In this work, cylindrical shaped ZnO was first synthesized controlled hydrothermal precipitation of Zn(COCH)·2HO, and Cu was further deposited on ZnO reduction in aqueous solution.