Long non-coding RNA ZFAS1 promotes ferroptosis by regulating the miR-185-5p/SLC25A28 axis in clear cell renal cell carcinoma.

Ferroptosis is a novel, iron-dependent regulated cell death mode. The biochemical features of ferroptosis include iron accumulation, lipid peroxidation, inhibition of glutathione peroxidase 4 (GPX4) and antioxidant glutathione (GSH) decrease through inhibition of the system xc transporter. Zinc finger NFX1 type-containing 1 (ZNFX1) antisense RNA 1 (ZFAS1) is a long non-coding RNA that has been identified as an oncogene in various types of cancers.

Combined fibrinogen concentration and neutrophil-to-lymphocyte ratio, an integrative model of the inflammatory response and coagulation cascades, for predicting prognosis in patients with upper tract urothelial carcinoma.

Inflammation and coagulation cascades are closely correlated with cancer occurrence and progression. This study investigated the prognostic value of the combination of plasma fibrinogen level and neutrophil-to-lymphocyte ratio (F-NLR) in patients with upper tract urothelial carcinoma (UTUC). The predictive ability of the F-NLR for overall survival (OS), cancer-specific survival (CSS), and progression-free survival (PFS) was initially established and then further validated in patients who underwent radical nephroureterectomy (RNU) for UTUC.

Comparative efficacy of non-pharmacological interventions for anxiety in adult intensive care unit patients: A systematic review and network meta-analysis.

Background: The primary goal of the intensive care unit is to the anxiety of conscious patients is often ignored in the care unit.

Aim: The purpose of this study was to assess the efficacy of various non-pharmacological therapies for anxiety disorders in adult patients in the intensive care unit, in order to enhance humanistic care in the intensive care unit and to promote the patients' physical and mental recovery together.

Study Design: We conducted a systematic and comprehensive search of the literature in five databases (including the Cochrane Library, PubMed, EBSCO, Web of Science, and Embase) covering nearly a decade for randomized controlled trials of non-pharmacological therapies to reduce anxiety in adult intensive care unit patients.

Synergistic photocatalysis for bacteria inactivation and organic pollutant removal by S-scheme heterojunction InVO/BiOI: Performance evaluation and mechanism investigation.

The low efficiency of charge carrier separation is a major limitation hindering the application of photocatalytic technology. Constructing S-scheme heterojunction photocatalysts not only effectively promotes the separation of charge carriers, but also maximizes the oxidative and reductive capabilities of the two monomers. In this study S-scheme heterogeneous InVO/BiOI photocatalyst was synthesized by hydrothermal method combined with calcination.

What Is the Impact of Baseline Inflammatory and Hemostatic Indicators with the Risk of Mortality in Severe Inpatients with COVID-19: A Retrospective Study.

The purpose of the study was to investigate baseline inflammatory, hemostatic indicators and new-onset deep vein thrombosis (DVT) with the risk of mortality in COVID-19 inpatients. In this single-center study, a total of 401 COVID-19 patients hospitalized in Sir Run Run Shaw Hospital, Zhejiang University School of Medicine were enrolled from December 1, 2022 to January 31, 2023. The basic information, first laboratory examination results, imaging examination, and outcome-related indicators were compared between patients in the moderate and severe subgroups.

Hyperhomocysteinemia is associated with the risk of venous thromboembolism in patients with mental illness: a case-control study.

Objective: The risk of venous thromboembolism in patients with mental illness has been insufficiently addressed. This study aimed to assess the correlation between hyperhomocysteinemia and venous thromboembolism prevalence among this population.

Methods: Patients with a diagnosis of mental illness and concurrent venous thromboembolism, admitted to Sir Run Run Shaw Hospital at Zhejiang University School of Medicine between January 2014 and December 2021, were included in the venous thromboembolism group.

Ginsenoside Rb1 induces hepatic stellate cell ferroptosis to alleviate liver fibrosis via the BECN1/SLC7A11 axis.

Liver fibrosis is primarily driven by the activation of hepatic stellate cells (HSCs), a process associated with ferroptosis. Ginsenoside Rb1 (GRb1), a major active component extracted from Panax ginseng, inhibits HSC activation. However, the potential role of GRb1 in mediating HSC ferroptosis remains unclear.

Lycopene from tomatoes and tomato products exerts renoprotective effects by ameliorating oxidative stress, apoptosis, pyroptosis, fibrosis, and inflammatory injury in calcium oxalate nephrolithiasis: the underlying mechanisms.

Several mechanisms underlying nephrolithiasis, one of the most common urological diseases, involve calcium oxalate formation, including oxidative stress, inflammatory reactions, fibrosis, pyroptosis, and apoptosis. Although lycopene has strong antioxidant activity, its protective effects against CaOx-induced injury have not yet been reported. This study aimed to systematically investigate the protective effects of lycopene and explore its mechanisms and molecular targets.

Effects of non-pharmacological interventions on pain in wound patients during dressing change: A systematic review.

Background: Changes to the wound dressing frequently cause pain. Some adverse side effects of pharmacologic pain management may cause problems or even impede wound healing. There is no systematic study of non-pharmacologic therapies for pain during wound dressing changes, despite the gradual promotion of non-pharmacologic pain reduction methods.

GDF15 affects venous thrombosis by promoting EndMT through smad2/p-smad2 pathway.

Background: Endothelial-to-mesenchymal transition (EndMT) is a pathophysiological change in the vascular endothelium commonly seen in the cardiovascular system. Elevated serum Growth differiention factor 15 (GDF15) has been reported in VTE patients, but the relationship and mechanism between GDF15, EndMT and VTE are still unclear.

Methods: We performed a retrospective clinical study, and human serum GDF15 expression levels were detected.

A novel Z-type heterojunction BiOCl/BiOI photocatalytic composite with broad-spectrum antibacterial activity and degradation properties.

At present, the sustainable development of humans is facing health problems and ecological imbalance caused by environmental pollution. To solve the bacteria, antibiotics and other pollutants in wastewater, BiOCl and BiOI with appropriate bandgap width were selected to prepare Z-type heterojunction BiOCl/BiOI photocatalytic materials by calcination method. Under LED light, the best sample BiOCl/BiOI-4 could completely inactivate Escherichia coli (E.

CircItgb5 promotes synthetic phenotype of pulmonary artery smooth muscle cells via interacting with miR-96-5p and Uba1 in monocrotaline-induced pulmonary arterial hypertension.

Background: Pulmonary arterial hypertension (PAH) is a rare but fatal cardiopulmonary disease mainly characterized by pulmonary vascular remodeling. Aberrant expression of circRNAs has been reported to play a crucial role in pulmonary vascular remodeling. The existing literature predominantly centers on studies that examined the sponge mechanism of circRNAs.

BiMoO nanoparticles anchored in BiOI: A p-n heterojunction photocatalyst to enhance water purification.

Selective constructing of heterojunctions enables directional electron-hole migration and favorable charge separation. In this study, a novel p-n junction BiMoO (BMO) nanoparticles anchored in BiOI construct by hydrothermal and subsequent in-situ synthesis. The construction of tight heterojunctions that enhance the characteristic absorption of visible light by BiMoO/BiOI (BIMO) and expose more reactive sites can be used to facilitate the rapid degradation of antibiotics (Tetracycline, TC), endocrine disruptors (Bisphenol A, BPA) and dyes in water.

Construction of a novel double S-scheme structure WO/g-CN/BiOI: Enhanced photocatalytic performance for antibacterial activity.

In recent years, the threat to human health from bacteria in wastewater has attracted attention, and photocatalytic technology has emerged as a promising strategy for inactivating bacteria in water. Therefore, it is of great research value to develop a novel high-efficiency photocatalytic system with the visible light response. We successfully designed a double S-scheme heterojunction composite WO/g-CN/BiOI (WCB) in this paper.

Fabrication of n-p β-BiO@BiOI core/shell photocatalytic heterostructure for the removal of bacteria and bisphenol A under LED light.

A novel n-p β-BiO@BiOI core/shell heterostructure was successfully constructed by a facile ultrasonication method. SEM, TEM, XRD and XPS confirmed the core/shell structure. UV-vis indicated the composite had good absorption of visible light.

Facile synthesis CQDs/SnO/BiOI heterojunction photocatalyst to effectively degrade pollutants and antibacterial under LED light.

To remove multitudinous pollutants from wastewater, the design of a highly efficient and multifunctional photocatalyst is necessary. A novel CQDs/SnO/BiOI photocatalyst (named CSnBI composite) was prepared by combining carbon quantum dots (CQDs), large specific surface area SnO nanocrystals and BiOI nanocrystals to obtain a compact hybrid structure. TEM and Raman techniques confirmed the structure of CSnBI composite.

Organoids in lung cancer: A teenager with infinite growth potential.

Despite the rapid advancement in lung cancer research, morbidity and mortality remain high in recent years. Therefore, deeper learning of the underlying molecular mechanisms of pathogenesis and discovery of novel effective therapeutic strategies of treatment in lung cancer research are around the corner. Among these, applying an efficient and reliable preclinical model would be a critical step that exists throughout the whole process.

Facile synthesizing Z-scheme BiOCl/InVO heterojunction to effectively degrade pollutants and antibacterial under light-emitting diode light.

The design of a photocatalytic system with Z-scheme heterojunction is the key to charge separation. In this paper, a simple synthesis method was used to prepare BiOCl/InVO photocatalyst. The synthesized photocatalyst can effectively degrade pollutants, and inactivate bacteria under LED light irradiation.

Constructing an S-scheme CuBiO/BiOI heterojunction for lightemittingdiode-driven pollutant degradation and bacterial inactivation.

The CuBiO/BiOI S-scheme heterojunction structure was constructed by a hydrothermal and subsequent calcination route. The combination of CuBiO and BiOI produced excellent photocatalytic performance under an LED light. A series of technical characterizations, including X-ray diffraction (XRD), scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS), were used to determine the successful construction of S-scheme CuBiO/BiOI composites.

Comprehensive Exploration of Tumor Microenvironment Modulation Based on the ESTIMATE Algorithm in Bladder Urothelial Carcinoma Microenvironment.

Recently, the tumor microenvironment (TME) has been reported to be closely related to the tumor initiation, progression, and prognosis. Bladder urothelial carcinoma (BLCA), one of the most common subtypes of bladder cancer worldwide, has been associated with increased morbidity and mortality in the past decade. However, whether the TME status of BLCA contributes to the prediction of BLCA prognosis still remains uncertain.

A Novel Prognostic Signature Based on Ferroptosis-Related Genes Predicts the Prognosis of Patients With Advanced Bladder Urothelial Carcinoma.

Bladder Urothelial Carcinoma (BLCA) is the major subtype of bladder cancer, and the prognosis prediction of BLCA is difficult. Ferroptosis is a newly discovered iron-dependent cell death pathway. However, the clinical value of ferroptosis-related genes (FRGs) on the prediction of BLCA prognosis is still uncertain.

A New Prognostic Risk Signature of Eight Ferroptosis-Related Genes in the Clear Cell Renal Cell Carcinoma.

Clear cell renal cell carcinoma (ccRCC) is the most common renal cell carcinoma and has poor prognosis in the locally advanced stage. Ferroptosis, a relatively new type of cell death, has gained significant attention in recent years. This study aimed to explore the prognostic value of ferroptosis-related genes (FRGs) in ccRCC.