Publications by authors named "Yeonju Cho"
Article Synopsis
- Metastasis is a big reason why many people die from cancer, and this study found specific cancer cells that help it spread.
- The researchers looked at how these cancer cells interact with other cells in their environment using a special imaging technique.
- They discovered that the cancer cells that cause metastasis are often found close to certain types of immune and connective tissue cells, which might help them spread even more.
Article Synopsis
- Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer that resists immunotherapy, largely due to an immunosuppressive environment created by myeloid cells.
- A combination of the PDE5 inhibitor tadalafil with a specific vaccine and immune checkpoint inhibitors shows promise in enhancing the immune response against PDAC, even in cases previously deemed immune-resistant.
- Tadalafil helps reprogram myeloid cells to reduce their suppression of T cells, leading to improved T cell activation and pro-inflammatory signaling, which boosts anti-tumor effects.
Senescent melanocytes are major contributors to age-related changes in the skin, highlighting the contribution to skin aging. Moreover, prolonged photodamage, such as that caused by UV exposure, can result in melanin accumulation and accelerated melanocyte senescence, thereby exacerbating aging. Melasolv™ is a substance that induces potent depigmentation effects and exhibits low toxicity.
View Article and Find Full Text PDFSubcutaneous adipose tissue (SAT), a vital energy reservoir and endocrine organ for maintaining systemic glucose, lipid, and energy homeostasis, undergoes significant changes with age. However, among the existing aging-related markers, only few genes are associated with SAT aging. In this study, weighted gene co-expression network analysis was used on a transcriptome of SAT obtained from the Genotype-Tissue Expression portal to identify biologically relevant, SAT-specific, and age-related marker genes.
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