Association between ε2 and Aβ burden in patients with Alzheimer- and vascular-type cognitive impairment.

Objective: To investigate the association between genotype and β-amyloid (Aβ) burden, as measured by PET in patients with subcortical vascular cognitive impairment (SVCI) and those with Alzheimer disease-related cognitive impairment (ADCI).

Methods: This was a cross-sectional study of 310 patients with SVCI and 999 with ADCI. To evaluate the effects of genotype or diagnostic group on Aβ positivity, we performed multivariate logistic regression analyses.

Application of an amyloid and tau classification system in subcortical vascular cognitive impairment patients.

Objective: To apply an AT (Aβ/tau) classification system to subcortical vascular cognitive impairment (SVCI) patients following recently developed biomarker-based criteria of Alzheimer's disease (AD), and to investigate its clinical significance.

Methods: We recruited 60 SVCI patients who underwent the neuropsychological tests, brain MRI, and F-florbetaben and F-AV1451 PET at baseline. As a control group, we further recruited 27 patients with AD cognitive impairment (ADCI; eight Aβ PET-positive AD dementia and 19 amnestic mild cognitive impairment).

Distinct Brain Regions in Physiological and Pathological Brain Aging.

Background: Studying structural brain aging is important to understand age-related pathologies, as well as to identify the early manifestations of the Alzheimer's disease (AD) continuum. In this study, we investigated the long-term trajectory of physiological and pathological brain aging in a large number of participants ranging from the 50s to over 80 years of age.

Objective: To explore the distinct brain regions that distinguish pathological brain aging from physiological brain aging using sophisticated measurements of cortical thickness.