Kinetically controlled morphology and composition of colloidal nanoparticles: cation exchange reactions from copper sulfide to transition metal (Mn, Zn, Fe, and Co) sulfides.

The cation exchange reaction is a powerful method for generating nanomaterials with unique structures because of the easy control of the size, morphology, composition, and crystal structure of the nanoparticles. This study investigated the kinetically controlled morphology and composition of colloidal nanoparticles (NPs) through cation exchange reactions, specifically focusing on variations from copper sulfide to transition metal sulfides, including Co, Fe, Zn, and Mn sulfides. In the cation exchange reaction, Co exhibited the fastest exchange rate, followed by Fe, Mn, and Zn.

Morphology Control of Au-Ni Hybrid Nanoparticles: Exploring Heterostructures and Optical Tuning.

Hybrid nanoparticles (NPs) have attracted considerable attention because of their ability to provide diverse properties by integrating the inherent properties of multiple components; however, synthetic strategies to control their morphology remain unexplored. In this study, a new method was used to control the morphology and optical properties of Au-Ni heterostructure (ANH) NPs. Unique morphological changes were observed by varying the Au/Ni precursor ratio from 2:1 to 1:4, exhibiting a shape transformation from dumbbell-like to quasi-spherical owing to the Ni NP size expansion, whereas the Au NP maintained their size.

Formulation Optimization and in Vitro Characterization of Orally Disintegrating Films Using a Factorial Design and Mathematical Modeling for Drug Release.

Even though experimental designs are becoming popular especially for conventional dosage forms, limited studies have been performed to optimize formulations of orally disintegrating films (ODFs). This study aimed to evaluate sildenafil citrate-loaded ODFs for a controlled release with hydroxypropyl methylcellulose as a film-forming polymer. A factorial design was utilized for optimization with three control factors: ethanol ratio, plasticizer ratio, and the type of plasticizer.