Recent Advances of Nitrobenzoselenadiazole for Imaging and Therapy.

The development and practical applications of multifunctional organic fluorophores have garnered significant attention in translational research in recent years. Among the fluorophores, nitrobenzodioxazole (NBD) has been widely used in various fields due to its small size and neutral character, both of which are advantageous for biorelated applications. However, NBD presents some limitations, including (1) suboptimal photophysical properties for in vivo applications and (2) its monofunctional nature, which restricts its use in fluorescence-based bioimaging and sensing.

Dimethysiloxane polymer for the effective transdermal delivery of donepezil in Alzheimer's disease treatment.

Donepezil (DNZ) has been used to treat dementia associated with mild, moderate, or severe Alzheimer's disease (AD). DNZ uptake can alleviate cognitive symptoms in AD patients acetylcholinesterase (AChE) inhibition. However, oral administration of DNZ has limitations, including first-pass metabolism, difficulties with swallowing, and low patient compliance.