Effect of Acupuncture on Simple Obesity and Serum Levels of Prostaglandin E and Leptin in Sprague-Dawley Rats.

Aim: The study is aimed at investigating the curative effect of acupuncture on simple obesity and its influence on serum levels of prostaglandin E and leptin in Sprague-Dawley (SD) rats.

Methods: In the study, there are 50 male SD rats. We took 10 as healthy controls and fed 40 with a diet of high fat for 8 weeks.

[Electroacupuncture improves lung function by suppressing mucin-5AC mediated EGFR-p38MAPK signaling and inflammation reaction in chronic obstructive pulmonary disease rats].

Objective: To observe the effect of electroacupuncture (EA) at "Zusanli"(ST36) on the expression of epidermal growth factor receptor (EGFR), tumor necrosis factor α(TNF-α) transfer growth factor α(TGF-α), interleukin-8(IL-8), p38 mitogen-activated protein kinases (p38MAPK), mucin-5AC (MUC5AC) and other related factors in chronic obstructive pulmonary disease (COPD) rats, so as to reveal its underlying mechanisms in improving COPD.

Methods: A total of thirty male SD rats were randomly divided into normal control, model and EA groups, with 10 rats in each group. The COPD model was replicated using a combined method of tracheal infusion of lipopolysaccharide (LPS) and forced smoke-inhaling.

[Effect and its molecular mechanisms of curcumin on pulmonary artery smooth muscle cells in rat model with chronic obstructive pulmonary disease].

To investigate the effects and the underlying molecular mechanisms of curcumin on pulmonary artery smooth muscle cells in rat model with chronic obstructive pulmonary disease (COPD). A total of 75 male Wistar rats were randomly divided into control group (group CN), model group (group M), low-dose curcumin group (group CL), medium-dose curcumin group (group CM) and high-dose curcumin group (group CH). HE staining was used to observe the morphology of pulmonary artery.

[Effects of acupuncture on expression of norepinephrine transporter mRNA in the cervical sympathetic ganglion and beta1-AR mRNA in the heart in cerebral-cardiac syndrome rats].

Objective: To observe the effect of electroacupuncture (EA) intervention on the expression of norepinephrine transporter (NET) mRNA in the middle cervical-stellate ganglion complex (MC-SGC) and beta1-adrenergic receptor (beta1-AR) mRNA in the left ventricular myocardium in cerebral-cardiac syndrome (CCS) rats, so as to study its underlying mechanism in the prevention and treatment of CCS.

Methods: Eighteen Wistar rats were randomized into sham operation, model and EA groups (n=6). CCS model was duplicated by intravenous injection of 1 microL of saline containing collagenase (1 U/microL) + heparin (7 U/microL) into the caudate nucleus.

[Relatively specific effect of electroacupuncture of different acupoints on hypothalamic monoamine neurotransmitters in myocardial ischemia rats].

Objective: To observe the effect of electroacupuncture (EA) of "Shenmen" (HT 7), "Neiguan" (PC 6), etc. on monoamine neurotransmitter contents of hypothalamic paraventricular nucleus (PVN) region in myocardial ischemia (MI) rats, so as to analyze the substantial basis of efficacy specificity of acupoints in improving MI.

Methods: SD rats were randomized into normal control, model, EA-Shenmen (HT7), EA-Neiguan (PC 6) and EA-Taiyuan (LU 9) groups (n = 10/group).

[Effects of electroacupuncture of "Neiguan (PC 6) and Taichong (LR 3) on cardiac function in acute myocardial ischemia rabbits].

Objective: To observe the effect of electroacupuncture (EA) of "Neiguan" (PC 6) and "Taichong" (LR 3) on mechnical activities of the heart in acute myocardial ischemia (AMI) rabbits.

Methods: Fifty chinchilla rabbits were randomized into normal control, model, EA-PC 6, EA-LR 3 and non-acupoint groups (n = 8/group). AMI model was duplicated by intravenous injection (femoral vein) of posterior pituitrin (3 U/kg).

[Study on the mechanism of electroacupuncture of different acupoint groups in the treatment of cerebrocardiac syndrome in rats].

Objective: To compare the effects of electroacupuncture (EA) of different acupoint groups on heart rate variability (HRV) and cerebral glutamate (Glu) and aspartic acid (Asp) contents in cerebrocardiac syndrome (CCS) rats.

Methods: A total of 52 Wistar rats were randomized into normal (n = 8), sham-operation (sham, n = 8), model (n = 12), Shuigou-Fengfu (GV 26-GV 16, n = 12), and Neiguan-Xinshu (PC 6-BL 15, n = 12) groups. CCS model was established by intracerebral (Caudate nucleus) injection of clostridiopeptidase (1 U/microl) plus heparin (7 U/microl).

[Study on effects of acupuncture at the heart meridian on gene expression pattern of heart in rats with acute myocardial ischemia].

Objective: To reveal the mechanism of acupuncture at the Heart meridian in treatment of myocardial ischemia from gene level.

Methods: A model of acute myocardial ischemia was made by ligation of left anterior descending branch of the coronary artery. Changes of gene expression pattern of the Lung meridian group, the Heart meridian group and the model group in the heart were compared.