Publications by authors named "Yenny Y Rosli"
Background: Rectourethral fistula (RUF) is an uncommon serious condition with various etiologies including neoplasm, radiation therapy, and surgery. Treatment for RUF remains problematic with a high recurrence rate. Although studies have suggested the recurrence rate of RUF is lower after surgical repair using a gracilis flap, outcomes have varied and the studies were small and inadequately controlled.
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- Anti-TNF antibodies are commonly used to treat inflammatory bowel disease (IBD), but some patients do not respond, indicating the presence of TNF-independent forms of the disease.
- Research showed that deleting specific IBD susceptibility genes (A20 and Abin-1) in intestinal epithelial cells led to increased death from both TNF-dependent and TNF-independent mechanisms.
- Additionally, the study found that blocking the action of lymphotoxin α (LTα) could mitigate weight loss and improve survival, revealing the complex role of microbial signals and specific pathways in TNF-independent intestinal injury.
A20 () and ABIN-1 () are candidate susceptibility genes for inflammatory bowel disease and other autoimmune or inflammatory diseases, but it is unclear how these proteins interact in vivo to prevent disease. Here we show that intestinal epithelial cell (IEC)-specific deletion of either A20 or ABIN-1 alone leads to negligible IEC loss, whereas simultaneous deletion of both A20 and ABIN-1 leads to rapid IEC death and mouse lethality. Deletion of both A20 and ABIN-1 from enteroids causes spontaneous cell death in the absence of microbes or hematopoietic cells.
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